Navigation Links
JCI online early table of contents: July 12, 2010
Date:7/12/2010

e in CpG elicit vigorous CD4+ T cell responses against blood-stage malaria in mice

AUTHOR CONTACT:
Michael F. Good
Queensland Institute of Medical Research, Brisbane, Queensland, Australia.
Phone: 61.7.3362.0203; Fax: 61.7.3362.0110; E-mail: Michael.Good@qimr.edu.au.

View this article at: http://www.jci.org/articles/view/39222?key=c05c1cb488663ceb3c72


NEUROBIOLOGY: Protein mislocalization gets nerve cells all excited

Individuals with the childhood epilepsy syndrome genetic epilepsy with febrile seizures plus (GEFS+) suffer generalized epilepsies of variable severity and febrile seizures, which are convulsions brought on by a fever. GEFS+ is often associated with genetic mutations that alter the function of proteins known as sodium channels. To investigate how such mutations cause the symptoms of GEFS+, a team of researchers, led by Steven Petrou, at The University of Melbourne, Australia, generated mice expressing one copy of a mutated gene associated with GEFS+ in humans. This gene made a C121W mutant version of the beta-1 sodium channel accessory subunit protein. Detailed analysis of the mice led the team to conclude that the beta-1 sodium channel accessory subunit protein normally modulates the excitability of regions of pyramidal nerve cells known as the axon initial segments and that the C121W mutant protein was excluded from such regions, thereby disrupting the regulation of axon initial segment excitability and causing epilepsy.

TITLE: Axon initial segment dysfunction in a mouse model of genetic epilepsy with febrile seizures plus

AUTHOR CONTACT:
Steven Petrou
The University of Melbourne, Parkville, Victoria, Australia.
Phone: 61.3.83441957; Fax: 61.3.93470446; E-mail: spetrou@unimelb.edu.au'/>"/>

Contact: Karen Honey
press_releases@the-jci.org
734-546-5242
Journal of Clinical Investigation
Source:Eurekalert

Page: 1 2 3 4 5 6 7 8

Related medicine news :

