Navigation Links
JCI online early table of contents: July 12, 2010
Date:7/12/2010

A>.

View this article at: http://www.jci.org/articles/view/42219?key=c08e601b8830b324c1e4

ONCOLOGY: Pathways to cancer: follow the protein Gankyrin

Mutations that activate Ras proteins drive cancer onset and progression and are found in approximately 30% of human cancers. Despite their key role in human disease, the tumorigenic pathways downstream of activated Ras have yet to be completely defined. Data generated by Xue-Min Zhang, Hui-Yan Li, and colleagues, at the National Center of Biomedical Analysis, China, has identified a new molecular pathway with an essential role in Ras-initiated tumorigenesis in mouse and human cells.

Specifically, Zhang, Li, and colleagues found that the protein Gankyrin increases interaction between two proteins known as RhoA and RhoGDI; this decreases RhoA activity, which leads to inhibition of the protein ROCK; this in turn prolongs activation of the protein Akt, an event known to be critical in activated Rasinduced tumor onset and progression. As the authors find that Gankyrin is a critical mediator of Ras-induced tumorigenesis, they suggest it could be a therapeutic target for the treatment of cancers caused by activating Ras mutations.

TITLE: Gankyrin plays an essential role in Ras-induced tumorigenesis through regulation of the RhoA/ROCK pathway in mammalian cells

AUTHOR CONTACT:
Xue-Min Zhang
Institute of Basic Medical Sciences, National Center of Biomedical Analysis, Beijing, China.
Phone: 86.10.86538178; Fax: 8610.68246161; E-mail: xmzhang@nic.bmi.ac.cn.

Hui-Yan Li
Institute of Basic Medical Sciences, National Center of Biomedical Analysis, Beijing, China.
Phone: 86.10.86538473; Fax: 8610.68246161; E-mail: lhy@proteomics.cn.

View this article at: '/>"/>

Contact: Karen Honey
press_releases@the-jci.org
734-546-5242
Journal of Clinical Investigation
Source:Eurekalert

0

GOOD

Page: 1 2 3 4 5 6 7 8

Related medicine news :

