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JCI online early table of contents: July 12, 2010
Date:7/12/2010

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View this article at: http://www.jci.org/articles/view/42219?key=c08e601b8830b324c1e4


ONCOLOGY: Pathways to cancer: follow the protein Gankyrin

Mutations that activate Ras proteins drive cancer onset and progression and are found in approximately 30% of human cancers. Despite their key role in human disease, the tumorigenic pathways downstream of activated Ras have yet to be completely defined. Data generated by Xue-Min Zhang, Hui-Yan Li, and colleagues, at the National Center of Biomedical Analysis, China, has identified a new molecular pathway with an essential role in Ras-initiated tumorigenesis in mouse and human cells.

Specifically, Zhang, Li, and colleagues found that the protein Gankyrin increases interaction between two proteins known as RhoA and RhoGDI; this decreases RhoA activity, which leads to inhibition of the protein ROCK; this in turn prolongs activation of the protein Akt, an event known to be critical in activated Rasinduced tumor onset and progression. As the authors find that Gankyrin is a critical mediator of Ras-induced tumorigenesis, they suggest it could be a therapeutic target for the treatment of cancers caused by activating Ras mutations.

TITLE: Gankyrin plays an essential role in Ras-induced tumorigenesis through regulation of the RhoA/ROCK pathway in mammalian cells

AUTHOR CONTACT:
Xue-Min Zhang
Institute of Basic Medical Sciences, National Center of Biomedical Analysis, Beijing, China.
Phone: 86.10.86538178; Fax: 8610.68246161; E-mail: xmzhang@nic.bmi.ac.cn.

Hui-Yan Li
Institute of Basic Medical Sciences, National Center of Biomedical Analysis, Beijing, China.
Phone: 86.10.86538473; Fax: 8610.68246161; E-mail: lhy@proteomics.cn.

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Contact: Karen Honey
press_releases@the-jci.org
734-546-5242
Journal of Clinical Investigation
Source:Eurekalert

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