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JCI online early table of contents: July 12, 2010
Date:7/12/2010

result of its ability to promote production of the soluble immune factor TGF-beta in the brain. Importantly, a molecule that blocks AT1Rs reduced the severity of disease in the model of multiple sclerosis by reducing TGF-beta production. The authors therefore suggest that the AT1R-blocking drugs used to treat high blood pressure might be of benefit to individuals with multiple sclerosis.

TITLE: Angiotensin II sustains brain inflammation in mice via TGF-beta

AUTHOR CONTACT:
Lawrence Steinman
Stanford University School of Medicine, Stanford, California, USA.
Phone: 650.725.6401; Fax: 650.725.0627; E-mail: steinman@stanford.edu.

View this article at: http://www.jci.org/articles/view/41709?key=8f0637504b7a09b96526


VACCINE DESIGN: Targeting malaria-causing parasites in the blood

There is currently no vaccine against malaria. The vaccine that is in late-stage clinical trails is designed to target the malaria-causing parasites in the skin and liver, and it reduces the risk of disease by approximately 30-50%. A vaccine that targets the malaria-causing parasite while it is in the blood is likely to provide even more benefit, but such vaccines have been hard to design and develop. However, a team of researchers, led by Michael Good, at the Queensland Institute of Medical Research, Australia, has generated data in mice that suggest that it might now be possible to develop such vaccines. Specifically, they found that administering low doses of killed malaria-causing parasite together with molecules known as CpG-ODN triggered in mice an immune response that targeted malaria-causing parasites in the blood and provided durable and cross-strain protection against disease. The authors hope that their approach might be applicable in humans.

TITLE: Low doses of killed parasit
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Contact: Karen Honey
press_releases@the-jci.org
734-546-5242
Journal of Clinical Investigation
Source:Eurekalert

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