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JCI online early table of contents: Jan. 17, 2012
Date:1/17/2012

ory environment in liver cancer modifies outcome

Hepatocellular carcinoma (HCC) is the most common form of liver cancer and the third leading cause of cancer-related death worldwide. In most cases, HCC develops after a sustained period of inflammation in the liver, for example as a result of alcoholism or infection with hepatitis C virus. Genetic mutations that activate the signaling molecule beta-catenin are seen in a subset of HCCs, and individuals with these tumors have a better prognosis. A team of researchers, led by Mireille Viguier and Christine Perret, at the Institut Cochin, Paris, has now generated data in mice that provide a potential molecular explanation for this.

Viguier, Perret, and colleagues found that activation of beta-catenin signaling modulates the inflammatory environment to control tumor development. Specifically, beta-catenin signaling was shown to activate both pro- and anti-inflammatory molecules. The resulting inflammatory environment, while permissive for tumor development also contained components that somewhat restrained tumor development and spread to distant sites. Detailed analysis of these restraining components identified potential new targets for immunotherapeutic approaches to treating patients with HCC.

TITLE: Oncogenic beta-catenin triggers an inflammatory response that determines the aggressiveness of hepatocellular carcinoma in mice

AUTHOR CONTACT:
Mireille Viguier
Institut Cochin, INSERM U1016, UMR CNRS 8104, Universit Ren Descartes, Paris, France.
Phone: 33.1.57.27.80.06; Fax: 33.1.57.27.80.87; E-mail: mireille.viguier@inserm.fr.

Christine Perret
Institut Cochin, INSERM U1016, UMR CNRS 8104, Universit Ren Descartes, Paris, France.
Phone: 33.1.44.41.25.64; Fax: 33.1.44.41.24.21; E-mail: christine.perret@inserm.fr.

View this article at:

Contact: Karen Honey
press_releases@the-jci.org
734-546-5242
Journal of Clinical Investigation
Source:Eurekalert

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