1. Online coverage of XVIII International AIDS Conference to include daily webcasts, live coverage, podcasts and news recaps
2. Sam's Club Tests Online Small Business Loan Program for Main Street
3. SNM cautions that Canadas Chalk River coming back online will not solve long-term isotope shortage
4. Suite 101.com Provides Insight Into Consumer Reading Behavior Online
5. Grand Opening of GreenProductsandGifts.com Online Store Offering Eco Friendly Gifts that are Proudly Made in the USA
6. Vibration Exercise Equipment Available at Fitness4HomeOnline.com
7. Onlineshoes.com and New Balance Pair Up for Toning Shoes Giveaway
8. Online Deals on Golf, now in Full Swing at GolfAdventures.com
9. BVibrantNow, A New All-Natural Health Supplement Business, Launches Free Online Wellness Calendar to Promote Healthy Habits
10. Publishing and Media Distribution Firm Launches Online Public Relations Kit for Businesses Seeking Free Publicity
11. JCI online early table of contents: July 1, 2010
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/4/2015)... ... September 04, 2015 , ... IVF New England, one of ... Hampshire fertility "ManchVegas Happy Hour" in Manchester for women who wish to learn more ... XO on Elm restaurant and lounge, 827 Elm Street, Manchester, NH from 6PM to ...
(Date:9/4/2015)... ... September 04, 2015 , ... A ... Compassion Project. Core Compassion Project is a non-profit organization dedicated to offering ... side effects of cancer treatments and recover their mobility, strength, and range of ...
(Date:9/4/2015)... HI (PRWEB) , ... September 04, 2015 , ... “Getting ... best ways for couples to explore, revitalize and strengthen their ‘couple-ness,’” says Jean ... his team at Four Seasons Resort Maui, the island’s only Forbes Five Star resort ...
(Date:9/4/2015)... ... ... The USC Eye Institute is proud to announce that the USC ... and staff are honored to have contributed to the success of our program. , ... Our faculty places a high priority on our educational programs in training the next ...
(Date:9/4/2015)... ... September 04, 2015 , ... Lalonde Gordon ran a ... followed up with victory in the men’s 400 meters final, with an impressive 44.89 ... Field Championships in San Jose, Costa Rica in August 2015. The 44.64 time is ...
Breaking Medicine News(10 mins):Health News:IVF New England to Host ManchVegas New Hampshire Fertility Happy Hour on October 15, 2015 in Manchester for Women Who Wish to Learn More About Fertility and Egg Freezing 2Health News:Girl’s Night Out to Benefit Core Compassion Project, Located at the Beautiful, Morning Glory Farm 2Health News:Couples Season at Four Seasons Resort Maui Begins This Week With Best Hotel Rates of the Year through November 2Health News:Couples Season at Four Seasons Resort Maui Begins This Week With Best Hotel Rates of the Year through November 3Health News:USC Ophthalmology Residency Program Ranked in Top 10 by Doximity 2Health News:USC Ophthalmology Residency Program Ranked in Top 10 by Doximity 3Health News:Lalonde Gordon’s Recipe Brings Home the Gold 2Health News:Lalonde Gordon’s Recipe Brings Home the Gold 3
... 2011 Researchers conducting the ADVISE clinical ... stenosis severity, instantaneous wave-free ratio (iFR), yielded similar ... the use of adenosine to induce maximum hyperemia. ... annual Transcatheter Cardiovascular Therapeutics (TCT) scientific symposium, sponsored ...
... Nov. 11 (HealthDay News) -- Repeated bouts of pelvic ... and infertility, a new study says. Pelvic inflammatory disease ... marked by inflammation of the reproductive organs. The condition affects ... and one in 10 of them becomes infertile, according to ...
... NOVEMBER 11, 2011 A clinical trial ... in native coronary arteries found that treatment with ... old uncoated-balloon angioplasty (POBA). Results from the PEPCAD-DES ... annual Transcatheter Cardiovascular Therapeutics (TCT) scientific symposium, sponsored ...
... FRIDAY, Nov. 11 (HealthDay News) -- With their teachers, help, ... excel academically, according to a new study. Researchers from ... history of abuse, the most successful kids were those who ... first step, of course, is for teachers to watch for ...
... News) -- Certain types of anti-smoking ads may not be ... to a new study. University of Georgia researchers found ... warn how smoking can lead to disease and death and ... at health messages, there is usually a threat trying to ...
... Patients who are dependent on opioids (narcotic pain relievers) ... more difficulty recovering, a study recently published in the ... JBJS ) has found. These patients tend to have ... of complications, and are more likely to need additional ...
Cached Medicine News:Health News:Results of the ADVISE trial reported at TCT 2011 2Health News:STD Complication May Double Infertility Risk 2Health News:Results of the PEPCAD-DES trial reported at TCT 2011 2Health News:Teachers Critical in Helping Abused Kids Succeed 2Health News:Negative Anti-Smoking Ads Turn Off Anxious Viewers 2Health News:Take care with pain meds 2
(Date:9/4/2015)... India , September 4, 2015 ... Market by Application (Plasmapheresis, Plateletpheresis, Erythrocytapheresis, Leukapheresis, and Photopheresis) ... Technology and by Product - Global Forecast to 2020", ... to reach USD 2.5 Billion by 2020, growing at ... 2015 to 2020. Browse 139 Tables ...
(Date:9/4/2015)... Future Prospects for Companies in Antihistamines, Corticosteroids, ... - new study showing you trends, partnerships, and ... allergic rhinitis drugs heading? What are the commercial prospects ... you potential revenues and other trends to 2025, discussing ... report provides 273 tables, charts, and graphs. Discover the ...
(Date:9/4/2015)... Research and Markets ( http://www.researchandmarkets.com/research/gbd3bt/stability_testing ) ... of Pharmaceuticals (London, UK - December 2-3, 2015)" ... comprehensive two day seminar delegates will: - ... suitable for global arketing - Be able to ... and facilities - Know how to save resource ...
Breaking Medicine Technology:Apheresis Market Worth 2.5 Billion USD by 2020 2Apheresis Market Worth 2.5 Billion USD by 2020 3Apheresis Market Worth 2.5 Billion USD by 2020 4Apheresis Market Worth 2.5 Billion USD by 2020 5Allergic Rhinitis Drugs Market Forecast 2015-2025 2Allergic Rhinitis Drugs Market Forecast 2015-2025 3Allergic Rhinitis Drugs Market Forecast 2015-2025 4Allergic Rhinitis Drugs Market Forecast 2015-2025 5Allergic Rhinitis Drugs Market Forecast 2015-2025 6Allergic Rhinitis Drugs Market Forecast 2015-2025 7Stability Testing of Pharmaceuticals: 2 Day Seminar - London, UK - December 2-3, 2015 2
Protects skin from corrosive drainage with the standard wear, FlexWear skin barrier. Convenient: accommodates stomas up to 102 mm; wide bottom opening permits hand access; attached pouch closure....
Protects skin from corrosive drainage with the standard wear, FlexWear skin barrier. Extra Security with porous tape....
Built-in convexity means added security and skin protection for recessed, retracted and flush stomas...pre-cut openings. Security and confidence achieved by the internal No-Flowback Valves and soft d...
Protects the skin over extended wearing time from irritating discharge. Flextend skin barrier is the barrier of choice for urostomies and ileostomies with the added benefit of it being discreet in bo...
Medicine Products: