Navigation Links
JCI online early table of contents: Jan. 9, 2012
Date:1/9/2012

chromosomal irregularity arises in a blood cell stem or early progenitor cell. CML has several phases the first phase, when there are few symptoms of disease, can last for years, but it eventually progresses to much more dangerous second and third phases. A team of researchers led by Adrian Ochsenbein, at University Hospital Bern, Switzerland, has now identified a role for the protein CD27 on CML stem cells in progression of disease in a mouse model of CML. Importantly, blocking CD27 delayed disease progression and prolonged survival. Ochsenbein and colleagues therefore suggest that blocking CD27 or targeting the signaling pathway downstream of its activation might provide a new therapeutic option for the treatment of individuals with CML. New treatment options are needed for this disease because even though the current first-line treatment (a drug known as imatinib [Gleevec]) is highly effective in the majority of patients, in about 10%󈝻% of patients the beneficial effects of Gleevec are very short lived.

TITLE: CD27 signaling on chronic myelogenous leukemia stem cells activates Wnt target genes and promotes disease progression

AUTHOR CONTACT:
Adrian F. Ochsenbein
Institute for Medical Oncology, University Hospital Bern, Bern, Switzerland.
Phone: 41-31-632-4114; Fax: 41-31-632-4119; E-mail: adrian.ochsenbein@insel.ch.

View this article at:
http://www.jci.org/articles/view/45977?key=f581a987f6fdcd642407

ALLERGY AND ASTHMA: Integrin integral to airway narrowing

More than 10 million Americans suffer from the most common form of asthma allergic asthma. A team of researchers led by Dean Sheppard, at the University of California, San Francisco, San Francisco, has now gained new insight into the mechanisms underlying the airway narrowing that occurs during an asthma
'/>"/>

Contact: Karen Honey
press_releases@the-jci.org
734-546-5242
Journal of Clinical Investigation
Source:Eurekalert

Page: 1 2 3 4 5 6 7

Related medicine news :

