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JCI online early table of contents: July 1, 2011
Date:7/1/2011

treat the condition. In this context, cells known as Tregs are of particular interest because they have a pivotal role in suppressing the proliferation and function of other immune cells. Verchere and colleagues used a virus to deliver the genetic information for making the protein CCL22 (a molecule known to attract Tregs) to insulin-producing cells in the pancreas of mice susceptible to a type 1 diabeteslike condition and found that it led to the recruitment of Tregs to the pancreas and long-term protection from diabetes. Importantly, virus-mediated expression of CCL22 in pancreatic cells transplanted into diabetic mice led to recruitment of Tregs to the grafts, prevention of insulin-producingcell destruction, and delayed diabetes recurrence. The team therefore suggests that delivering Treg attractants to the pancreas may provide a new way to treat type 1 diabetes.

TITLE: Prevention of murine autoimmune diabetes by CCL22-mediated Treg recruitment to the pancreatic islets

AUTHOR CONTACT:
C. Bruce Verchere
Child and Family Research Institute, Vancouver, British Columbia, Canada.
Phone: 604.875.2490; Fax: 604.875.2373; E-mail: bverchere@cfri.ca.

View this article at: http://www.jci.org/articles/view/43048?key=e02144b90bcf49ac8c33


ALLERGY AND ASTHMA: Stomach-colonizing bacterium protects against asthma

The number of people with asthma has increased sharply over the past few decades. This decrease has been linked to the disappearance of the bacterium Helicobacter pylori, which persistently colonizes the human stomach, from Western societies. A team of researchers led by Anne Mller, at the University of Zrich, Switzerland and Christian Taube, at Johannes Gutenberg University, Germany has now provided concrete evidence in mice to support this idea and identified an underlyin
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Contact: Karen Honey
press_releases@the-jci.org
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Journal of Clinical Investigation
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