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JCI online early table of contents: July 12, 2010
Date:7/12/2010

="http://www.jci.org/articles/view/42542?key=a5fdc1635d3e3176976e">http://www.jci.org/articles/view/42542?key=a5fdc1635d3e3176976e


BONE BIOLOGY: Generation of bone-destroying cells promoted by the protein ATF4

Maintaining healthy bone density requires that the number of bone-forming cells (osteoblasts) is balanced by the number of bone-destroying cells (osteoclasts). Increased numbers and/or function of osteoclasts is a feature of diseases such as osteoporosis, Paget disease of bone, and rheumatoid arthritis. A team of researchers, led by Guozhi Xiao, at the University of Pittsburgh, Pittsburgh, has now generated several lines of evidence that indicate that the gene regulatory protein ATF4 has an important role in promoting the generation of osteoclasts in mice. For example, the generation of osteoclasts in ATF4-deficient bones was dramatically reduced when compared with the generation of such cells in normal bones. The authors therefore suggest that targeting ATF4 might provide a way to treat diseases associated with increased osteoclast numbers and/or activity.

TITLE: Activating transcription factor 4 regulates osteoclast differentiation in mice

AUTHOR CONTACT:
Guozhi Xiao
University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Phone: 412.360.3036; Fax: 412.360.6960; E-mail: xiaog@upmc.edu.

View this article at: http://www.jci.org/articles/view/42106?key=cf4fdabb80ca8ff2f5b4


HEPATOLOGY: Integrating death-inducing and survival signals in liver disease

Acute (fulminant) hepatitis is a major cause of drug-induced liver failure. The protein Fas plays a role in the establishment of fulminant hepatitis because its activation elicits signals to surrounding cells that induce their death and others that protect them. The mechanisms by
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