Navigation Links
JCI online early table of contents: January 4, 2009
Date:1/4/2010

E-mail: nsims@svi.edu.au.

View this article at: http://www.jci.org/articles/view/40568?key=ac1b87b02dc3a7eb8e5a


IMMUNOLOGY: Dampening CD4+ immune cell function via the protein TLR4

The immune system uses a large number of proteins to sense the presence of microbes, including a family of proteins known as TLRs. The function of TLRs on immune cells known as DCs and macrophages has been well characterized, but the role of TLR4 on immune cells known as CD4+ T cells has not been determined. However, Jos M. Gonzlez-Navajas, Eyal Raz and colleagues, at the University of California at San Diego, La Jolla, have now determined that triggering TLR4 on CD4+ T cells dampens their inflammatory function, as TLR4 deficiency in two mouse models of colitis (inflammation of the intestines) accelerated the development of disease and/or induced more severe disease. Further analysis identified a molecular signaling pathway underlying the inhibitory effects of TLR4 triggering on CD4+ T cell inflammatory function, providing insight into the regulation of CD4+ T cell responses.

TITLE: TLR4 signaling in effector CD4+ T cells regulates TCR activation and experimental colitis in mice

AUTHOR CONTACT:
Jos M. Gonzlez-Navajas
The University of California at San Diego, La Jolla, California, USA.
Phone: (858) 534-5380; Fax: (858) 534-0409; E-mail: jog001@ucsd.edu.

Eyal Raz
The University of California at San Diego, La Jolla, California, USA.
Phone: (858) 534-5444; Fax: (858) 534-0409; E-mail: eraz@ucsd.edu.

View this article at: http://www.jci.org/articles/view/40055?key=4fd8a3cbae6e3101db58


