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JCI online early table of contents: Jan. 9, 2012
Date:1/9/2012

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The outlook for individuals diagnosed with the most common form of pancreatic cancer, pancreatic ductal adenocarcinoma (PDA), is very poor; the average time of survival after diagnosis is less than 6 months. New therapeutic approaches are therefore much needed. By developing and studying two new mouse models of pancreatic cancer, a team of researchers led by Marina Pasca di Magliano, at the University of Michigan, Ann Arbor, has now identified potential new targets for treating individuals with this terminal condition.

Mutations in the KRAS gene are detectable in the majority of pancreatic cancers. However, the relative importance of these mutations in promoting the formation of and maintaining the presence of pancreatic cancers is not completely understood. Pasca di Magliano and colleagues have now generated data that indicate that KRAS mutations drive the formation of pancreatic tumors in mice and are essential for the maintenance of these tumors. They therefore suggest that inhibiting the constitutively active form of KRAS templated by mutated KRAS genes and/or molecules activated by the mutant KRAS could provide much needed new approaches for the treatment of pancreatic cancer.

TITLE: Oncogenic Kras is required for both the initiation and maintenance of pancreatic cancer in mice

AUTHOR CONTACT:
Marina Pasca di Magliano
University of Michigan, Ann Arbor, Michigan, USA.
Phone: 734-615-7424; Fax: 734-647-9654; E-mail: marinapa@umich.edu.

View this article at:
http://www.jci.org/articles/view/59227?key=ea2a2976eda990b97f6f

HEMATOLOGY: Potential new therapeutic target for chronic myelogenous leukemia?

Chronic myelogenous leukemia (CML) is a slow-growing bone marrow cancer resulting in the overproduction of white blood cells. It is triggered when a specific
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Journal of Clinical Investigation
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