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JCI online early table of contents: July 1, 2011
Date:7/1/2011

ichigan Medical Center, Ann Arbor, provides insight into the cellular and molecular mechanisms that promote ovarian tumor development and thereby identifies a potential new therapeutic approach.

Mesenchymal stem cells (MSCs) are multipotent cells that have the capacity to generate many different cell types, including bone cells, cartilage cells, and fat cells. Strong evidence indicates that MSCs are recruited to tumors, but what they do when they get there is a matter of some controversy. Buckanovich and colleagues now show that carcinoma-associated MSCs (CA-MSCs) are present in the majority of human ovarian tumors and that they themselves are not cancerous, simply in the microenvironment of the tumor. Further analysis indicated that CA-MSCs promote tumor growth by increasing the number of cancer stem cells and that they do this, at least in part, through increased production of growth factors known as BMPs. The authors therefore conclude that MSCs in the ovarian tumor microenvironment contribute to tumor development and suggest that targeting BMPs might provide a new approach to treating ovarian cancer.

TITLE: Human ovarian carcinomaassociated mesenchymal stem cells regulate cancer stem cells and tumorigenesis via altered BMP production

AUTHOR CONTACT:
Ronald J. Buckanovich
University of Michigan Medical Center, Ann Arbor, Michigan, USA.
Phone: 734.764.2395; Fax: 734.936.7376; E-mail: ronaldbu@med.umich.edu.

View this article at: http://www.jci.org/articles/view/45273?key=6fd6a37b7c84ac931756


VACCINES: Vitamin A derivative redirects vaccine-activated immune cells to the gut

Diarrheal diseases are a major cause of childhood death in developing countries. They are caused by a wide array of bacteria, parasites, and viruses that infect the gut (these are collec
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Contact: Karen Honey
press_releases@the-jci.org
734-546-5242
Journal of Clinical Investigation
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