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JCI online early table of contents: July 18, 2011
Date:7/18/2011

ntified a mechanism by which some tumor cellkilling chemotherapeutic drugs currently in use (specifically, platinum-based drugs such as cisplatin) oppose the immune inhibitory mechanisms employed by tumors and thereby promote anticancer immune responses. The authors therefore suggest that their data provide rationale for the use of platinum-based anticancer chemotherapeutic drugs together with immune-modulating approaches to increase the effectiveness of cancer treatment.

TITLE: Platinum-based drugs disrupt STAT6-mediated suppression of immune responses against cancer in humans and mice

AUTHOR CONTACT:
I. Jolanda M. de Vries
Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands.
Phone: 31.24.361.76.00; Fax: 31.24.354.03.39; E-mail: j.devries@ncmls.ru.nl.

W. Joost Lesterhuis
Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands.
Phone: 31.24.361.03.53; Fax: 31.24.354.07.88; E-mail: w.lesterhuis@onco.umcn.nl.

View this article at: http://www.jci.org/articles/view/43656?key=8c437fc525a30a1a3eab


BONE BIOLOGY: The protein 3BP2 performs a balancing act in bone

Cherubism is a genetic disorder characterized by facial abnormalities that result from excessive bone destruction by activated bone cells known as osteoclasts. It is caused by mutations in the SH3BP2 gene that result in gain-of-function effects on the protein templated by the gene, the protein 3BP2. A team of researchers, led by Robert Rottapel, at the University of Toronto, Toronto, has now defined in mice the function of normal 3BP2 in bones, something about which little was previously known.

Rottapel and colleagues found that mice lacking 3BP2 developed osteoporosis as a result of reduced bone formation by bone cells
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Contact: Karen Honey
press_releases@the-jci.org
734-546-5242
Journal of Clinical Investigation
Source:Eurekalert

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