CARDIOLOGY: It's good
'/>"/>

Contact: Karen Honey
press_releases@the-jci.org
215-573-1850
Journal of Clinical Investigation
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. Small Businesses In Singapore Outmarkets & Outperforms Bigger Players in Tough Economy With Online Marketing
2. Jackson & Coker Produces Online Video Holiday Message for Hospitals and Medical Providers
3. MediBid.com Empowers Physicians to Expand Their Fee for Service Practice with New Online Portal
4. New Online Program Gives Parents and Schools an Innovative Tool to Prevent Substance Use Among Youth
5. Online Fitness Tracking Program Integrates With Garmin Fitness Activity Monitors
6. Doc's Nutrition Depot NY, Reports New and Exciting Changes To Their Online Website to Improve Your Shopping Experience
7. Bella Sante Spas in Boston Reports Online Spending Rise of 12 percent December 1 to December 17, 2009
8. Streamline Your Holiday Shopping With Online Savings At Ravalmd.com
9. A World-Class HR Master's Degree Is Now Within Reach – 100% Online
10. New Online Beauty Store Suggests Stem Cells for the Woman Who Has Everything
11. Wiley-Blackwell launches new online medical reference tool -- Essential Evidence
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/23/2014)... TX (PRWEB) July 23, 2014 Ticket ... vs. AS Roma tickets in Dallas, TX at the ... eight team tournament held in the United States and Canada ... the world including teams from La Liga, Serie A, English ... year are Manchester United, Manchester City, Olympiacos, Inter Milan, Liverpool, ...
(Date:7/23/2014)... 23, 2014 Recently, Agebc.com has launched ... the company is announcing a promotion of wedding dresses. ... will end at the end of this month. , ... popular styles, like A-line, mermaid, ball-gown, empire, and more. ... and other special-occasion dresses for women, and the company ...
(Date:7/23/2014)... Battle Creek, MI (PRWEB) July 23, 2014 ... treatment program that gets clients off to a great ... they can believe in, has launched a new Internet ... , “Many people are surprised to learn that Internet ... sexual addiction or drug addiction, but that it’s trapping ...
(Date:7/23/2014)... Pallarito HealthDay Reporter TUESDAY, ... for Obamacare, two federal appeals courts arrived at completely different ... millions of Americans who bought health insurance through the federal ... is headed for a showdown before the U.S. Supreme Court. ... Court for the District of Columbia Circuit said that the ...
(Date:7/23/2014)... arriving at the emergency department, the drug ketamine ... rapid, life-saving intubation, despite decades-old studies that suggested ... a systematic review of 10 recent studies of ... drug" are published online in Annals of ... on Intracranial and Cerebral Perfusion Pressure and Health ...
Breaking Medicine News(10 mins):Health News:Real Madrid vs. AS Roma Tickets Cotton Bowl Dallas, TX: Ticket Down Slashes Ticket Prices on all AS Roma vs. Real Madrid International Champions Cup Tickets 2Health News:Real Madrid vs. AS Roma Tickets Cotton Bowl Dallas, TX: Ticket Down Slashes Ticket Prices on all AS Roma vs. Real Madrid International Champions Cup Tickets 3Health News:Agebc.com Launched Its New Collection of Wedding Dresses 2Health News:Latest A Forever Recovery Launches Internet Addiction Section on Website 2Health News:2 Courts, 2 Different Decisions on Key Obamacare Provision 2Health News:2 Courts, 2 Different Decisions on Key Obamacare Provision 3Health News:Ketamine can be a wonder drug for ER patients and their physicians 2
... (HealthDay News) -- A gene variant associated with asthma ... of researchers working together in a new national collaboration ... was not present in European Americans and may be ... in black Americans. The researchers, analysis of data ...
... August issue of the Journal of the American College ... in head computed tomography (CT) scans. Head CT is the ... the total number of CT examinations. Magnetic resonance imaging ... a vast majority of brain and spinal indications. However, CT ...
... (HealthDay News) -- Several biomechanical differences appear to separate ... could the study identify ways for recreational golfers to ... said the Stanford University School of Medicine team that ... cameras to analyze the full golf swings -- from ...
... Laxenburg, Austria 28 July 2011 -- Future trends ... improvements in both the quality and quantity of education, ... do not explicitly include education in their analysis may ... journal Science (July 29 2011). ...
... FRIDAY, July 29 (HealthDay News) -- A growing number of ... in which they spend three or more nights together each ... own homes, a new study shows. "Instead of following ... to engage in romantic ties on their own terms ...
... will begin a Phase 1 clinical trial on a ... represents the first new class of anti-TB drugs in ... both drug-susceptible and drug-resistant TB. The study is ... awarded from the National Institutes of Health through the ...
Cached Medicine News:Health News:Education -- a key determinant of population growth and human well-being 2Health News:Education -- a key determinant of population growth and human well-being 3Health News:Even Living Together Is Too Much Commitment for Today's Couples 2
(Date:7/23/2014)... DALLAS , July 23, 2014 ... LLC ("Plaintiff") filed suit in the 116 ... Dallas, Texas , against RegenLab USA, ... Current and Prospective Business Relationships through false ... interference; and, Business Disparagement through libel, ...
(Date:7/23/2014)... Use of Risk Evaluation and Mitigation Strategies (REMS) and ... results in $5.4 billion in lost savings annually, according ... economic consulting firm Matrix Global Advisors (MGA). ... Required by the Food and Drug Administration (FDA) for ... to improve drug safety by ensuring that the benefits ...
(Date:7/23/2014)... 23, 2014 PositiveID Corp. (OTCQB: PSID), based ... is an emerging player in the bio-threat detection ... detection and rapid medical testing. The Company,s proprietary ... Autonomous Networked Detector), was developed under contract with ... & Technology directorate, and $30 million of contract ...
Breaking Medicine Technology:New Analysis Finds $5.4 Billion In Annual Lost Savings From Strategies Geared Toward Delaying Generic Drug Entry 2PositiveID Analyst Inspection: Emerging Contender in BioThreat Detection - First Ever Revenue Guidance and Backlog Position Company for Increased Visibility and Traction - by SmallCapTraders.com 2
... The U.S. Food and Drug Administration today ... metastatic breast cancer who have received at least ... (Logo: http://photos.prnewswire.com/prnh/20090824/FDALOGO ) (Logo: ... the second leading cause of cancer related death ...
... Millennium Research Group (MRG), the global authority ... latest peripheral vascular research data for multiple geographies, ... Latin America. MRG,s peripheral vascular reports ... artery disease, including stenting, percutaneous transluminal balloon angioplasty, ...
Cached Medicine Technology:FDA Approves New Treatment Option for Late-Stage Breast Cancer 2New Peripheral Vascular Device Market Research Data Covering Multiple Geographies Released by Millennium Research Group 2
... The Cadwell Cascade is a powerful, multi-modality system ... free-run EMG, stimulated EMG, EEG, and train of ... with portability as a priority. The base weighs ... weighs just 13 lbs. A desktop PC-based system ...
... Endeavor is a neuromonitoring system especially ... monitoring. Endeavor amplifier has 16 channels and ... active electrode inputs. Each channel can be ... or a true differential channel. Endeavor amplifiers ...
... Katena Products, Inc. is the ... dedicated exclusively to ophthalmic surgical ... to over 7,000 customers in ... a global network of distributors, ...
... Blood glucose, medication, food, exercise, stress . ... a diabetes patients overall health. Unfortunately, its ... this vital information on a daily basis. ... day-to-day results or submit the information to ...
Medicine Products: