Navigation Links
JCI online early table of contents: Jan. 2, 2008
Date:1/2/2008

and tumor suppressor genes, respectively. Because various cancers are associated with the deletion of a particular portion of the genome containing AHRR, scientists believe that a tumor suppressor gene is located in that region. A new study by Enrique Zudaire and his colleagues at the National Cancer Institute, Bethesda, has provided evidence that AHRR has tumor suppressor capabilities in a variety of human cancers.

In the study, AHRR gene expression was found to be decreased in cancerous human tissues from various organs including colon, breast, lung, stomach, cervix, and ovary. Artificial suppression of AHRR gene expression in human lung cancer cells using siRNA technology resulted in enhanced tumor cell proliferation, both in culture and when the cells were transplanted into immunocompromised mice. These AHRR-silenced cells also were protected against a form of cell death known as apoptosis, as well as having enhanced migratory and invasive behavior. Finally, overexpression of AHRR in human lung cancer cells resulted in decreased proliferation. The authors therefore concluded from these data that AHRR is a tumor suppressor gene present in various tissues.

TITLE: The aryl hydrocarbon receptor repressor is a putative tumor suppressor gene in multiple human cancers

AUTHOR CONTACT:
Enrique Zudaire
National Cancer Institute, Bethesda, Maryland, USA.
Phone: (301) 496-8050; Fax: (301) 435-8036; E-mail: zudairee@mail.nih.gov.

View the PDF of this article at: https://www.the-jci.org/article.php?id=30024


BONE BIOLOGY

Softly, softly: Phex gene mutation in mouse bone cells causes rickets

X-linked hypophosphatemia (XLH) is the most common form of inherited rickets, a disease characterized by softening of the bones. It is caused by a mutation in the PHEX gene. Mice with a m
'/>"/>

Contact: Karen Honey
press_releases@the-jci.org
215-573-1850
Journal of Clinical Investigation
Source:Eurekalert

Page: 1 2 3 4 5 6 7 8 9

Related medicine news :

1. HIV denialists spread misinformation online -- consequences could be deadly; and more
2. Consequences of online HIV denial; and more
3. Online Epidemic Gives Clues to Bird Flu Spread
4. MedHelp to Add Top Stanford Surgeons and Specialized Forums to Online Health Community
5. Online Celebrity Shoe Charity Auction for Womens Heart Health Opens Bidding
6. Syndicom to Launch Online Community for DePuy Spine
7. Elder Caregiving Site ShirleyBOARD.com Wins WebAward for Outstanding Online Community
8. Peer-Reviewed, Online Database Showcases Local, County and State Pandemic Planning
9. CIGNA Behavioral Health Offers Members Online Provider Profiles
10. Dynamic Energy Systems Goes Online and On-Demand
11. North Shore-LIJ Health System Begins Online Posting of Hospital Infection Rates, Other Performance Information
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2015)... Rochester, N.Y. (PRWEB) , ... July 31, 2015 ... ... Brand, is proud to announce that their latest designer handbag line will be ... recently become an Internet sensation as the first globally recognized model with Down ...
(Date:7/31/2015)... ... ... Ticket Down is a reputable source of authentic USA vs. Australia tickets at ... Women's National Team in conjunction with their Victory Tour to celebrate winning the 2015 Women's ... USA team was awarded the Golden Ball as the best player of the 2015 Women's ...
(Date:7/31/2015)... ... July 31, 2015 , ... Eldermark Software, the ... Center for Aging Services Technologies (CAST) Medication Management Technologies whitepaper. The whitepaper is ... providers understand the benefits of using medication management technologies . ...
(Date:7/31/2015)... (PRWEB) , ... July 31, 2015 , ... ZH Healthcare ... OSEHRA 2015. , What is HITaaS? Health IT as a Service (HITaaS) is a ... software as a service (SaaS). , HITaaS manages all aspects of ...
(Date:7/31/2015)... ... July 31, 2015 , ... Physical therapy for knee osteoarthritis is an ... life. It keeps the patient from doing what they want or need to do. The ... time using the stairs. The patient's exercise regime may be limited by the pain in ...
Breaking Medicine News(10 mins):Health News:everMaya to Launch Madeline Stuart Handbag Line 2Health News:everMaya to Launch Madeline Stuart Handbag Line 3Health News:Cheap USA vs. Australia Tickets at Ford Field in Detroit, MI: Ticket Down Slashes Ticket Prices for Australia vs. USWNT International Friendly Match at Ford Field 2Health News:LeadingAge Selects Eldermark Case Study to Highlight Medication Error Reduction Results 2Health News:LeadingAge Selects Eldermark Case Study to Highlight Medication Error Reduction Results 3Health News:ZH Healthcare Unveils Health IT as a Service (HITaaS) at OSEHRA 2015 2Health News:ZH Healthcare Unveils Health IT as a Service (HITaaS) at OSEHRA 2015 3Health News:ZH Healthcare Unveils Health IT as a Service (HITaaS) at OSEHRA 2015 4Health News:NYDNRehab Is the First Clinic in NYC to Provide APOS Therapy Based on Results of Complete Gait Analysis 2Health News:NYDNRehab Is the First Clinic in NYC to Provide APOS Therapy Based on Results of Complete Gait Analysis 3
... lacked this type of service within past year, study ... American teens don,t receive the appropriate amount of preventive ... establish good health behaviors and discourage damaging behaviors that ... a new study finds. , The University of California, ...
... Loss Costs Economy up to $15 Billion Each Year According ... than ever, Americans need their shut-eye. Unfortunately, sleep is usually ... is short and stress is high. In a turbulent economy, ... a few nights per week , according to a 2009 ...
... (Nasdaq: AMLN ) today announced its director ... Stockholders. Over the past several months, the Company,s Corporate ... in a rigorous process to identify a slate of ... believes will best serve the interests of all Amylin ...
... SAN DIEGO, March 30 NuVasive, Inc. (Nasdaq: ... developing products for minimally disruptive surgical treatments for the ... of the supply of Osteocel, NuVasive has accelerated the ... Therapeutics (Nasdaq: OSIR ) to its own ...
... Including Completing CE Mark, Application for ... (TSXV: NVC) today announced that it intends to undertake ... at the price of $0.21 per unit for aggregate ... offering will be used for continued development of a ...
... (Nasdaq: LCAV ), a leading provider of ... brand, today announced that, according to a March 26, ... dissident Joffe Group announced it has terminated its solicitation ... Group has disbanded. Additionally, the Joffe Group stated ...
Cached Medicine News:Health News:Most Teens Aren't Getting Preventive Health Care 2Health News:It Pays to Sleep: Prioritize Rest to Boost Health, Morale and Revenue 2Health News:It Pays to Sleep: Prioritize Rest to Boost Health, Morale and Revenue 3Health News:Amylin Pharmaceuticals Announces Slate of Directors for Annual Meeting of Stockholders 2Health News:Amylin Pharmaceuticals Announces Slate of Directors for Annual Meeting of Stockholders 3Health News:Amylin Pharmaceuticals Announces Slate of Directors for Annual Meeting of Stockholders 4Health News:Long Term Supply of Osteocel(R) Plus Solidified Without Ownership of Processing Facility 2Health News:Long Term Supply of Osteocel(R) Plus Solidified Without Ownership of Processing Facility 3Health News:Long Term Supply of Osteocel(R) Plus Solidified Without Ownership of Processing Facility 4Health News:Neovasc to Raise $2 Million in Non-Brokered Private Placement 2Health News:Neovasc to Raise $2 Million in Non-Brokered Private Placement 3Health News:LCA-Vision Announces Termination of Consent Solicitation and Withdrawal of Dissident Slate of Director Nominees 2
(Date:7/31/2015)... Magnaquest, a leading Subscription ... cloud computing operators has signed a Proof of ... Internet of Things (IoT) related initiative. The PoC ... model.      (Logo: http://photos.prnewswire.com/prnh/20140807/700645 ) ... business innovations to make healthcare services more accessible ...
(Date:7/30/2015)...  ResMed Inc. (NYSE: RMD ) today announced ... for the quarter was $453.1 million, a 9 percent ... (a 17 percent increase on a constant currency basis). ... ended June 30, 2014.  Diluted earnings per share for ... June 30, 2014.  The results for ...
(Date:7/30/2015)... and VANCOUVER , July ... ) announced today that it will report its second ... Company management will host a conference call and live ... overview of financial results, clinical development programs and a ... webcast, log on to the Investor Relations page of ...
Breaking Medicine Technology:Magnaquest Signs a POC With a Leading Pharma Giant in Europe to Manage Subscription Management and Billing for Internet of Things (IoT) 2ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 2ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 3ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 4ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 5ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 6ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 7ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 8ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 9ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 10ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 11ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 12ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 13ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 14ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 15ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 16
... MedImmune today announced,that it has initiated a Phase 1/2a ... children one month to 12 months of age to,help ... most common respiratory infection in infants and can cause ... a serious respiratory disease that can have significant effects,on ...
... Partner to Make Direct Investment in CEL-SCI, ... CVM ) announced today that it has expanded ... Co., Ltd. ("Orient,Europharma"), a leading pharmaceutical company from ... also cover South Korea,the Philippines, Australia and New ...
Cached Medicine Technology:MedImmune Advances Pediatric Disease Prevention Program With Start of Phase 1/2a Clinical Trial for Respiratory Syncytial Virus Vaccine 2CEL-SCI Announces Expansion of Exclusive Licensing Agreement for Cancer Drug Multikine 2CEL-SCI Announces Expansion of Exclusive Licensing Agreement for Cancer Drug Multikine 3
... Reusable Purstring Device for use ... Biofragmentable Anastomosis Ring)., ,The ... intestinal, colorectal and esophageal surgery ... string sutures and is intended ...
The Auto Suture™ EEA™ 34mm reusable stainless steel sizer has application in intestinal, colorectal and esophageal surgery to help evaluate the diameter of tubular structures....
... Scantibodies Calcitonin Immunoassay is a two-site immunoradiometric ... Two different goat polyclonal antibodies to human ... to be specific for well-defined regions on ... determination of Calcitonin in human serum. ...
Fully automated Chemiluminescence assay for the measurement of calcitonin hormone in serum....
Medicine Products: