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JCI online early table of contents: Jan. 2, 2008
Date:1/2/2008

not been well understood. A new study by Carla Nau and her colleagues at Friedrich-Alexander-University of Erlangen-Nuremberg, Germany, has revealed that lidocaine interacts with neurons through TRVP1, an ion channel that is responsible for activation of the pain-sensing sensory neurons. Lidocaine activated TRVP1 located on both rodent neurons and a human cell line. When applied to either isolated mouse skin or sciatic nerves, lidocaine induced TRVP1-mediated release of the peptide CGRP, a key component in inflammation of the nerves. These data led the authors to conclude that TRVP1 is likely to be a key component of LA-associated neurotoxicity, although further investigations are required to pin-point the role of TRVP1 in LA-induced neurotoxicity.

TITLE: The vanilloid receptor TRPV1 is activated and sensitized by local anesthetics in rodent sensory neurons

AUTHOR CONTACT:
Carla Nau
Friedrich-Alexander-University of Erlangen-Nuremberg, Erlangen, Germany.
Phone: +49-9131-85-39154; Fax: +49-9131-85-39161; E-mail: carla.nau@kfa.imed.uni-erlangen.de.

View the PDF of this article at: https://www.the-jci.org/article.php?id=32751


VASCULAR BIOLOGY

Adult multipotent progenitor cells ProViDe hope to patients with peripheral vascular disease

Peripheral vascular disease (PVD) is a disease of the limbs caused by obstruction of the blood vessels. Moderate PVD causes pain when walking, which is known clinically as intermittent claudication (IC); while patients with severe disease have decreased blood and oxygen flow in the limbs (critical limb ischemia [CLI]) that can result in tissue injury or death. Although treatments exist, such as surgically bypassing or opening the obstructed blood vessel, many patients with moderate-to-severe PVD often have underlying disorders that mak
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Contact: Karen Honey
press_releases@the-jci.org
215-573-1850
Journal of Clinical Investigation
Source:Eurekalert

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