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JCI online early table of contents: Jan. 2, 2008
Date:1/2/2008

s CD4+ T cells protects mice from disease in a mouse model of multiple sclerosis. Now, Mohamed Sayegh and colleagues from Harvard Medical School, Boston, have shown that a short course of this antibody prolongs the survival of nongenetically identical heart transplants (allografts) in mice. If treatment with the TIM-1specific antibody was combined with subtherapeutic doses of the immunosuppressive drug rapamycin the allografts were not rejected for the length of the study. The mechanisms underlying the effects of the TIM-1specific antibody were found to involve inhibition of alloreactive Th1 responses and preservation of Th2 responses. In addition, regulatory T cells were also shown to have a central role, as if mice were depleted of these cells prior to transplantation the TIM-1specific antibody failed to prolong allograft survival. The authors therefore suggested that TIM-1specific antibody therapy might provide a new approach to preventing transplant rejection.

TITLE: The emerging role of T cell Ig mucin 1 in alloimmune responses in an experimental mouse transplant model

AUTHOR CONTACT:
Mohamed H. Sayegh
Brigham and Womens Hospital, and Childrens Hospital Boston, Harvard Medical School, Boston, Massachusetts, USA.
Phone: (617) 732-5259; Fax: (617) 732-5254; E-mail: msayegh@rics.bwh.harvard.edu.

View the PDF of this article at: https://www.the-jci.org/article.php?id=32451


NEPHROLOGY

It is no use sugar coating it: IgA1 is prematurely sialylated in individuals with IgA nephropathy

Among individuals with the relatively common kidney disease IgA nephropathy, 2040% go on to develop end-stage kidney disease. The disease is characterized by the accumulation of immune complexes in small clusters of capillaries in the kidneys known as glomeruli. The antibodies in these im
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Contact: Karen Honey
press_releases@the-jci.org
215-573-1850
Journal of Clinical Investigation
Source:Eurekalert

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