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JCI online early table of contents: Jan. 2, 2008
Date:1/2/2008

and tumor suppressor genes, respectively. Because various cancers are associated with the deletion of a particular portion of the genome containing AHRR, scientists believe that a tumor suppressor gene is located in that region. A new study by Enrique Zudaire and his colleagues at the National Cancer Institute, Bethesda, has provided evidence that AHRR has tumor suppressor capabilities in a variety of human cancers.

In the study, AHRR gene expression was found to be decreased in cancerous human tissues from various organs including colon, breast, lung, stomach, cervix, and ovary. Artificial suppression of AHRR gene expression in human lung cancer cells using siRNA technology resulted in enhanced tumor cell proliferation, both in culture and when the cells were transplanted into immunocompromised mice. These AHRR-silenced cells also were protected against a form of cell death known as apoptosis, as well as having enhanced migratory and invasive behavior. Finally, overexpression of AHRR in human lung cancer cells resulted in decreased proliferation. The authors therefore concluded from these data that AHRR is a tumor suppressor gene present in various tissues.

TITLE: The aryl hydrocarbon receptor repressor is a putative tumor suppressor gene in multiple human cancers

AUTHOR CONTACT:
Enrique Zudaire
National Cancer Institute, Bethesda, Maryland, USA.
Phone: (301) 496-8050; Fax: (301) 435-8036; E-mail: zudairee@mail.nih.gov.

View the PDF of this article at: https://www.the-jci.org/article.php?id=30024


BONE BIOLOGY

Softly, softly: Phex gene mutation in mouse bone cells causes rickets

X-linked hypophosphatemia (XLH) is the most common form of inherited rickets, a disease characterized by softening of the bones. It is caused by a mutation in the PHEX gene. Mice with a m
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Journal of Clinical Investigation
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