JCI online early table of contents: Jul... (cle.php?id34957 ONCOLOGY: Pros...)

JCI online early table of contents: July 10, 2008

Date:7/10/2008

cle.php?id=34957

ONCOLOGY: Prostate cancer cells cause disease in bones with the help of FGF9

Although prostate cancer is the second most common cause of death from cancer in the US, it is not the tumor in the prostate that usually causes death. Rather, death mainly occurs as a result of the tumor spreading to the bones, where it is known as an osteoblastic bone metastasis. Treatments that deprive the tumor of male sex hormones (androgens) are usually effective, but only briefly as the tumors typically develop the ability to grow in the absence of androgens and the diseases progresses. New data, generated using two prostate cancer cell lines that lack expression of androgen receptors and that were derived from the bones of an individual with osteoblastic bone metastases, by Nora Navone and colleagues, at The University of Texas MD Anderson Cancer Center, Houston, have provided new insight into the mechanisms by which prostate cancer osteoblastic bone metastases progress.

The androgen receptornegative prostate cancer cell lines generated by the authors grew when transplanted into immunocompromised mice and generated osteoblastic bone metastases. A protein known as FGF9 was found to be expressed at higher levels in these cells lines than in other bone-derived prostate cancer cells and induced bone formation in an in vitro organ culture assay. Further, as blocking FGF9 reduced the osteoblastic bone metastases in mice transplanted with the cell lines and FGF9 was found to be expressed in all human prostate cancer osteoblastic bone metastases analyzed, the authors suggest that FGF9 has an important role in prostate cancer progression to osteoblastic bone metastases. The cells lines generated are also likely to be an important preclinical model for researchers developing therapeutics for osteoblastic bone metastases in individuals with prostate cancer.

TITLE: Androgen receptornegative human prostate cancer cell
'/>"/>

Contact: Karen Honey
press_releases@the-jci.org
215-573-1850
Journal of Clinical Investigation
Source:Eurekalert

0

GOOD

Page: 1 2 3 4 5 6 7 8
Related medicine news :

1. Online Advice Column Receives Critical Acclaim; Baby Boomers Found Resourceful During Crisis
2. New Faces on Facebook(R): ADHD Moms Online Community Offers Tools for Moms of Children with ADHD
3. Localized Online Marketing Campaign Serves to Raise Awareness of Prostate Cancer Treatment
4. TalktoaDoc.org Launch Allows Patients to Talk to Doctors Online Using a Webcam
5. TonerForAutism.com Strives to Fund Autism Research Through Online Sales
6. JCI online early table of contents: July 1, 2008
7. Guardian Makes the Cost of Dental Care More Transparent With New Online Tool
8. Medical Machines Online Announces the Overstock and Release of a New ECG Machine
9. FOX Networks Group in Partnership with Portico Learning Solutions Launches Online Employee Health and Safety Orientation Course for Over 3,300 Employees
10. Sacred Technology Delivers Divine Medicine Online
11. New online care for hypertension gets results

Post Your Comments:

(Date:3/18/2010)... Taxes, Other Tobacco Prevention Initiatives , ... , , ... ... ... WASHINGTON , March 18 Kids in New Jersey will take center stage in the fight against tobacco on March ...

(Date:3/18/2010)... ... , , ... ... ... New Hampshire will take center stage in the fight against tobacco on March 24 as they join thousands of young people nationwide ...

(Date:3/18/2010)... President and CEO, Legacy(SM) , ... , , ... ... WASHINGTON , March ... ...

(Date:3/18/2010)... of U.S. medical students choosing internal medicine residencies ... significantly impact the shortage of primary care physicians. ... Program report, 2,722 U.S. seniors at medical schools ... 3.4 percent increase from 2,632 in 2009. The ... (2,660), 2007 (2,680), and 2006 (2,668). In comparison, ...

(Date:3/18/2010)... In its 21-year history, under the ... leaders, SRLA has trained more than 40,000 teenagers from ... area to complete the 26.2 mile Los Angeles Marathon. ... volunteer leaders will again participate in the LA Marathon. ... SRLA,s mission is to challenge at-risk secondary students to ...

Breaking Medicine News(10 mins):Health News:New Jersey Kids 'Kick Butts' on March 24 2 Health News:New Jersey Kids 'Kick Butts' on March 24 3 Health News:New Jersey Kids 'Kick Butts' on March 24 4 Health News:New Jersey Kids 'Kick Butts' on March 24 5 Health News:New Hampshire Kids 'Kick Butts' on March 24 2 Health News:New Hampshire Kids 'Kick Butts' on March 24 3 Health News:New Hampshire Kids 'Kick Butts' on March 24 4 Health News:Food and Drug Administration Issues Final Rule Regarding Sale, Distribution, and Use of Cigarettes and Smokeless Tobacco 2 Health News:Food and Drug Administration Issues Final Rule Regarding Sale, Distribution, and Use of Cigarettes and Smokeless Tobacco 3 Health News:Food and Drug Administration Issues Final Rule Regarding Sale, Distribution, and Use of Cigarettes and Smokeless Tobacco 4 Health News:Food and Drug Administration Issues Final Rule Regarding Sale, Distribution, and Use of Cigarettes and Smokeless Tobacco 5 Health News:Residency match results not encouraging for adults needing primary care 2 Health News:Students Run LA Takes 40,000 Students Across the Marathon Finish Line Over Past 21 Years 2 Health News:Students Run LA Takes 40,000 Students Across the Marathon Finish Line Over Past 21 Years 3

[0] New Jersey Kids 'Kick Butts' on March 24 [0] New Hampshire Kids 'Kick Butts' on March 24 [0] Food and Drug Administration Issues Final Rule Regarding Sale, Distribution, and Use of Cigarettes and Smokeless Tobacco [0] Residency match results not encouraging for adults needing primary care [0] Students Run LA Takes 40,000 Students Across the Marathon Finish Line Over Past 21 Years

... Getty, a sport in the true sense of the word, ... bone marrow transplant from a baboon//, passed away in California ... companion for 26 years, his dad and three siblings. ... Getty following a cancer treatment. He became famous after Doctors ...

... by NHS hospitals because they are serving meals that are ... catering at 97 health trusts. ,The survey revealed ... food brought in by relatives and friends. Over 37% of ... or tasted disgusting. ,Over a fifth of patients claimed that ...

... in Atlanta have reiterated that knocking off a few ... onset of arthritis//. Doctors found nearly 31% of the ... adults against only 16% of arthritis sufferers from the ... for Disease Control have communicated the results conducted from ...

... minister of Australia, stirred up the hearts of many when ... time that she had battled cancer almost ten years ... Centre, she was addressing an august gathering of over 800 ... cancer report.,Over the ‘Pink Ribbon’ breakfast meeting at Sydney this ...

... death of an 11-year-old boy yesterday of H5N1 bird flu ... flu in Indonesia to 53 and cases of infection, 71. ... who was reported to have had contact with infected birds. ... last Thursday, and died Saturday evening. ,In Indonesia backyard ...

... the University of Montana has revealed that methamphetamine, when administered ... 80-90%. It was used initially to aggravate stroke symptoms and ... and was repeated in further attempts. ,The research was ... the brain responsible for learning functions. They were kept in ...

Other Medicine News:Health News:NHS Food Slowing Patient Recovery 2

Jeff Getty, AIDS Activist, Passes Away NHS Food Slowing Patient Recovery Physical Activity and Weight Management, Checks Onset of Arthritis Australian PM’s Brush with Cance Bird Flu Claims One More Victim in Indonesia Methamphetamine may Protect Neurons after Stroke Attack

(Date:3/18/2010)... March 18 Poniard Pharmaceuticals, Inc. ... innovative oncology therapies, today announced that the U.S. Patent ... the composition of matter patent for picoplatin as RE41209, ... 2010 . The reissue was applied for May ... , the USPTO released the "Issue Notification" for the ...