1. Online coverage of XVIII International AIDS Conference to include daily webcasts, live coverage, podcasts and news recaps
2. Sam's Club Tests Online Small Business Loan Program for Main Street
3. SNM cautions that Canadas Chalk River coming back online will not solve long-term isotope shortage
4. Suite 101.com Provides Insight Into Consumer Reading Behavior Online
5. Grand Opening of GreenProductsandGifts.com Online Store Offering Eco Friendly Gifts that are Proudly Made in the USA
6. Vibration Exercise Equipment Available at Fitness4HomeOnline.com
7. Onlineshoes.com and New Balance Pair Up for Toning Shoes Giveaway
8. Online Deals on Golf, now in Full Swing at GolfAdventures.com
9. BVibrantNow, A New All-Natural Health Supplement Business, Launches Free Online Wellness Calendar to Promote Healthy Habits
10. Publishing and Media Distribution Firm Launches Online Public Relations Kit for Businesses Seeking Free Publicity
11. JCI online early table of contents: July 1, 2010
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/24/2013)... Range Kleen Mfg. strives to “TCOTC.” Our number one ... President's desk to the Shipping Dock.” We hold high in ... passion while creating excellence and quality being results oriented. It ... the right thing and what better way to help with ... , Throughout the year Range Kleen donates to numerous local ...
(Date:5/24/2013)... HealthDay Reporter , , FRIDAY, May 24 (HealthDay News) -- ... But it was a physical challenge in her childhood ... sport. "I was an 11-year-old girl with my ... diagnosed by my orthopedic surgeon," said Lewis, who has ... and the American Academy of Orthopaedic Surgeons so she ...
(Date:5/24/2013)... 24, 2013 With Memorial Day Weekend upon ... Insurance is offering tips to help prevent grill fires ... Protection Association (NFPA) reports that gas grills led to ... Charcoal or other solid-fueled grills, meanwhile, caused approximately 1,200 home ... result, Amica Insurance is sharing the following tips from the ...
(Date:5/24/2013)... Portland, OR (PRWEB) May 24, 2013 ... and Sustainable Cards, major competitors in sustainable card ... awareness of using forest materials as a sustainable ... committee is to identify industry challenges and increase ... gift card programs to support the reduction of ...
(Date:5/24/2013)... 2013 Area homeowners dreaming about owning a ... tubs to choose from at factory-direct pricing during the ... event takes place at Emerald Pool and Patio ... Jacuzzi, the industry's leading hot tub brand, scheduled the event ... The event will feature popular hot tub models at up ...
Breaking Medicine News(10 mins):Health News:Range Kleen Partners with Berndes in Red Cross Promotion: Taking Care of Oklahoma 2Health News:Top-Ranked Golfer Beats Scoliosis 2Health News:Top-Ranked Golfer Beats Scoliosis 3Health News:Don’t Get Burned: Five Grilling Tips from Amica Insurance 2Health News:Making Gift Cards Greener- Competitors Combine Efforts to Educate and Empower Merchants 2Health News:Making Gift Cards Greener- Competitors Combine Efforts to Educate and Empower Merchants 3Health News:Truckload of Jacuzzi® Hot Tubs Rolls into Bend, Oregon on May 24, 2013 for Sales Event 2
... the continued presence of a doula an experienced non-medical ... beneficial effects for middle- and upper-class women in childbirth, even ... with them, according to a new study in the journal ... of 420 pregnant women in their third trimester were randomized ...
... CHESTNUT HILL, MA A critical enzyme used to ... help drug makers better target the cells the natural ... 23 edition of the Journal of Biological Chemistry. , ... of researchers from Boston College and the University of ...
... WILMINGTON, Del., May 29 AARP announced today ... reveals concerns,regarding health care access and affordability. AARP presented ... needs and disparities in,Delaware. View Delaware Health Care: A ... ., The key survey findings show that controlling ...
... 29 PartnerRe Ltd.,(NYSE: PRE ) today announced ... is scheduled to present at the Fox,Pitt-Kelton Cochran Caronia ... for the Insurers... and the Contrast with,Banks." The half-day ... 2008 from 9 a.m. - 2 p.m. local time ...
... N.C., May 29 Quality projects are not ... not,breakthroughs. However, these increments can grow to be ... had median savings of $1.2,million from their largest-impact ... complimentary excerpt "Transforming the Supply Chain: The,Impact of ...
... 60 Different Medical and Aesthetic ... ... Ltd. ("Alma Lasers"), a,global developer and marketer of laser, light, and ... clearance,for its Harmony(XL), the newest platform for multiple aesthetic laser and,light ...
Cached Medicine News:Health News:Enzyme may hold key to improved targeting of cancer-fighting drugs 2Health News:AARP Survey Reveals Boomers' Health Care Needs in Delaware 2Health News:AARP Survey Reveals Boomers' Health Care Needs in Delaware 3Health News:PartnerRe Executive Vice President & Chief Financial Officer Albert Benchimol to Present at the FPK CCW Credit Risk Conference in London on June 6, 2008 2Health News:Alma Lasers Announces FDA Clearance of the Harmony(XL) Multi-Application System at THE Aesthetic Show 2008 2
(Date:5/24/2013)... , May 24, 2013  Sinovac Biotech Ltd. ... of biopharmaceutical products in China ... subsidiary company of Sinovac, obtained the Certificate of ... from the China State and Food Administration (CFDA) ... production plants, and its Changping filing and packaging ...
(Date:5/23/2013)... CHINA , May 24, 2013 ... or the "Company"), a leading China ... manufacturing and marketing biopharmaceutical products, announced today that, ... "EGM"), the Company,s shareholders voted in favor of ... announced agreement and plan of merger dated February ...
(Date:5/23/2013)... -- Neurocrine Biosciences, Inc. (Nasdaq: NBIX ) announced ... Chief Executive Officer of Neurocrine Biosciences, will be presenting at ... Conference in Boston.   The live presentation takes ... / 8:20 a.m. Pacific Time.  The presentation will be webcast ... http://www.neurocrine.com . If you are unable to ...
Breaking Medicine Technology:Sinovac Beijing Obtains China GMP Certificate Under the New GMP Guidelines 2Sinovac Beijing Obtains China GMP Certificate Under the New GMP Guidelines 33SBio Inc. Announces Shareholders' Approval of the Amended Merger Agreement 23SBio Inc. Announces Shareholders' Approval of the Amended Merger Agreement 3
... N.Y., Feb. 21, 2012  Regeneron Pharmaceuticals, Inc. (Nasdaq: ... following investor conferences: , Citi 2012 Global Healthcare ... 28, 2012 , RBC Capital Markets, Healthcare Conference ... 2012 The sessions may be accessed through ...
... PHILADELPHIA, Pennsylvania and WALTHAM, Massachusetts, February 21, 2012 ... clinical decision support content and analytics tools into ... Elsevier , a world-leading provider of scientific, ... PatientKeeper ®, the leading provider of physician ...
Cached Medicine Technology:Regeneron Announces February 2012 Investor Conference Presentations 2Elsevier Integrates its Clinical Decision Support Solutions Into PatientKeeper CPOE 2Elsevier Integrates its Clinical Decision Support Solutions Into PatientKeeper CPOE 3Elsevier Integrates its Clinical Decision Support Solutions Into PatientKeeper CPOE 4
... Diagnostics Histoplasma DxSelect is intended for qualitatively ... in human serum. The test is indicated ... disease, as an aid in the presumptive ... is not intended for self-testing, and this ...
... Indirect immunofluorescent antibody (IFA) ... and semi-quantitation of human ... Epstein-Barr viral capsid antigen ... ten 12-well slides, FITC ...
... portable, battery-powered, micro-controlled, noninvasive bone growth stimulator ... primary lumbar spinal fusion surgery for one ... been shown in pre-clinical studies to help ... Clinical studies have also shown that individuals ...
... Medical Solutions introduces its new multifunctional ... with intuitive patient data management is ... and urological table. Lithoskop is an ... that covers all applications like lithotripsy, ...
Medicine Products: