Navigation Links
JCI online early table of contents: July 12, 2010
Date:7/12/2010

EDITOR'S PICK: Why Parkinson disease patients aren't walking talls

Many of the symptoms of Parkinson disease can be alleviated with drugs that target dompamine, a chemical in the brain that is involved in nerve cell communication and therefore known as a neurotransmitter. However, such drugs do not improve the gait disorders and falls that commonly affect individuals with severe and advanced forms of Parkinson disease. Understanding which nerve cells in the brain are involved in these symptoms of Parkinson disease might provide researchers with new therapeutic targets. In this context, a team of researchers, led by Chantal Franois and Etienne Hirsch, at Universit Pierre et Marie Curie Paris 6, France, has now determined that the presence of gait disorders in patients with Parkinson disease and in aged monkeys with Parkinson-like disease was associated with loss of nerve cells that produce the neurotransmitter acetylcholine in a region of the brain known as the pedunculopontine nucleus (PPN). Consistent with this, disrupting these nerve cells induced gait and postural deficits in monkeys. The authors therefore suggest that targeting acetylcholine-producing nerve cells in the PPN might provide a way to alleviate the gait disorders and falls experienced by individuals with Parkinson disease.

TITLE: Cholinergic mesencephalic neurons are involved in gait and postural disorders in Parkinson disease

AUTHOR CONTACT:
Chantal Franois
Universit Pierre et Marie Curie Paris 6, CR-ICM, UMR-S975, Paris, France.
Phone: 33.1.42.16.00.68; Fax: 33.1.45.82.88.93; E-mail: chantal.francois@upmc.fr.

Etienne C. Hirsch
Universit Pierre et Marie Curie Paris 6, CR-ICM, UMR-S975, Paris, France.
Phone: 33.1.42.16.22.02; Fax: 33.1.44.24.36.58; E-mail: Etienne.hirsch@upmc.fr.

View this article at:

Contact: Karen Honey
press_releases@the-jci.org
734-546-5242
Journal of Clinical Investigation
Source:Eurekalert

Page: 1 2 3 4 5 6 7 8

Related medicine news :

1. Online coverage of XVIII International AIDS Conference to include daily webcasts, live coverage, podcasts and news recaps
2. Sam's Club Tests Online Small Business Loan Program for Main Street
3. SNM cautions that Canadas Chalk River coming back online will not solve long-term isotope shortage
4. Suite 101.com Provides Insight Into Consumer Reading Behavior Online
5. Grand Opening of GreenProductsandGifts.com Online Store Offering Eco Friendly Gifts that are Proudly Made in the USA
6. Vibration Exercise Equipment Available at Fitness4HomeOnline.com
7. Onlineshoes.com and New Balance Pair Up for Toning Shoes Giveaway
8. Online Deals on Golf, now in Full Swing at GolfAdventures.com
9. BVibrantNow, A New All-Natural Health Supplement Business, Launches Free Online Wellness Calendar to Promote Healthy Habits
10. Publishing and Media Distribution Firm Launches Online Public Relations Kit for Businesses Seeking Free Publicity
11. JCI online early table of contents: July 1, 2010
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/25/2014)... 2014 Product liability lawsuits filed in ... ( http://www.consumerinjurylawyers.com/DePuy/ ) continue to move forward in federal ... issued in the U.S. District Court, Northern District of ... open conference on January 7, 2015, at the Paul ... West Palm Beach, Florida. The Conference is scheduled to ...
(Date:12/25/2014)... BellasDress has launched its Christmas Sale, offering ... chosen their best-selling lace wedding dresses, vintage bridesmaid dresses ... , Now, BellasDress.com features popular women’s dresses, and ... prices. The business hopes everyone can have a memorable ... “All our elegant products are made with exquisite materials; ...
(Date:12/25/2014)... Dennis Thompson HealthDay Reporter ... children with complex chronic illnesses can receive effective, less expensive ... with easy access to a team of dedicated health care ... to become seriously ill and need either hospitalization or a ... an enhanced medical home clinic at the University of Texas ...
(Date:12/25/2014)... AngelWeddingDress.com tries its best to translate the experience of ... has introduced its new collection of 2015 prom dresses, ... new prom outfits are guaranteed to contain the perfect ... specially designed for 2015. Anyone who wants to buy ... website before Jan. 26, 2015, the deadline of the ...
(Date:12/25/2014)... Each year trauma accounts for approximately ... admissions across the nation (according to the Centers ... National Hospital Ambulatory Medical Care Survey collected data ... 2010. They estimated that there were between 3.5 and ... primary diagnosis of broken bone or fracture. , ...
Breaking Medicine News(10 mins):Health News:Federal Court Overseeing DePuy ASR Hip Lawsuit Set to Convene Conference in January, Bernstein Liebhard LLP Reports 2Health News:Federal Court Overseeing DePuy ASR Hip Lawsuit Set to Convene Conference in January, Bernstein Liebhard LLP Reports 3Health News:BellasDress.com’s Christmas Sale: Trendy Wedding Dresses With Big Discounts 2Health News:Coordinated Care Through 'Medical Home' Best for Chronically Ill Kids: Study 2Health News:Coordinated Care Through 'Medical Home' Best for Chronically Ill Kids: Study 3Health News:Angelweddingdress 2015 Prom Dresses Online Now 2Health News:Every Year Four Million Emergency Department Visits Result from Accidents Involving Bone Trauma 2Health News:Every Year Four Million Emergency Department Visits Result from Accidents Involving Bone Trauma 3Health News:Every Year Four Million Emergency Department Visits Result from Accidents Involving Bone Trauma 4
... which suggests hormone suppression therapy could increase substantially ... free of the disease.Michel Bolla, a professor at ... suppressing the male hormone androgen, similar to the ... patients in advanced stages// of their prostate cancer, ...
... a good amount of fluids should be taken, in order ... far better than 'energy' drinks for keeping you hydrated during ... you'll be well aware of the need to keep your ... lot of so-called energy drinks around, which seem to promise ...
... proteins, which are protective substances, produced by the body ... the TB bacteria, researchers in the UK report. According ... journal Nature Medicine,// these heat-shock proteins, which are special ... times and bolster the immune system of the body. ...
... According to new study, a new type of antidepressant, ... anxiety disorder (SAD) people experience fear, anxiety and dread ... which can make both work //and social situations a ... mental health problems, like depression, and the condition can ...
... at the University of Texas, have shown that use of ... to 70 per cent of US women born since 1950 ... that use of the hormones in the Pill could raise ... failed to reveal a connection. The early Pill users are ...
... at the University of Texas has found that caffeine ... in preterm infants. Sleep apnea is a condition characterized ... infants. However, there is a growing concern over caffeine's ... Texas analyzed the effects of caffeine on cardiac output, ...
Cached Medicine News:Health News:Hormone Therapy applicable for Prostate Cancer 2Health News:Caffeine reduces infant blood flow 2
(Date:12/24/2014)... N.C. , Dec. 23, 2014  Endo Pharmaceuticals ... ENDP ) (TSX: ENL), and BioDelivery Sciences International, ... they have submitted a New Drug Application (NDA) for ... Drug Administration (FDA).  Buprenorphine HCl Buccal Film is under ... require daily, around-the-clock, long-term opioid treatment and for which ...
(Date:12/22/2014)... , Dec. 22, 2014 Research and Markets ... of the "US Self-monitoring Blood Glucose Market" ... http://photos.prnewswire.com/prnh/20130307/600769 This market insight focuses on ... the United States . Reimbursement analysis ... Thorough product analyses for more than 73 SMBG meters ...
(Date:12/22/2014)... and STOCKHOLM , Dec. ... (Sobi) and partner Auxilium Pharmaceuticals, Inc. today announced that ... of the European Medicines Agency (EMA) has adopted a ... histolyticum) for the treatment of adult men with Peyronie,s ... at least 30 degrees at the start of therapy. ...
Breaking Medicine Technology:Endo Pharmaceuticals and BioDelivery Sciences Announce NDA Submission for Buprenorphine HCl Buccal Film for the Management of Moderate to Severe Chronic Pain 2Endo Pharmaceuticals and BioDelivery Sciences Announce NDA Submission for Buprenorphine HCl Buccal Film for the Management of Moderate to Severe Chronic Pain 3Endo Pharmaceuticals and BioDelivery Sciences Announce NDA Submission for Buprenorphine HCl Buccal Film for the Management of Moderate to Severe Chronic Pain 4Endo Pharmaceuticals and BioDelivery Sciences Announce NDA Submission for Buprenorphine HCl Buccal Film for the Management of Moderate to Severe Chronic Pain 5US Self-monitoring Blood Glucose Market 2Sobi's Xiapex receives positive opinion by CHMP for the treatment of Peyronie's disease 2Sobi's Xiapex receives positive opinion by CHMP for the treatment of Peyronie's disease 3Sobi's Xiapex receives positive opinion by CHMP for the treatment of Peyronie's disease 4Sobi's Xiapex receives positive opinion by CHMP for the treatment of Peyronie's disease 5Sobi's Xiapex receives positive opinion by CHMP for the treatment of Peyronie's disease 6
Straight shafts with 1 x 2 teeth and serrated handle with polished finish....
Straight shafts with 1 x 2 teeth and 6 mm tying platform. Wide smooth handle with polished finish....
Smooth 90 degree jaws with locking screw maintain proper stretch of sleeve for securing silicone bands....
Ergotec Vetriretinal Instrument System. Extra fine angled tips (3 mm). 20 ga. shaft tapering to 23 ga., 10 mm from tip. Overall length from rear rotation knob to tip....
Medicine Products: