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JCI online early table of contents: July 1, 2011
Date:7/1/2011

tively known as enteropathogens). Injectable vaccines fail to provide protection against enteropathogens because they do not trigger immune cells to travel to the gut. But now, a team of researchers, led by Reinhold Frster, at Hannover Medical School, has developed an approach to direct immune responses activated by a vaccine injected under the skin to the gut. Importantly, this approach (concurrent injection of a vaccine and the molecule retinoic acid [RA] under the skin) protected mice from cholera toxininduced diarrhea and decreased numbers of bacteria in their gut after oral infection with the bacterium Salmonella. The team therefore suggests that RA or its precursors, which include vitamin A, might be used to trigger immune cells activated by injectable vaccines to navigate to the gut in order to provide protection against enteropathogens.

TITLE: Retinoic acid induces homing of protective T and B cells to the gut after subcutaneous immunization in mice

AUTHOR CONTACT:
Reinhold Frster
Hannover Medical School, Hannover, Germany.
Phone: 49.511.5329733; Fax: 49.511.5329722; E-mail: Foerster.Reinhold@MH-Hannover.de.

View this article at: http://www.jci.org/articles/view/44262?key=26660a014dec788b9889


AUTOIMMUNITY: New recruits slow type 1 diabetes

A team of researchers, led by Bruce Verchere, at the Child and Family Research Institute, Vancouver, has now identified a way to harness a naturally occurring immunosuppressive mechanism to prevent the onset of disease in a mouse model of type 1 diabetes.

Type 1 diabetes occurs when a person's immune system attacks and destroys the cells in the pancreas that produce the hormone insulin. Some researchers are seeking to develop ways to harness the suppressive mechanisms of the patient's own immune system to
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Contact: Karen Honey
press_releases@the-jci.org
734-546-5242
Journal of Clinical Investigation
Source:Eurekalert

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