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JCI online early table of contents: July 1, 2008
Date:7/1/2008

F6 (KLF6-SV1) as indicative of poor survival in men with prostate cancer.

The information in genes is converted into a protein via an intermediate known as mRNA. In the study, analysis of tumors from men with localized prostate cancer who had undergone a prostatectomy revealed that increased levels of an mRNA intermediate involved in the generation of KLF6-SV1 correlated with more rapid disease recurrence and decreased survival. Consistent with this having an important role in metastasis, prostate cancer cells expressing increased levels of KLF6-SV1 metastasized more rapidly and more often than normal prostate cancer cells in two mouse models of metastatic prostate cancer. Conversely, decreasing KLF6-SV1 expression in prostate cancer cells decreased tumor growth in mice. The authors therefore suggest that measuring KLF6-SV1 expression levels in prostate cancer tumors at the time of diagnosis might help clinicians predict whether or not the tumor will metastasize and that targeting KLF-SV1 might provide a new avenue for the development of therapeutics to treat individuals with prostate cancer.

TITLE: KLF6-SV1 overexpression accelerates human and mouse prostate cancer progression and metastasis

AUTHOR CONTACT:
John A. Martignetti
Mount Sinai School of Medicine, New York, New York, USA.
Phone: (212) 659-6744; Fax: (212) 849-2638; E-mail: john.martignetti@mssm.edu.

View the PDF of this article at: https://www.the-jci.org/article.php?id=34780


ENDOCRINOLOGY: Understanding the genetics of congenital hyperinsulinism

A number of congenital disorders characterized by low blood sugar levels (hypoglycemia) as a result of excessive secretion of the hormone insulin are collectively known as congenital hyperinsulinism. These disorders are caused by genetic mutations that result in mutant
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