Navigation Links
JCI online early table of contents: Jan. 2, 2008
Date:1/2/2008

EDITOR'S PICK

Il-22 gene delivers the goods and decreases intestinal inflammation

There are two major types of inflammatory bowel disease (IBD), Crohn disease (CD) and ulcerative colitis (UC). Conflicting reports have indicated that the soluble factor IL-22 can have both IBD promoting and IBD controlling effects. But now, Atsushi Mizoguchi and colleagues at Massachusetts General Hospital, Boston, have established that IL-22 ameliorates disease in a mouse model of UC.

Expression of IL-22 is much higher in the intestines of individuals with CD than UC. To investigate the role of IL-22 in IBD, the authors used a new microinjection-based strategy to deliver the gene that makes IL-22 to the walls of the intestine of mice who suffer from an intestinal disease that models UC. Delivery of the Il-22 gene ameliorated local intestinal inflammation through enhanced mucus production. Consistent with this, when the same strategy was used to deliver a gene that makes a protein that neutralizes IL-22, IL-22binding protein, to the walls of the intestines of normal mice it enhanced chemical-induced intestinal inflammation. The authors therefore suggest that individuals with UC might benefit from local delivery of the IL-22 gene to their intestines.

TITLE: IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis

AUTHOR CONTACT:
Atsushi Mizoguchi
Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Phone: (617) 726-2588; Fax: (617) 726-2365; E-mail: amizoguchi@partners.org.

View the PDF of this article at: https://www.the-jci.org/article.php?id=33194


EDITOR'S PICK

Epilepsy and brain pathology linked together by the protein ADK

The brain of individuals who suffer from epilepsy is characte
'/>"/>

Contact: Karen Honey
press_releases@the-jci.org
215-573-1850
Journal of Clinical Investigation
Source:Eurekalert

Page: 1 2 3 4 5 6 7 8 9

Related medicine news :

1. HIV denialists spread misinformation online -- consequences could be deadly; and more
2. Consequences of online HIV denial; and more
3. Online Epidemic Gives Clues to Bird Flu Spread
4. MedHelp to Add Top Stanford Surgeons and Specialized Forums to Online Health Community
5. Online Celebrity Shoe Charity Auction for Womens Heart Health Opens Bidding
6. Syndicom to Launch Online Community for DePuy Spine
7. Elder Caregiving Site ShirleyBOARD.com Wins WebAward for Outstanding Online Community
8. Peer-Reviewed, Online Database Showcases Local, County and State Pandemic Planning
9. CIGNA Behavioral Health Offers Members Online Provider Profiles
10. Dynamic Energy Systems Goes Online and On-Demand
11. North Shore-LIJ Health System Begins Online Posting of Hospital Infection Rates, Other Performance Information
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/2/2015)... (PRWEB) May 02, 2015 Vancouver fencing company, ... now provide valuable advice to prospective clients related to their ... looking to install railings around their decks and patios. While ... questions that pop up once the person rolls up their ... of installing a railing in finding a gate that matches ...
(Date:5/2/2015)... Beach, FL (PRWEB) May 02, 2015 ... has selected The Delray Recovery Center as one of ... Center is known in the addiction treatment field for ... staff members to innovate and to continue their educational ... a positive workplace environment, never forgetting their purpose – ...
(Date:5/2/2015)... As a nonsurgical staple in the ... neck and décolleté, radiofrequency energy is proving to ... the success of vulvovaginal rejuvenation. In a pilot ... ThermiGyn’s Women’s Health Clinical Advisory Board Chairman Red ... temperature controlled radio frequency, specifically that of ThermiVa, ...
(Date:5/1/2015)... Caicos Islands, BWI (PRWEB) May 02, 2015 ... website! It is http://www.thevenetiangracebay.com , and it ... it incorporates the stunning white and attractive turquoise hues ... study of Google, sixty seven percent of leisure travelers ... study showed that smartphones were used in the planning ...
(Date:5/1/2015)... 2015 The Workgroup for Electronic ... on the use of health IT to create efficiencies ... resource to the United States Government Accountability Office (GAO) ... cards in Medicare. The report, “ Potential Uses of ... released to the public on Apr. 24, 2015 and ...
Breaking Medicine News(10 mins):Health News:Professional Staff at QS Fencing Company Now Provides Advice on Railings and Gates 2Health News:The Delray Recovery Center Named 2015 Top Workplace 2Health News:Study Demonstrates Efficacy of Temperature Controlled Radiofrequency for Vulvovaginal Laxity 2Health News:Study Demonstrates Efficacy of Temperature Controlled Radiofrequency for Vulvovaginal Laxity 3Health News:Turks and Caicos Resort, The Venetian on Grace Bay, Launches New Web Presence 2Health News:WEDI Contributes to Newly Released U.S. Government Accountability Office (GAO) Study on Potential Use of Electronically Readable Medicare Cards 2Health News:WEDI Contributes to Newly Released U.S. Government Accountability Office (GAO) Study on Potential Use of Electronically Readable Medicare Cards 3
... Gerontology: Medical Sciences (Vol. 63, No. 3) features ... geriatric assessment - an interdisciplinary diagnostic process to determine ... frail elderly patients in order to develop a coordinated, ... publication was guest edited by Darryl Wieland, PhD, MPH, ...
... of 221 men and women found that the brains ... showed evidence of small, cumulative blood vessel damage that ... Montine and colleagues analyzed the brain tissue of select ... wherein 3,400 adult participants (65+) in the Seattle region ...
... 2008 Pitt County Memorial,Hospital (PCMH) today ... in the rate of ventilator-associated pneumonia (VAP),due ... surgical,intensive care unit (SICU) with the implementation ... data were presented today as a poster,at ...
... major source of free radicals in cells, mitochondria contribute ... play a role in the pathogenesis of Alzheimers disease. ... Roberta Brinton, University of Southern California, demonstrates that estrogen ... increasing the ability of the mitochondria to generate energy ...
... 4, 2008 Officials,at Old Sturbridge Village report that ... Thursday. In accordance with procedures, the OSV farm staff ... remains were sent,to the Massachusetts state lab for testing. ... rabies., At this time, it does not appear ...
... Man Fight Illness and Enjoy His,Loving Family, ROUND ... was in the process of rebuilding his life after,overcoming ... felt his body stiffen while driving, and a trip ... and a minor stroke from a,blood clot in his ...
Cached Medicine News:Health News:Special journal section explores geriatric assessment 2Health News:Preliminary Data From Pitt County Memorial Hospital Study Show Benefit of Active Surveillance on Reducing MRSA VAP Rates in Surgical ICU 2Health News:Preliminary Data From Pitt County Memorial Hospital Study Show Benefit of Active Surveillance on Reducing MRSA VAP Rates in Surgical ICU 3Health News:Mitochondria play role in pathogenesis of AD and estrogen-induced neuroprotection 2Health News:The SCOOTER Store Donates Power Scooter to an Uninsured Young Father Battling Cancer 2Health News:The SCOOTER Store Donates Power Scooter to an Uninsured Young Father Battling Cancer 3
(Date:4/30/2015)... 30, 2015  Accuray Incorporated (Nasdaq: ARAY ... agreement with MIM Software Inc. to further develop ... and CyberKnife ® product portfolios. The new software ... This is Accuray,s second collaboration with MIM; the ... first iPad-based treatment plan review capability, PlanTouch™. ...
(Date:4/30/2015)... 2015  Thoratec Corporation (NASDAQ: THOR ), a ... support and restore failing hearts, said today it will ... Healthcare Conference on Thursday, May 14. ... will provide an update on the company, beginning at ... Time). The presentation will be available through ...
(Date:4/30/2015)... April 30, 2015  DURECT Corporation (Nasdaq: DRRX ... of 2015.  Total revenues were $4.8 million and net ... March 31, 2015 as compared to total revenues of ... the three months ended March 31, 2014.At March 31, ... compared to cash and investments of $34.9 million at ...
Breaking Medicine Technology:Accuray Signs Agreement with MIM Software Inc. to Develop Adaptive Therapy Software 2Accuray Signs Agreement with MIM Software Inc. to Develop Adaptive Therapy Software 3Thoratec Presentation At Bank Of America Merrill Lynch Healthcare Conference To Be Webcast 2DURECT Corporation Announces First Quarter 2015 Financial Results and Update of Programs 2DURECT Corporation Announces First Quarter 2015 Financial Results and Update of Programs 3DURECT Corporation Announces First Quarter 2015 Financial Results and Update of Programs 4DURECT Corporation Announces First Quarter 2015 Financial Results and Update of Programs 5DURECT Corporation Announces First Quarter 2015 Financial Results and Update of Programs 6DURECT Corporation Announces First Quarter 2015 Financial Results and Update of Programs 7DURECT Corporation Announces First Quarter 2015 Financial Results and Update of Programs 8DURECT Corporation Announces First Quarter 2015 Financial Results and Update of Programs 9
... National Basketball Association (NBA), the Women,s National Basketball Association ... collaboration with the American Diabetes Association and Sanofi US, ... Dribble to Stop Diabetes campaign, a national multimedia ... healthy lifestyle and raise awareness about diabetes prevention, management ...
... Md., Jan. 26, 2012  Vanda Pharmaceuticals Inc. (NASDAQ: ... for the first time to reset the body clock ... in patients suffering from Non-24-Hour Sleep-Wake Disorder (Non-24-Hour Disorder).  ... treatment of Non-24-Hour Disorder in totally blind individuals with ...
Cached Medicine Technology:NBA, American Diabetes Association and Sanofi US Tip Off 2012 Dribble to Stop Diabetes Campaign 2NBA, American Diabetes Association and Sanofi US Tip Off 2012 Dribble to Stop Diabetes Campaign 3NBA, American Diabetes Association and Sanofi US Tip Off 2012 Dribble to Stop Diabetes Campaign 4Initial Clinical Data Reveal Potential of Tasimelteon to Reset the Body Clock in Non-24-Hour Sleep-Wake Disorder 2Initial Clinical Data Reveal Potential of Tasimelteon to Reset the Body Clock in Non-24-Hour Sleep-Wake Disorder 3Initial Clinical Data Reveal Potential of Tasimelteon to Reset the Body Clock in Non-24-Hour Sleep-Wake Disorder 4Initial Clinical Data Reveal Potential of Tasimelteon to Reset the Body Clock in Non-24-Hour Sleep-Wake Disorder 5
This adjustable lid speculum is angled 45 degrees and has 17 mm wire blades. It was designed to aspirate excess fluid around the eye during cataract and refractive procedures....
Angled 45 degrees. Open 13 mm blades. Screw-controlled locking mechanism. Dull finish....
Open blade design with aspiration capabilities for removing fluids from the operative site....
Solid 15 mm blades with 8 mm narrowed portion. Screw-controlled locking mechanism with stabilizing disk. Dull finish....
Medicine Products: