Navigation Links
JCI online early table of contents: July 1, 2010
Date:7/1/2010

EDITOR'S PICK: Identifying preterm infants at risk of life-threatening conditions

Infants born prematurely are highly susceptible to life-threatening conditions that are clinically difficult to detect. These include late-onset septicemia, a condition in which infectious microbes are present in the blood, and necrotizing enterocolitis, a condition in which portions of the intestines die. But now, Terrence Poon and colleagues, at the The Chinese University of Hong Kong, Hong Kong, have identified in the blood biomarkers of these devastating conditions. Importantly, the biomakers discovered in the initial analysis were validated in a prospective cohort study. Although the biomarkers need to be confirmed in further multicenter trials, the authors hope that their use will help diagnose preterm infants with these devastating conditions, thereby identifying those who require urgent treatment.

TITLE: Host-response biomarkers for diagnosis of late-onset septicemia and necrotizing enterocolitis in preterm infants

AUTHOR CONTACT:
Terence Chuen Wai Poon
Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong.
Phone: 852.2632.1205; Fax: 852.2648.8842; E-mail: tcwpoon@cuhk.edu.hk.

View this article at: http://www.jci.org/articles/view/40196?key=d4a5eb4e565373716d96


METABOLIC DISEASE: Childhood obesity: possible new insight from mice

Given the current 'epidemic' of obesity and its related diseases (including type 2 diabetes and heart disease), understanding how food intake, body composition, and energy expenditure are regulated has become a research priority. One soluble molecule found to regulate all these processes, and more, is leptin. Leptin causes many of its effects by acting on nerve cells in different regions of the brain, but exactly what effects each brain region mediates has not been clearly determined. However, Lori Zeltser and Laurence Ring have now generated mice in which leptin signaling is disrupted in only the hypothalamic region of the brain and shown that leptin signals in the hypothalamus are required to prevent the development of obesity up to 8 weeks of age. After 8 weeks of age, leptin signals in regions of the brain other than the hypothalamus were able to control further development of obesity, although they could not reverse obesity established prior to 8 weeks of age. The authors suggest that these data might have implications for combating childhood obesity.

TITLE: Disruption of hypothalamic leptin signaling in mice leads to early-onset obesity, but physiological adaptations in mature animals stabilize adiposity levels

AUTHOR CONTACT:
Lori M. Zeltser
Columbia University, New York, New York, USA.
Phone: 212.851.5314; Fax: 212.851.5306; E-mail: lz146@columbia.edu.

View this article at: http://www.jci.org/articles/view/41985?key=ee928b6505cbee5baee5


METABOLIC DISEASE: A tale of tribbles 3: understanding its role in type 2 diabetes

Type 2 diabetes is characterized by insufficient secretion of the hormone insulin, which controls glucose levels in the blood, and reduced mass of insulin-secreting pancreatic beta-cells. A team of researchers, led by Rohit Kulkarni, at Harvard Medical School, Boston, has now confirmed recent data indicating that a genetic variant of the tribbles 3 (TRB3) gene is associated with increased risk of developing type 2 diabetes and determined the reasons underlying this. Specifically, the protein generated by the genetic variant was shown to impair the release of insulin from mouse and human pancreatic beta-cells in which it was expressed and to reduce the mass of pancreatic beta-cells by decreasing their proliferation and enhancing their death. The authors therefore suggest that targeting TRB3 might help prevent two of the central characteristics of type 2 diabetes and thereby provide therapeutic benefit.

TITLE: The pseudokinase tribbles homolog 3 interacts with ATF4 to negatively regulate insulin exocytosis in human and mouse beta cells

AUTHOR CONTACT:
Rohit N. Kulkarni
Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, USA.
Phone: 617.713.3460; Fax: 617.713.3476; E-mail: Rohit.Kulkarni@joslin.harvard.edu.

View this article at: http://www.jci.org/articles/view/36849?key=53f83115ab8916a3b1e0


ONCOLOGY: Silencing genes that protect from cancer: a role for the protein hNaa10p

Tumor suppressor genes are genes that generate proteins that protect cells from becoming cancerous. Loss or reduction in their expression contributes to the onset of cancer. One mechanism by which tumor suppressor genes are silenced in cancer cells is excessive modification of their promoter (the region of the gene that drives expression) with molecules known as methyl groups. Understanding the mechanism underlying hypermethylation of tumor suppressor gene promoters might provide new approaches to cancer treatment.

In this regard, a team of researchers, led by Cheng-Wen Wu and Li-Jung Juan, at Academia Sinica, Taiwan, has now identified a role for the protein hNaa10p in mediating tumor suppressor gene silencing by promoting the function of the protein DNMT1, which transfers methyl groups to DNA. Importantly, depletion of hNaa10p impaired human lung cancer cell proliferation in vitro and upon transplantation into mice. Consistent with hNaa10p having a role in promoting lung tumor development, it was found to be overexpressed in many human lung tumor samples, and patients with the highest levels of hNaa10p expression had poor prognosis and survival. The authors therefore conclude that hNaa10P promotes tumor formation, although they caution that while this might be true for the lung, it might not be true in other tissues.

TITLE: hNaa10p contributes to tumorigenesis by facilitating DNMT1-mediated tumor suppressor gene silencing

AUTHOR CONTACT:
Cheng-Wen Wu
Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
Phone: 886.2.2652.3015; Fax: 886.2.2652.3075; E-mail: ken@ibms.sinica.edu.tw.

Li-Jung Juan
Genomics Research Center, Academia Sinica, Taipei, Taiwan.
Phone: 886.2.2787.1234; Fax: 866.2.2789.8811; E-mail: ljjuan@gate.sinica.edu.tw.

View this article at: http://www.jci.org/articles/view/42275?key=9cf8b56f73f4f7952258


ONCOLOGY: TGF-beta a DAB(2) hand at tumor promotion

The soluble factor TGF-beta has a complex role in tumor formation and progression. It seems to suppress tumor formation and early development but promote later tumor progression. A team of researchers, led by Gareth Inman, at The Beatson Institute for Cancer Research, United Kingdom, has now identified a mechanism by which TGF-beta switches from being a suppressor of tumor development to a promoter of tumor progression by studying human squamous cell carcinoma (the second most common type of skin cancer) cells in vitro and in vivo in mice. Specifically, they found that downregulation of the protein DAB2, which they determined occurs in human squamous cell carcinomas and predicted poor prognosis, abrogated the tumor suppressor function of TGF-beta. The authors suggest that determining whether or not DAB2 is downregulated might provide a way to stratify patients with advanced squamous cell carcinoma to identify those that might benefit from antiTGF-beta therapies.

TITLE: Epigenetic downregulation of human disabled homolog 2 switches TGF-beta from a tumor suppressor to a tumor promoter

AUTHOR CONTACT:
Gareth J. Inman
Biomedical Research Institute, University of Dundee, Dundee, United Kingdom.
Phone: +44.1382.496696; Fax: +44.1382.669993; E-mail: g.j.inman@dundee.ac.uk.

View this article at: http://www.jci.org/articles/view/36125?key=9ba8f92e6a5c850ecf45


CARDIOVASCULAR DISEASE: Zebrafish help us understand human blood vessel disease in the brain

Cerebral cavernous malformation is a common human disease of the small blood vessels in the brain that often results in stroke, seizure, and brain hemorrhage. It is caused by genetic mutations that result in loss of function of any one of three proteins (CCM1, CCM2, and CCM3). These proteins cooperate during blood vessel development in mice and zebrafish, but the downstream molecules involved in this process have not been determined. A team of researchers, led by Mark Kahn, at the University of Pennsylvania, Philadelphia, has now determined that proteins known as STKs act downstream of CCM3 in zebrafish development and a new zebrafish model of cerebral cavernous malformation caused by mutations in CCM3. These data suggest that the functional role of CCM3 in zebrafish parallels its role in humans and that future studies in zebrafish will provide a way to better understand the role of this protein in human cerebral cavernous malformation as well as possible way to test the efficacy of new drugs designed to treat the disease.

TITLE: CCM3 signaling through sterile 20like kinases plays an essential role during zebrafish cardiovascular development and cerebral cavernous malformations

AUTHOR CONTACT:
Mark L. Kahn
Department of Medicine and Cardiovascular Institute, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Phone: 215.898.9007; Fax: 215.573.2094; E-mail: markkahn@mail.med.upenn.edu.

View this article at: http://www.jci.org/articles/view/39679?key=953594aa09229ff769cd


MUSCLE BIOLOGY: Understanding how mutant proteins cause muscular dystrophy

Limb-girdle muscular dystrophy type 2A (LGMD2A) is a genetic disease characterized by progressive muscle weakness. Most patients become confined to a wheelchair in their third decade of life. Although LGMD2A is known to be caused by mutations in the gene CAPN3, which controls the generation of the protein p94, how mutant p94 proteins lead to disease has not been determined. Now, a team of researchers, led by Hiroyuki Sorimachi, at the Tokyo Metropolitan Institute of Medical Science, Japan, has determined that in mice, mutant p94 protein that is unable to cleave other proteins (a key function of p94) causes a disease that resembles LGMD2A and is exacerbated by exercise. The exercise-induced muscle degeneration was associated with inefficient relocalization of the mutant p94 protein. The authors therefore conclude that exercise-induced dynamic redistribution of p94 is dependent on its ability to cleave other proteins and essential to protect muscle from degeneration.

TITLE: Dynamic distribution of muscle-specific calpain in mice has a key role in physical-stress adaptation and is impaired in muscular dystrophy

AUTHOR CONTACT:
Hiroyuki Sorimachi
The Tokyo Metropolitan Institute of Medical Science (Rinshoken), Tokyo, Japan.
Phone: 81.3.5316.3277; Fax: 81.3.5316.3613; E-mail: sorimachi-hr@igakuken.or.jp.

