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JCI online early table of contents: Jan. 2, 2008
Date:1/2/2008

e surgical intervention dangerous. In a new study, Aernout Luttun and colleagues from the Katholieke Universiteit Leuven, Belgium, investigated the potential for multipotent adult progenitor cells (MAPCs) to improve the function of mouse tissues damaged by PVD.

MAPCs are immature cells in an adult organism that give rise to several different cell types, through a process known as differentiation. The authors investigated the effect that two different mouse progenitor cell populations undifferentiated MAPCs (MAPC-Us) and vascular progenitor cells derived from MAPCs (MAPC-VPs) had on mice with moderate or severe limb ischemia. When injected into mice with a moderate ischemia similar to IC in humans, mouse MAPC-Us restored blood flow and muscle function, and stimulated muscle regeneration. In contrast, neither mouse MAPC-VPs nor mouse BMCs (bone marrowderived, non-progenitor cells) caused muscle regeneration. Further analysis revealed that both mouse and human MAPC-Us improved muscle function and restored blood flow in mice with a severe limb ischemia similar to CLI in humans. From these results, the authors concluded that undifferentiated MAPCs might have the potential to repair damage due to vessel obstruction in patients with PVD.

TITLE: Multipotent adult progenitor cells sustain function of ischemic limbs in mice

AUTHOR CONTACT:
Aernout Luttun
Katholieke Universiteit Leuven, Leuven, Belgium.
Phone: 32-16-34-57-72; Fax: 32-16-34-59-90; E-mail: aernout.luttun@med.kuleuven.be.

View the PDF of this article at: https://www.the-jci.org/article.php?id=31153


TRANSPLANTATION

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Journal of Clinical Investigation
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