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JCI online early table of contents: July 12, 2010
Date:7/12/2010

nutritional status (such as insulin and IGF-1) have a role. A team of researchers, led by Sara DiVall, at Johns Hopkins University, Baltimore, has now confirmed that in mice IGF-1 does indeed have a key role in coordinating the timing of puberty onset.

To study the issue, the team generated mice lacking either the receptor for insulin or the receptor for IGF-1 in GnRH-producing nerve cells. Male and female mice in which the receptor for insulin had been deleted displayed normal timing of puberty and fertility, but male and female mice with the receptor for IGF-1 deleted showed delayed pubertal development but normal fertility. Furthermore, administration of IGF-1 to normal female mice triggered the onset of puberty. The authors therefore conclude that IGF-1 signaling is necessary for timely triggering of pulsatile GnRH production at puberty and that it helps coordinate puberty with a specific stage of body development.

TITLE: Divergent roles of growth factors in the GnRH regulation of puberty in mice

AUTHOR CONTACT:
Sara A. DiVall
Johns Hopkins University, Baltimore, Maryland, USA.
Phone: 410.502.7573; Fax: 410.502.7580; E-mail: sdivall1@jhmi.edu.

View this article at: http://www.jci.org/articles/view/41069?key=d77a16f9916e3782bd8d


IMMUNOLOGY: Drugs for high blood pressure of benefit in multiple sclerosis?

The hormone angiotensin II (Ang II) is a key regulator of blood pressure. Drugs that block the molecules to which Ang II binds to mediate its effects (AT1Rs) are used to treat high blood pressure. Now, a team of researchers, led by Lawrence Steinman, at Stanford University School of Medicine, Stanford, has identified Ang II as a molecule that sustains inflammation in the brain in mice with a disease that models multiple sclerosis. The effects of Ang II were a
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