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JCI online early table of contents: Jan. 12, 2009
Date:1/12/2009

EDITOR'S PICK: Opiods provide relief from neuropathic pain

The pain that is associated with injury to nerves, such as caused by the trauma of amputation, entrapment, and compression, is known as neuropathic pain. It can be extremely debilitating, and treatments show limited or no effectiveness. Nerve injury underlying neuropathic pain is associated with an inflammatory response, and immune cells are thought to be contributors to the pain. However, Halina Machelska and colleagues, at Freie Universitt Berlin, Germany, have now shown that in a mouse model of neuropathic pain, a substantial proportion of the immune cells at the site of nerve injury produce chemicals known as opiods that markedly reduce the symptoms of neuropathic pain. The authors therefore suggest that selectively targeting opioid-containing immune cells at sites of nerve injury could provide natural pain relief and offer a novel approach for neuropathic pain.

TITLE: Immune cellderived opioids protect against neuropathic pain in mice

AUTHOR CONTACT:
Halina Machelska
Freie Universitt Berlin, Medizinische Fakultt Charit-Universittsmedizin Berlin, Berlin, Germany.
Phone: 49-30-8445-3851; Fax: 49-30-8445-3826; E-mail: halina.machelska@charite.de.

View the PDF of this article at: https://www.the-jci.org/article.php?id=36246


IMMUNOLOGY: New effect on the immune system of Vitamin D3

A group of proteins known as TLRs recognize molecules produced by microorganisms such as bacteria and viruses and trigger an immune response. Several approaches to targeting one of these proteins, TLR9, are being developed to help boost the efficacy of antitumor immunotherapies and vaccines. Catherine Hawrylowicz and colleagues, at King's College London, United Kingdom, have now provided new insight into how drugs that stim
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Contact: Karen Honey
press_releases@the-jci.org
215-573-1850
Journal of Clinical Investigation
Source:Eurekalert

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