(Date:3/18/2010)... , March 18 ... Chief Executive Officer, Pfizer, was elected board ... of America (PhRMA) today at the trade ... Chief Executive Officer Christopher Viehbacher ... Directors, and John C. Lechleiter , ...

(Date:3/18/2010)... results in too much ammonia in the blood. , ... , , ... ... (Logo: ... ...

Breaking Medicine Technology:U.S. Patent and Trademark Office Grants Reissue Patent on Picoplatin Composition of Matter 2 U.S. Patent and Trademark Office Grants Reissue Patent on Picoplatin Composition of Matter 3 U.S. Patent and Trademark Office Grants Reissue Patent on Picoplatin Composition of Matter 4 U.S. Patent and Trademark Office Grants Reissue Patent on Picoplatin Composition of Matter 5 Pfizer's Jeffrey Kindler Becomes PhRMA Board Chairman; Christopher Viehbacher, John Lechleiter Assume New Posts 2 Pfizer's Jeffrey Kindler Becomes PhRMA Board Chairman; Christopher Viehbacher, John Lechleiter Assume New Posts 3 Pfizer's Jeffrey Kindler Becomes PhRMA Board Chairman; Christopher Viehbacher, John Lechleiter Assume New Posts 4 Pfizer's Jeffrey Kindler Becomes PhRMA Board Chairman; Christopher Viehbacher, John Lechleiter Assume New Posts 5 Pfizer's Jeffrey Kindler Becomes PhRMA Board Chairman; Christopher Viehbacher, John Lechleiter Assume New Posts 6 Pfizer's Jeffrey Kindler Becomes PhRMA Board Chairman; Christopher Viehbacher, John Lechleiter Assume New Posts 7 Pfizer's Jeffrey Kindler Becomes PhRMA Board Chairman; Christopher Viehbacher, John Lechleiter Assume New Posts 8 FDA Approves Drug to Treat Condition That Causes Elevated Ammonia Levels 2 FDA Approves Drug to Treat Condition That Causes Elevated Ammonia Levels 3 FDA Approves Drug to Treat Condition That Causes Elevated Ammonia Levels 4 FDA Approves Drug to Treat Condition That Causes Elevated Ammonia Levels 5 Johns Hopkins researchers track down protein responsible for chronic rhinosinusitis with polyps 61897 1 Johns Hopkins researchers track down protein responsible for chronic rhinosinusitis with polyps 61897 2 Johns Hopkins researchers track down protein responsible for chronic rhinosinusitis with polyps 61897 3 Exposure to lead tobacco smoke raises risk of ADHD 10856 1 Exposure to lead tobacco smoke raises risk of ADHD 10856 2 Measuring and modeling blood flow in malaria 61892 1 Measuring and modeling blood flow in malaria 61892 2

[0] U.S. Patent and Trademark Office Grants Reissue Patent on Picoplatin Composition of Matter [0] Pfizer's Jeffrey Kindler Becomes PhRMA Board Chairman; Christopher Viehbacher, John Lechleiter Assume New Posts [0] FDA Approves Drug to Treat Condition That Causes Elevated Ammonia Levels

... the Journal of the American Society of Hypertension demonstrate that ... ... hypertrophy, PARSIPPANY, N.J., June 16 A ... Hypertension demonstrates that,the hypertension treatment olmesartan medoxomil was effective in reversing,the ...

... Signed as Strategic Partner for the Phase ... 16 Transdel,Pharmaceuticals, Inc. (OTC Bulletin Board: ... administered,medications, today announced the initiation of its ... topical cream based non-steroidal,anti-inflammatory drug ("NSAID") for ...

New Study Shows BENICAR(R) (olmesartan medoxomil) Reverses Blood Vessel Damage Independent of Blood Pressure Lowering Transdel Initiates Ketotransdel(TM) Phase 3 Clinical Program for Pain

... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...

... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...

... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...

Medicine Products:

Disulfiram, Urine Disease Association HLA-C Typing Disease Association HLA-A Typing Direct Coombs (Anti-Human Globulin)

JCI online early table of contents: Jul...(cle.php?id34957 ONCOLOGY: Pros...),Health