Navigation Links
JCI online early table of contents: Jan. 10 2008
Date:1/10/2008

that mitochondrial defects were present in diabetic, but not pre-diabetic glucose intolerant, mice. The mitochondrial disruptions were subsequently shown to be the result of the generation of reactive oxygen species (ROS), highly reactive molecules implicated in a number of cellular disruptions. Indeed, ROS production coincided with mitochondrial dysfunction, and antioxidant treatment blocked the mitochondrial alterations in muscle cells. The authors therefore concluded that treatment of diabetics with medications that either block ROS production or counteract their deleterious effects might improve the success of conventional therapies.

TITLE: Mitochondrial dysfunction results from oxidative stress in the skeletal muscle of diet-induced insulin-resistant mice

AUTHOR CONTACT:
Jennifer Rieusset
INSERM U870, Facult de Mdecine Lyon Sud, Oullins, France.
Phone: 33-4-26-23-59-20; Fax: 33-4-26-23-59-16; E-mail: jennifer.rieusset@univ-lyon1.fr.

View the PDF of this article at: https://www.the-jci.org/article.php?id=32601


NEPHROLOGY: Claudin 16 and claudin 19 synergize to select what escapes through the kidney

Familial hypomagnesemia with hypercalciuria and nephrocalcinosis (FHHNC) is a genetic disorder that can lead to kidney failure. It is characterized by calcium and magnesium loss by the kidneys, due to mutations in the genes CLN16 and CLN19, which encode the claudin family proteins claudin 16 and claudin 19, respectively. Claudins are important components of cellular tight junctions, areas where two cells meet and form a barrier that is almost impermeable to fluid. Loss of function in tight junctions is believed to be responsible for FHHNC, although the mechanisms underlying the specific roles of claudins 16 and 19 in the process have not been understood. A new study by Daniel Goodenoug
'/>"/>

Contact: Karen Honey
press_releases@the-jci.org
215-573-1850
Journal of Clinical Investigation
Source:Eurekalert

Page: 1 2 3 4 5 6 7 8 9 10 11

Related medicine news :

1. HIV denialists spread misinformation online -- consequences could be deadly; and more
2. Consequences of online HIV denial; and more
3. Online Epidemic Gives Clues to Bird Flu Spread
4. MedHelp to Add Top Stanford Surgeons and Specialized Forums to Online Health Community
5. Online Celebrity Shoe Charity Auction for Womens Heart Health Opens Bidding
6. Syndicom to Launch Online Community for DePuy Spine
7. Elder Caregiving Site ShirleyBOARD.com Wins WebAward for Outstanding Online Community
8. Peer-Reviewed, Online Database Showcases Local, County and State Pandemic Planning
9. CIGNA Behavioral Health Offers Members Online Provider Profiles
10. Dynamic Energy Systems Goes Online and On-Demand
11. North Shore-LIJ Health System Begins Online Posting of Hospital Infection Rates, Other Performance Information
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/22/2014)... 22, 2014 Cumberland Pediatric Dentistry ... dental experience that values anxiety-free dental care for children, ... for a child's dental care. , The orthodontic ... care to infants, adolescents, adults and those with special ... physical disability, or require unique care, such as cleft ...
(Date:7/22/2014)... 2014 NOVAtime Technology, Inc. ( ... and Attendance / Workforce Management solutions, announced today ... customer since 2007, has upgraded to NOVAtime ... state-of-the-art, web-based time and attendance / workforce management ... is a human services agency that provides support ...
(Date:7/22/2014)... Colorado (PRWEB) July 22, 2014 CareTouch ... called CareTouch in the Community . CareTouch employees ... year, and provide hands-on support in line with their ... improve their health. The program’s first cause is Hike ... Hospice. , On Sunday, September 14, the CareTouch ...
(Date:7/22/2014)... (PRWEB) July 22, 2014 The ... Group are now offering robotic assisted laser therapy ... best solutions for men and women suffering from ... procedure they now offer Follicular Unit Extraction (FUE) ... medical robot. With this new technology, their doctors ...
(Date:7/22/2014)... 22, 2014 The physical demands of ... plyometrics, powerlifting, gymnastics, kettleball lifting, calisthenics, and strongman exercises ... Jason Sobzcak, co-owner of CrossFit East Cobb, ... because extreme workouts like these require high quality supplementation. ... I need to take in about 160 grams of ...
Breaking Medicine News(10 mins):Health News:Cumberland Pediatric Dentistry and Orthodontics of Clarksville Welcomes Dr. Peter Wojtkiewicz, Pediatric Orthodontist 2Health News:Cumberland Pediatric Dentistry and Orthodontics of Clarksville Welcomes Dr. Peter Wojtkiewicz, Pediatric Orthodontist 3Health News:Lutheran Services in Iowa Upgrades to NOVAtime 4000 Time and Attendance / Workforce Management Solution; Benefits from Labor Costing Functionality 2Health News:Lutheran Services in Iowa Upgrades to NOVAtime 4000 Time and Attendance / Workforce Management Solution; Benefits from Labor Costing Functionality 3Health News:CareTouch is a Peak Sponsor for the 9th Annual Hike for Hospice in Morrison, Colorado 2Health News:WeGrowHair.com/PAI Medical Group Introduces Robotic Assisted Laser Therapy to Treat Hair Loss 2Health News:CrossFit East Cobb Fuels Their Intense Workouts with All-Natural EnergyFirst Supplements 2Health News:CrossFit East Cobb Fuels Their Intense Workouts with All-Natural EnergyFirst Supplements 3
... to be a major complication of diabetes, despite the ... amputations are currently performed among the diabetic population. ... in the retinas of about 900 diabetic patients who ... All were followed for 20 years to assess how ...
... new study shows hydrotherapy, or water exercise, may improve strength ... Australia studied more than 100 patients with osteoarthritis who were ... The first group exercised three times a week in a ... third did not exercise at all. Both the water and ...
... Chronic lung disease is a primary long-term complication among ... are at greater risk for pulmonary hypertension and impaired ... risk of developing neurological problems. ,A new ... benefit from treatment with inhaled nitric oxide. ,Researchers ...
... pain, pelvic pressure, frequent urination or abnormal periods, uterine ... found in the uterus and can// range in size ... or larger. Now, there’s an improvement to uterine fibroid ... choice for many women. ,Sabrina Figueroa considers herself ...
... back pain is when symptoms have lasted for less ... program that includes group classes, exercise sheet// handouts, and ... their back pain. ,Researchers from Indiana University ... low back pain. The program focuses on boosting confidence ...
... years, Keith Black, M.D., from Cedars-Sinai Medical Center in Los ... cancer. While his research moves forward, he’s helping patients ... tumor vaccine. Dr. Black says brain tumors ... the immune system could use to recognize the tumor. By ...
Cached Medicine News:Health News:Uterine Fibroid Embolization Gaining Popularity 2Health News:New vaccine for brain cancer 2
(Date:7/21/2014)... PLEASANTON, Calif. , July 21, 2014 ... leader in device-based mechanical circulatory support therapies to save, ... will report its operating results for the second quarter ... The company will hold a conference call to ... all interested parties, at 1:30 p.m., Pacific Daylight Time ...
(Date:7/21/2014)... PORTLAND, Oregon , July 21, 2014 /PRNewswire/ ... by Allied Market Research titled, "Global biosimilars/follow-on-biologics market ... Trends, Company Profiles, Demand, Insights, Analysis, Research, Report, ... that the global biosimilars market would reach $35 ... in 2013. Deeper penetration with clearer regulatory pathways ...
(Date:7/21/2014)... By order of the U.S. Bankruptcy Court, Tiger Group,s Remarketing ... optical equipment, designer eyeglass frames, and other assets of ... LLC. Online bidding opens July 21 at ... style, on July 28 beginning at 10:30 a.m. (ET). Previews ... 25 th and 26 th at 12 locations ...
Breaking Medicine Technology:Thoratec Schedules Second Quarter Conference Call, Webcast 2Biosimilars/Follow-on-Biologics Market is Expected to Reach $35 Billion, Globally, by 2020 2Biosimilars/Follow-on-Biologics Market is Expected to Reach $35 Billion, Globally, by 2020 3Biosimilars/Follow-on-Biologics Market is Expected to Reach $35 Billion, Globally, by 2020 4Auction Set For Assets Of National Optical Services Company 2
... Manufacturing - Has Potential to Address Gaps in Global ... World Health Organization Meeting on Evaluation of Pandemic Influenza ... NVAX ) announced favorable results from the second ... its pandemic influenza virus-like particle (VLP) vaccine candidate. ...
... Scientists announced today the,publication of a landmark peer-reviewed ... Stem Cell Journal which outlines the long term ... neural stem cells for the,treatment of Parkinson,s disease. ... FACS, "We have documented the first successful adult,neural ...
Cached Medicine Technology:Novavax Presents Favorable Results from Phase I/IIa Pandemic Influenza Vaccine Program at World Health Organization Conference 2Novavax Presents Favorable Results from Phase I/IIa Pandemic Influenza Vaccine Program at World Health Organization Conference 3Novavax Presents Favorable Results from Phase I/IIa Pandemic Influenza Vaccine Program at World Health Organization Conference 4Novavax Presents Favorable Results from Phase I/IIa Pandemic Influenza Vaccine Program at World Health Organization Conference 5Groundbreaking Paper Publishes Long Term Results of a Successful Phase I Clinical Trial Using Autologous Neural Stem Cells to Treat Parkinson's Disease 2Groundbreaking Paper Publishes Long Term Results of a Successful Phase I Clinical Trial Using Autologous Neural Stem Cells to Treat Parkinson's Disease 3
Compact, bench-top analyser with minimal water volume requirements and easy waste management....
Compact benchtop clinical chemistry system...
... 350 Chemistry System offers easy operation, maintenance, and ... STAT, or back-up to the powerful VITROS 5,1 ... the job done right the first time. Its ... are efficient, dependable, and easy-to-use. The VITROS 350 ...
Meet Galileo, the best reason to move to automation; the best way to upgrade your capabilities....
Medicine Products: