Navigation Links
JCI online early table of contents: July 10, 2008
Date:7/10/2008

EDITOR'S PICK: Why men are more at risk of diseases caused by blood clots than women

Being male increases your risk of diseases caused by the inappropriate formation of a blood clot (a process known as thrombosis), such as heart attack and stroke, but the reasons for this are not completely understood. However, Ethan Weiss and colleagues at the University of California, San Francisco, have used a mouse model of thrombosis to shed new light on this matter.

Thrombosis-related proteins are made in the liver, where expression of the genes containing the information needed for their generation is regulated by growth hormone (GH), which is secreted in a sex-specific manner males secrete GH in a pulsatile fashion, whereas females secrete GH continuously. In this study, GH-deficient mice were protected from thrombosis in the model of disease. When female GH-deficient mice were given pulsatile GH (to mimic the manner in which GH is secreted in males) their ability to form blood clots resembled male mice. Conversely, when male GH-deficient mice were given continuous GH (to mimic the manner in which GH is secreted in females) their ability to form blood clots resembled female mice. The authors therefore conclude that sex-specific patterns of GH release mediate the gender-associated differences observed in susceptibility to diseases caused by inappropriate thrombosis, information that they hope will be of help in the development of sex-specific treatments for thrombosis.

TITLE: Sex differences in thrombosis in mice are mediated by sex-specific growth hormone secretion patterns

AUTHOR CONTACT:
Ethan J. Weiss
University of California, San Francisco, San Francisco, California, USA
Phone: (415) 514-0819; Fax: (415) 476-0424; E-mail: ethan.weiss@ucsf.edu.

View the PDF of this article at: https://www.the-jci.org/arti
'/>"/>

Contact: Karen Honey
press_releases@the-jci.org
215-573-1850
Journal of Clinical Investigation
Source:Eurekalert

Page: 1 2 3 4 5 6 7 8

Related medicine news :

1. Online Advice Column Receives Critical Acclaim; Baby Boomers Found Resourceful During Crisis
2. New Faces on Facebook(R): ADHD Moms Online Community Offers Tools for Moms of Children with ADHD
3. Localized Online Marketing Campaign Serves to Raise Awareness of Prostate Cancer Treatment
4. TalktoaDoc.org Launch Allows Patients to Talk to Doctors Online Using a Webcam
5. TonerForAutism.com Strives to Fund Autism Research Through Online Sales
6. JCI online early table of contents: July 1, 2008
7. Guardian Makes the Cost of Dental Care More Transparent With New Online Tool
8. Medical Machines Online Announces the Overstock and Release of a New ECG Machine
9. FOX Networks Group in Partnership with Portico Learning Solutions Launches Online Employee Health and Safety Orientation Course for Over 3,300 Employees
10. Sacred Technology Delivers Divine Medicine Online
11. New online care for hypertension gets results
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2015)... ... July 31, 2015 , ... Well-known for its unique ... wedding cakes with custom designs, making life just a little bit sweeter ... wedding cakes for each customer who orders one. , The bakery provides a full ...
(Date:7/31/2015)... ... July 31, 2015 , ... The 2015 New York ... family members, medical professionals, and researchers, covering a variety of topics related to ... collaborative effort between the Mesothelioma Applied Research Foundation and Memorial Sloan Kettering Cancer ...
(Date:7/31/2015)... ... 2015 , ... Girl Scouts of Historic Georgia and Peach State Health Plan ... "Be a Friend First" program. Representatives from Peach State Health Plan presented a $10,000 ... Plan and our parent company, Centene Corporation, are dedicated to raising anti-bullying awareness. We ...
(Date:7/31/2015)... , ... July 31, 2015 , ... BioViva USA, Inc. ... way we treat aging diseases. , BioViva announces it has begun a fundraiser ... with Alzheimer’s Disease (AD) and find a cure. MaxLife will grant 100% of the ...
(Date:7/31/2015)... Calgary, AB (PRWEB) , ... July 31, 2015 , ... ... changes. "When patients don't experience angina until a heart rate of 150 beats versus ... Fit Clinic in Calgary. "We are able to give life back to patients with ...
Breaking Medicine News(10 mins):Health News:Pastry Palace of Las Vegas Announces It Is Now Offering Custom Wedding Cakes in Las Vegas 2Health News:New York Area Mesothelioma Specialists to Present at Conference 2Health News:New York Area Mesothelioma Specialists to Present at Conference 3Health News:Peach State Health Plan Presents $10,000 Check for “Be a Friend First” Anti-Bullying Program to Local Girl Scouts 2Health News:BioViva USA, Inc.’s Alzheimer’s Disease Gene Therapy Human Trial 2Health News:BioViva USA, Inc.’s Alzheimer’s Disease Gene Therapy Human Trial 3Health News:Heart Fit Clinic Helps Patient Increase Fitness Level with External Counterpulsation 2
... for majority of patients, survey found , WEDNESDAY, Aug. ... associated with neck problems, according to the results of ... aged 25 to 78, who had two types of ... (spine fusion). , Before the surgery, 86.4 percent of ...
... , NEW YORK, Aug. 12 ... of Ogilvy Healthworld North America, have been appointed Joint Worldwide CEOs ... Young. , , In making the announcement, Mr. ... they are also very complementary individuals. Their joint mandate is ...
... ... business culture and long history of technology innovation to enhance research, development and innovation ... Scottsdale, AZ ... management and security, today announced the expansion of its global operations with the opening ...
... Aug. 12 With obesity now the greatest threat to the health ... than ever. According to a new study in the August 2009 ... American Dietetic Association , portion and calorie-controlled meal replacements used in ... , , The st u ...
... SWARTZ CREEK, Mich., Aug. 12 Diplomat Specialty Pharmacy announced today they ... Inc.,s annual ranking of the fastest-growing private companies in America. ... is an amazing achievement, the additional details are even more resounding," stated Phil ... , , , Of the 43 ...
... , , DANA POINT, Calif., Aug. ... have selected Artefill, the first and only FDA-approved microsphere-enhanced collagen filler ... looking for a longer lasting dermal filler. Drs. Kofford have been ... success and effectiveness for the correction of wrinkles. , ...
Cached Medicine News:Health News:Surgery for Neck Pain May Also Relieve Headaches 2Health News:Joint Worldwide CEO's of Ogilvy Healthworld Named 2Health News:Lumension Expands Global Footprint and Strengthens Capabilities with the Opening of a New Development Office in Ireland 2Health News:Lumension Expands Global Footprint and Strengthens Capabilities with the Opening of a New Development Office in Ireland 3Health News:New Published Diet Study Reveals Meal Replacements as Top Strategy for Weight Loss 2Health News:Diplomat Specialty Pharmacy Honored By Inc. Magazine As One Of The Nation's Fastest-Growing Companies 2Health News:Riviera Laser Studios Selects Artefill to Meet Growing Patient Demand for a Longer Lasting Dermal Filler 2Health News:Riviera Laser Studios Selects Artefill to Meet Growing Patient Demand for a Longer Lasting Dermal Filler 3
(Date:7/30/2015)... July 30, 2015  Amgen (NASDAQ: AMGN ... quarter of 2015. Key results include: , ... quarter of 2014 to $5,370 million, with 6 ... ® (etanercept), Prolia ® (denosumab), Sensipar ... XGEVA ® (denosumab). Unfavorable changes in foreign ...
(Date:7/30/2015)... China , July 30, 2015 Tianyin ... a pharmaceutical company that specializes in the patented biopharmaceutical, ... pharmaceutical ingredients (API), provided updates regarding the notice it ... LLC (the "Exchange") indicating that the Company was below ... forth in Sections 134 and 1101 of the NYSE ...
(Date:7/30/2015)...  Growth of the U.S. nonprescription market is primarily ... users to the OTC market. Due to an increasingly ... switch activity over the next five years with several ... brands entering the market into existing categories. ... (even those with low to moderate likelihood), the market ...
Breaking Medicine Technology:Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 2Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 3Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 4Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 5Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 6Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 7Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 8Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 9Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 10Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 11Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 12Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 13Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 14Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 15Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 16Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 17Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 18Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 19Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 20Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 21Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 22Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 23TPI Provides Update Regarding Non-Compliance with NYSE MKT Continued Listing Requirements 2Rx-to-OTC Switches -- Game Changers for the U.S. OTC Drugs Market through 2019, Sees Kline 2Rx-to-OTC Switches -- Game Changers for the U.S. OTC Drugs Market through 2019, Sees Kline 3
... Robert Mazzacavallo has joined Veridiam as the company,s Chief ... of high-precision, fabricated assemblies and metal components, primarily serving ... aerospace and general industrial markets. , Before joining Veridiam, ... Camas, WA. At C-Tech, Bob worked closely with ...
... 3 Corgenix Medical Corporation (OTC Bulletin Board: CONX), ... will host a conference call on Thursday, November 12, ... financial and operating performance for the first quarter ended ... product development and marketing activities. , Corgenix invites all ...
Cached Medicine Technology:Veridiam Names Robert Mazzacavallo New CFO 2
... 3200 sets a benchmark of innovative, ... for WBC, RBC, PLT and Reticulocyte ... needs of today's laboratory. The instrument ... analysis, automated sample handling, comprehensive data ...
... Data Management System provides comprehensive program management ... and the Precision PCx. The QC Manager ... collect, analyze, and report quality control data ... essential laboratory tool for managing data and ...
... The CELL-DYN SMS consistently produces high-quality ... ensuring consistent blood films every time, eliminating ... with significantly high or low hematocrit values. ... autoloader mixes, identifies the sample, and aspirates ...
... The QuickVue In-Line Strep A Test allows for ... directly from patient throat swab specimens. , ,QuickVue ... and is the first strep A test waived ... rapid procedure allow testing to take place at ...
Medicine Products: