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JCI online early table of contents: Jan. 17, 2012
Date:1/17/2012

p://www.jci.org/articles/view/43937?key=745e8aa8846e5f104b79">http://www.jci.org/articles/view/43937?key=745e8aa8846e5f104b79


NEPHROLOGY: Maintaining integrity in the kidney

A central function of our kidneys is to filter waste from our blood and to divert it into our urine. Specialized cells known as podocytes are key to the integrity of the filtration barrier. Many kidney diseases are characterized by abnormal function of the filtration barrier, which occurs because podocyte morphology (structure) is altered. Such diseases are known as glomerular diseases. A team of researchers led by Lawrence Holzman, at the University of Pennsylvania, Philadelphia, has now identified a molecular pathway involved in the alterations to podocyte morphology observed in mouse models of glomerular disease. They team suggest that inhibitors of molecules in this signaling pathway, for example inhibitors of the FAK-Cas-Crk protein complex, might help prevent the podocyte structural changes associated with glomerular diseases.

TITLE: Crk1/2-dependent signaling is necessary for podocyte foot process spreading in mouse models of glomerular disease

AUTHOR CONTACT:
Lawrence B. Holzman
University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Phone: 215.573.1831; Fax: 215.898.1830; E-mail: lholzman@upenn.edu.

View this article at: http://www.jci.org/articles/view/60070?key=26e460af554f691c1702


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Contact: Karen Honey
press_releases@the-jci.org
734-546-5242
Journal of Clinical Investigation
Source:Eurekalert

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