1. TheReliefPlace.com Launches Online Store “The Relief Shop” - What Does this Medical Supply Store Carry and How Can They Help You?
2. Web Content Management Enables Government Transparency, Participation, and Collaboration Online
3. DavisPTnetwork Partners with the New York Physical Therapy Association to Provide Online Continuing Education
4. PERSONALABS Offers Discounted Healthy Heart Online Blood Tests in February
5. Pharmahelper Pleased To Recognize Online Pharmacy Practice Standards Announced By Google Adwords
6. Online Dating Reinvents Itself with the Recent Roll-Out of Teacherhookup.com, a Free Website that Focuses on a Person's Career in Education!
7. EdenHome.com Adds Aventura Organic Clothes to Site and Announces Largest Online Selection of Stylish Organic Clothes for Men, Women and Children
8. Fire Protection Online Resolves Safety Concerns with CO2 Fire Extinguishers
9. JCI online early table of contents: Feb. 15, 2010
10. Fitness Trend Towards Online Personal Training Gets Real-World Weight Loss Results on FitOrbit.com
11. New Online Store Makes Buying Cosmetics a Healthy Choice
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/1/2015)... ... September 01, 2015 , ... Suzanne Bakken, PhD, RN, FAAN, ... Institute of Medicine (IOM) of the National Academies. , She is the Alumni ... Nursing. A member of the Institute of Medicine since 2006, Bakken also currently ...
(Date:9/1/2015)... ... September 01, 2015 , ... Ogawa’s new massage chairs ... robots more effective and humanlike than ever before. With the goal of bringing wellness ... and the Ogawa Active SuperTrac. , As in its name, the Ogawa ...
(Date:9/1/2015)... ... September 01, 2015 , ... Situations requiring fast, easy-to-understand ... the most convenient time for everyone involved. These occasions highlight the value of ... Translation Services has real people available to handle any translation assignment at ...
(Date:9/1/2015)... CINCINNATI, OHIO (PRWEB) , ... September 01, 2015 , ... ... US today at JourneyLite of Cincinnati. In the last month the FDA has ... ReShape Duo ™. These procedures represent the first incisionless, reversible, weight loss ...
(Date:9/1/2015)... TN (PRWEB) , ... September 01, 2015 , ... ... users to send information about new patients directly from Practice Perfect to FOTO ... duplicate data entry. , Steven Presement, President of Practice Perfect, ...
Breaking Medicine News(10 mins):Health News:Columbia Nursing’s Suzanne Bakken Named Distinguished Institute of Medicine Nurse Scholar-in-Residence 2Health News:Ogawa World USA Releases New Massage Chairs to the US 2Health News:Ogawa World USA Releases New Massage Chairs to the US 3Health News:Universal Translation Services Provides Quality Translations 24 Hours a Day Including Weekends 2Health News:Universal Translation Services Provides Quality Translations 24 Hours a Day Including Weekends 3Health News:Dr. Trace Curry Performs First ORBERA™ Intra-gastric Balloon in Ohio at JourneyLite, a New Incisionless Option For The Treatment of Obesity 2Health News:FOTO Announces New Integration Partnership with Practice Perfect 2
... ... proprietary Figure-Eight™ Technology, new CirQlation™ Elite offers vibration massage and ability to convert into ... ... U.S. market leader of innovative massage chairs , Perfect Chair® Recliners and other ...
... Patients taking Lexapro had better thinking, learning and memory ... MONDAY, Feb. 1 (HealthDay News) -- Taking antidepressants after ... improve mental functioning, a new study suggests. , Little ... abilities, such as thinking, learning and memory, after initial ...
... , , ... vaccine development , SILVER SPRING, Md. , ... (FDA) today announced a collaboration with PATH to advance development ... Streptococcus pneumoniae (pneumococcus), especially pneumonia. , (Logo: ...
... , Oral ... CHICAGO , Feb. 1 February is ... of the important role early dental care plays in children,s overall ... take action early to insure the health of their children,s teeth ...
... innate interest in the new and different may help ... published by the American Psychological Association. In controlled experiments, ... got cocaine. Novelty could help break the ... many addicts with novelty-craving, risk-taking personalities, the authors said. ...
... ... (CFO) of Santen Inc., as its 2010 president. , ... San Francisco (Vocus) -- Ophthalmic Women Leaders (OWL) ... president., , , , ,Prior to her appointment as president, Gleeson previously served as ...
Cached Medicine News:Health News:Human Touch Introduces New CirQlation™ Elite Foot & Calf Massager Providing Ultimate Targeted Relief for Tired Feet and Calves 2Health News:Human Touch Introduces New CirQlation™ Elite Foot & Calf Massager Providing Ultimate Targeted Relief for Tired Feet and Calves 3Health News:Human Touch Introduces New CirQlation™ Elite Foot & Calf Massager Providing Ultimate Targeted Relief for Tired Feet and Calves 4Health News:Antidepressants After Stroke May Boost Mental Ability 2Health News:Antidepressants After Stroke May Boost Mental Ability 3Health News:FDA Collaboration Seeks to Speed Development of Pneumococcal Vaccines for Children in Developing Countries 2Health News:FDA Collaboration Seeks to Speed Development of Pneumococcal Vaccines for Children in Developing Countries 3Health News:February Is National Children's Dental Health Month 2Health News:February Is National Children's Dental Health Month 3Health News:February Is National Children's Dental Health Month 4Health News:Novelty lures rats from cocaine-paired settings, hinting at new treatments for recovering addicts 2Health News:Novelty lures rats from cocaine-paired settings, hinting at new treatments for recovering addicts 3Health News:Ophthalmic Women Leaders (OWL) Names Pamela Gleeson, CFO Of Santen Inc., as 2010 President 2
(Date:8/31/2015)... Premune and Innovet ... licensing agreement for Redonyl ® Ultra. The product, ... veterinary dermatology market, is a nutritional supplement based on ... in dogs and cats. Redonyl ® Ultra is ... has been received positively in the country by veterinarians ...
(Date:8/31/2015)... PLEASANTON, Calif. , Aug. 31, 2015  QT Vascular ... "QT Vascular", and together with its subsidiaries, the ... assembly and distribution of advanced therapeutic solutions for ... today the final results of the below-the-knee ("BTK") ... Registry ("BAR") which were presented on August 15, ...
(Date:8/31/2015)... Aug. 31, 2015   BioLife Solutions , ... manufacturer and marketer of proprietary clinical grade cell ... cryopreservation freeze media and a related ... for smart shippers ("BioLife" or the ... an advanced biopharmaceutical company focused on developing and ...
Breaking Medicine Technology:Premune Broadens Portfolio With Novel Innovet Skin Health Product 2Premune Broadens Portfolio With Novel Innovet Skin Health Product 3Premune Broadens Portfolio With Novel Innovet Skin Health Product 4Final Results From Below-The-Knee Cohort In Chocolate Registry Presented At The 5th Annual Amputation Prevention Conference 2Final Results From Below-The-Knee Cohort In Chocolate Registry Presented At The 5th Annual Amputation Prevention Conference 3Final Results From Below-The-Knee Cohort In Chocolate Registry Presented At The 5th Annual Amputation Prevention Conference 4BioLife Solutions Customer TiGenix Phase 3 Clinical Trial Meets Primary Endpoint 2BioLife Solutions Customer TiGenix Phase 3 Clinical Trial Meets Primary Endpoint 3BioLife Solutions Customer TiGenix Phase 3 Clinical Trial Meets Primary Endpoint 4BioLife Solutions Customer TiGenix Phase 3 Clinical Trial Meets Primary Endpoint 5
... Va., Feb. 9, 2011 With generous funding ... Palliative Care Association are partnering to improve pain ... hospitals in The Gambia, Kenya, and Malawi. ... they each have well-established national palliative care organizations, ...
... Design Trends: Technological Advances in Implantable Devices, a UBM Canon Medical Device ... Industry ( MD+DI ) , ... , and OrthoTec , is now on-demand ... 1,092, with an attendance of 50% during the live event held on ...
Cached Medicine Technology:FHSSA and the African Palliative Care Association Launch the First-Ever Pain Management Initiative in The Gambia, Kenya, and Malawi 2Now Available: Archived Virtual Event Dedicated to Cutting-Edge Trends in Implantable Medical Devices 2Now Available: Archived Virtual Event Dedicated to Cutting-Edge Trends in Implantable Medical Devices 3
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: