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JCI online early table of contents: July 12, 2010
Date:7/12/2010

g/articles/view/42642?key=8810b92e3074e99478bd">http://www.jci.org/articles/view/42642?key=8810b92e3074e99478bd


EDITOR'S PICK: TIMely intervention for asthma

Asthma can be a severely debilitating disease. Its increasing prevalence and the fact that most treatments do not control severe asthma well has stimulated intensive research into genetic susceptibility to asthma in the hope that the information gleaned will lead to new therapeutics. One gene identified as a asthma susceptibility gene is TIM1 and now, a team of researchers, led by Paul Rennert, at Biogen Idec Inc., Cambridge, has generated data in a humanized mouse model of asthma that suggest that targeting TIM-1 protein might have therapeutic benefit in the treatment of patients with asthma. Specifically, the team found that an antibody that bound to a defined region of the TIM-1 protein (a cleft formed within the IgV domain) had therapeutic activity in the humanized mouse model of experimental asthma, ameliorating inflammation and airway hyperresponsiveness.

TITLE: Antagonism of TIM-1 blocks the development of disease in a humanized mouse model of allergic asthma

AUTHOR CONTACT:
Paul D. Rennert
Biogen Idec Inc., Cambridge, Massachusetts, USA.
Phone: 617.679.2986; Fax: 617.679.2304; E-mail: paul.rennert@biogenidec.com.

View this article at: http://www.jci.org/articles/view/39543?key=847e756d2bc7b2f37250


EDITOR'S PICK: The hormone IGF-1: a trigger of puberty

The onset of puberty is triggered by pulsatile release of the hormone GnRH from nerve cells in a region of the brain known as the hypothalamus. Exactly what signals tell these nerve cells to release GnRH in this manner has not been determined, although it has been suggested that hormones associated with good
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