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JCI online early table of contents: January 4, 2009
Date:1/4/2010

E-mail: nsims@svi.edu.au.

View this article at: http://www.jci.org/articles/view/40568?key=ac1b87b02dc3a7eb8e5a


IMMUNOLOGY: Dampening CD4+ immune cell function via the protein TLR4

The immune system uses a large number of proteins to sense the presence of microbes, including a family of proteins known as TLRs. The function of TLRs on immune cells known as DCs and macrophages has been well characterized, but the role of TLR4 on immune cells known as CD4+ T cells has not been determined. However, Jos M. Gonzlez-Navajas, Eyal Raz and colleagues, at the University of California at San Diego, La Jolla, have now determined that triggering TLR4 on CD4+ T cells dampens their inflammatory function, as TLR4 deficiency in two mouse models of colitis (inflammation of the intestines) accelerated the development of disease and/or induced more severe disease. Further analysis identified a molecular signaling pathway underlying the inhibitory effects of TLR4 triggering on CD4+ T cell inflammatory function, providing insight into the regulation of CD4+ T cell responses.

TITLE: TLR4 signaling in effector CD4+ T cells regulates TCR activation and experimental colitis in mice

AUTHOR CONTACT:
Jos M. Gonzlez-Navajas
The University of California at San Diego, La Jolla, California, USA.
Phone: (858) 534-5380; Fax: (858) 534-0409; E-mail: jog001@ucsd.edu.

Eyal Raz
The University of California at San Diego, La Jolla, California, USA.
Phone: (858) 534-5444; Fax: (858) 534-0409; E-mail: eraz@ucsd.edu.

View this article at: http://www.jci.org/articles/view/40055?key=4fd8a3cbae6e3101db58


CARDIOLOGY: It's good
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Contact: Karen Honey
press_releases@the-jci.org
215-573-1850
Journal of Clinical Investigation
Source:Eurekalert

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