View this article at: http://www.jci.org/articles/view/40658?key=a0e3462f9c84e525da8c


METABOLIC DISEASE: Disorder of fat absorption also affects the immune system

Abetalipoproteinemia is a rare genetic disorder caused by mutations in the gene responsible for generating the protein MTP. It is characterized by malabsorption of fats in the intestine and low levels of fat in the blood, as well as defects in liver, nerve cell, and eye function. Recently, MTP was shown to regulate the CD1 family of proteins that influence the immune system, but little is known about the function of the immune system in patients with abetalipoproteinemia. Now, a team of researchers, led by Richard Blumberg, at Brigham and Women's Hospital, Harvard Medical School, Boston, has determined that individuals with abetalipoproteinemia have immune defects. Specifically, defects in the numbers and function of immune cells known as iNKT cells, which become activated when they recognize microbial (and self) fat-containing molecules complexed with CD1 molecules. The authors therefore conclude that abetalipoproteinemia is not only a disorder that affects fat absorption, levels, and usage but also an immune disease involving CD1.

TITLE: Primary deficiency of microsomal triglyceride transfer protein in human abetalipoproteinemia is associated with loss of CD1 function

AUTHOR CONTACT:
Richard S. Blumberg
Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Phone: 617.732.6917; Fax: 617.264.5185; E-mail: rblumberg@partners.org.

View this article at: http://www.jci.org/articles/view/42703?key=42c843332541236b0321


'/>"/>

Contact: Karen Honey
press_releases@the-jci.org
734-546-5242
Journal of Clinical Investigation
Source:Eurekalert

Related medicine news :

1. Get All Your Questions About Women and Relationships Solved Online At WomanAdvice.com
2. ConnectedIn Divorce Resource Offers Online Expert Website for People Considering or Going Through Divorce
3. Highlighting a Bright Spot in a Down Economy, Career Step to Re-launch Online Healthcare Training Program
4. DrFinders Releases Searchable Online Directory of Doctors for All Medical Needs
5. AAP Offers New Online Pediatric Symptom Checker on HealthyChildren.org
6. Hospice Education Network (HEN) and the End-of-Life Nursing Education Consortium (ELNEC) announce online Geriatric Palliative Care Curriculum
7. Online Broker Lets Consumers Choose The Price of Life Insurance
8. X-ISS Launches Free Online Disaster Recovery Planning Assessment Tools for Small Businesses
9. Onlineshoes.com and Saucony Host Tweet-a-Thon for Kids' Health
10. Agilis Solutions Launches Ask Eileen! Online Q&A Column Answers Questions on Cloud, SaaS, Software Development and Outsourcing Issues and Trends
11. Natural Health Online Retailer VitaminsForLife.co.uk Expands Inventory to Meet UK Demands
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/11/2016)... Colorado (PRWEB) , ... February 11, 2016 , ... Colorado ... Review as one of 334 spine surgeons to know in 2016 . The ... in the field of spine surgery. , Dr. Corenman understands the importance of ...
(Date:2/11/2016)... ... February 11, 2016 , ... The annual list showcases the 20 Most Promising ... team dedication and commitment to the SharePoint ecosystem. A panel of experts and ... goal is to recognize and promote technology entrepreneurship. , The survey was made ...
(Date:2/11/2016)... ... February 11, 2016 , ... Husted Kicking ... San Diego, CA, on February 6th & 7th, 2016 according to kicking coach Michael ... were not invited to the NFL’s combine in Indianapolis,” says Husted. “The NFL uses ...
(Date:2/10/2016)... ... , ... President Obama’s budget proposal yesterday enables the HHS ... via telehealth, estimated to generate more than $160 million in savings over 10 ... Although there is more to be done, this represents an important victory ...
(Date:2/10/2016)... ... February 10, 2016 , ... ... , a full-service health care communications company offering education, research and medical ... for practitioners and specialists working in infectious diseases. , As the all-inclusive ...
Breaking Medicine News(10 mins):
(Date:2/11/2016)... NEW YORK , Feb. 11, 2016 /PRNewswire/ ... a foot-focused suite of products designed to support ... ExoSOLS™, are custom orthotic insoles that combine years ... 1,000 partners in the podiatric field with cutting ... align, and propel . It is supported by ...
(Date:2/10/2016)... DUBLIN , February 11, 2016 /PRNewswire/ ... the addition of the "Molecular Diagnostics ... --> http://www.researchandmarkets.com/research/rp4pg8/molecular ) has announced ... Reports Bundle" report to their offering. ... http://www.researchandmarkets.com/research/rp4pg8/molecular ) has announced the addition of ...
(Date:2/10/2016)... och PITTSBURGH , ... lämnas inte, och detta pressmeddelande får inte ... eller till, och inga anmälningssedlar kommer att ... i, något land där Erbjudandet, distribution av ... Erbjudandet skulle strida mot tillämpliga lagar eller ...
Breaking Medicine Technology: