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JCI online early table of contents: Jan. 9, 2012
Date:1/9/2012

chromosomal irregularity arises in a blood cell stem or early progenitor cell. CML has several phases the first phase, when there are few symptoms of disease, can last for years, but it eventually progresses to much more dangerous second and third phases. A team of researchers led by Adrian Ochsenbein, at University Hospital Bern, Switzerland, has now identified a role for the protein CD27 on CML stem cells in progression of disease in a mouse model of CML. Importantly, blocking CD27 delayed disease progression and prolonged survival. Ochsenbein and colleagues therefore suggest that blocking CD27 or targeting the signaling pathway downstream of its activation might provide a new therapeutic option for the treatment of individuals with CML. New treatment options are needed for this disease because even though the current first-line treatment (a drug known as imatinib [Gleevec]) is highly effective in the majority of patients, in about 10%󈝻% of patients the beneficial effects of Gleevec are very short lived.

TITLE: CD27 signaling on chronic myelogenous leukemia stem cells activates Wnt target genes and promotes disease progression

AUTHOR CONTACT:
Adrian F. Ochsenbein
Institute for Medical Oncology, University Hospital Bern, Bern, Switzerland.
Phone: 41-31-632-4114; Fax: 41-31-632-4119; E-mail: adrian.ochsenbein@insel.ch.

View this article at:
http://www.jci.org/articles/view/45977?key=f581a987f6fdcd642407

ALLERGY AND ASTHMA: Integrin integral to airway narrowing

More than 10 million Americans suffer from the most common form of asthma allergic asthma. A team of researchers led by Dean Sheppard, at the University of California, San Francisco, San Francisco, has now gained new insight into the mechanisms underlying the airway narrowing that occurs during an asthma
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Contact: Karen Honey
press_releases@the-jci.org
734-546-5242
Journal of Clinical Investigation
Source:Eurekalert

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