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JCI online early table of contents: Jan. 17, 2012
Date:1/17/2012

.263.6729; E-mail: Nina.Bhardwaj@med.nyu.edu.

View this article at: http://www.jci.org/articles/view/61345?key=3f09068264890ed311f8


VIROLOGY: How to prevent hepatitis B virus reproducing

Infection with hepatitis B virus (HBV) is a major health problem worldwide, despite the fact that a highly effective preventative vaccine exists. A modified form of the immune molecule IFN-alpha is commonly used to treat individuals infected with HBV. The rationale behind this is that IFN-alpha inhibits HBV replication in vivo and in vitro, although the mechanisms by which it does this have not been clearly defined. A team of researchers led by Maura Dandri, at University Medical Hospital Hamburg-Eppendorf, Germany; and Massimo Levrero, at Sapienza University, Italy has now identified a new mechanism by which IFN-alpha suppresses HBV replication in vitro and in vivo. The authors hope that this new insight could help in the development of new approaches to treat individuals infected with HBV.

TITLE: IFN-alpha inhibits HBV transcription and replication in cell culture and in humanized mice by targeting the epigenetic regulation of the nuclear cccDNA minichromosome

AUTHOR CONTACT:
Maura Dandri
University Medical Hospital Hamburg-Eppendorf, Hamburg, Germany.
Phone: 49.40.741052949; Fax: 49.40.741057232; E-mail: m.dandri@uke.de.

Massimo Levrero
Sapienza University, Rome, Italy.
Phone: 39.06.49970892; Fax: 39.06.4452388; E-mail: massimo.levrero@uniroma1.it.

View this article at: http://www.jci.org/articles/view/58847?key=3a5c4549350a2300311e


ONCOLOGY: Modulating the inflammat
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Contact: Karen Honey
press_releases@the-jci.org
734-546-5242
Journal of Clinical Investigation
Source:Eurekalert

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