Navigation Links
JCI online early table of contents: Jan. 10 2008
Date:1/10/2008

for bacterial products

In the study, activation of NOD2 by its ligand MDP was shown to protect mice from experimental colitis, a model of CD, by downregulating signaling through many different TLRs, not just TLR2. Further analysis showed that the effects of NOD2 required the downstream signaling molecule IRF4. The authors therefore suggested that MDP activation of NOD2 controls the innate immune response to commensal bacteria in the gut by negatively regulating signaling through multiple TLRs and that the absence of such regulation in individuals with CARD15 mutations leads to increased susceptibility to CD.

TITLE: Muramyl dipeptide activation of nucleotide-binding oligomerization domain 2 protects mice from experimental colitis

AUTHOR CONTACT:
Warren Strober
National Institutes of Health, Bethesda, Maryland, USA.
Phone: (301) 496-6810; Fax: (301) 402-2240; E-mail: wstrober@niaid.nih.gov.

View the PDF of this article at: https://www.the-jci.org/article.php?id=33145


METABOLIC DISEASE: How antioxidant therapy may play a role in the treatment of type 2 diabetes

The incidence of type 2 diabetes in Western society is on the rise, due largely to an increasing prevalence of obesity. Dysfunction of skeletal muscle mitochondria, the powerhouses of a cell, is associated with type 2 diabetes; however, whether this association is causal or consequential has not been understood. A new study by Jennifer Rieusset and her colleagues at INSERM U870, France, has shed light on this question and has provided evidence that alterations in mitochondrial function are the result, and not the cause, of insulin resistance (which usually precedes full-blown clinical type 2 diabetes) in mice.

Mice fed a high-fat, high-sucrose diet (HFHSD) developed insulin resistance and type 2 diabetes. The authors found
'/>"/>

Contact: Karen Honey
press_releases@the-jci.org
215-573-1850
Journal of Clinical Investigation
Source:Eurekalert

Page: 1 2 3 4 5 6 7 8 9 10 11

Related medicine news :

1. HIV denialists spread misinformation online -- consequences could be deadly; and more
2. Consequences of online HIV denial; and more
3. Online Epidemic Gives Clues to Bird Flu Spread
4. MedHelp to Add Top Stanford Surgeons and Specialized Forums to Online Health Community
5. Online Celebrity Shoe Charity Auction for Womens Heart Health Opens Bidding
6. Syndicom to Launch Online Community for DePuy Spine
7. Elder Caregiving Site ShirleyBOARD.com Wins WebAward for Outstanding Online Community
8. Peer-Reviewed, Online Database Showcases Local, County and State Pandemic Planning
9. CIGNA Behavioral Health Offers Members Online Provider Profiles
10. Dynamic Energy Systems Goes Online and On-Demand
11. North Shore-LIJ Health System Begins Online Posting of Hospital Infection Rates, Other Performance Information
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2014)... famous online supplier of trendy clothes, has unveiled its new ... all these mini outfits are offered at discounted rates, up ... September 14. , The company’s senior spokesman states, “To ... designs, we have listed some of the best-selling items in ... to get high quality, fashionable clothes. Many of our sexy ...
(Date:8/29/2014)... (PRWEB) August 29, 2014 DailyGossip.org publishes ... is an absolutely unique method of curing multiple sclerosis ... program was created by Dr. Gary M. Levin, who ... specialist started to become interested in alternative remedies for ... classical remedies cannot be effective in all cases for ...
(Date:8/29/2014)... Champion boxers Laila Ali and Victor Ortiz are ... annual MDA Show of Strength Telethon this Labor Day ... stations across the country. , Ali, former super ... with Laila Ali," will introduce a performance from American ... Association's nationally broadcast show. , Ortiz will introduce R&B ...
(Date:8/29/2014)... According to a CNN article, entitled Medical Marijuana ... study found that those states who legalized medical marijuana ... in the number of painkiller overdoses seen. By reviewing ... comparing various states with and without legalized medical marijuana, ... a 25% decrease in painkiller prescription overdoses in legalized ...
(Date:8/29/2014)... According to new research presented in a Science Daily article ... Drug Misuse Among Young Adults (8/16), peer pressure should ... it comes to prescription drug abuse. Researchers from Purdue University ... problem which influences misuse of prescription drugs is access to ... to have fun with other using friends. Evidently there is ...
Breaking Medicine News(10 mins):Health News:Cheap Sexy Mini Dresses Added To The Product Line Of Skmen.com 2Health News:New Natural Multiple Sclerosis Treatment Review Reveals Gary M. Levin’s Unique Cure 2Health News:Champion Boxers Fight Back Against Muscle Disease 2Health News:Champion Boxers Fight Back Against Muscle Disease 3Health News:Overdoses on Painkillers Decreased in States With Medical Marijuana 2Health News:Overdoses on Painkillers Decreased in States With Medical Marijuana 3Health News:Peer Pressure Irrelevant in Prescription Drug Abuse for Young Adults 2Health News:Peer Pressure Irrelevant in Prescription Drug Abuse for Young Adults 3
... MA Brandeis psychologist Margie E. Lachman has been awarded ... on Aging to learn more about factors that can ... research will identify modifiable beliefs and behaviors that are ... life. , Many middle-aged and older adults believe that ...
... Lives of Eight Families Living with Autism, NEW ... television premiere of Lauren Thierry,s documentary Autism Every Day,on ... Awareness Day by,the United Nations. The film, which debuted ... day in the lives of eight families,struggling to raise ...
... editors of the Proceedings of the National Academy of ... the 2007 Cozzarelli Prize, an award for papers that ... , The award was established in 2005 as the ... Cozzarelli Prize in 2007 to honor late PNAS Editor-in-Chief ...
... 13 Leading speech,pathologist and autism consultant Valerie ... needs technologies at the "Autism Through,the Lifespan" conference ... "The future is now for an entire generation ... of their lives and becoming young,adults with autism. ...
... Inc. (Pink Sheets: HCFE) has established HEALTHY COFFEE ... distribution of Healthy Coffee,drinks and wellness products through ... About Healthy Coffee USA, Inc., HEALTHY COFFEE ... Coffee by providing an opportunity for the average ...
... With Erectile Dysfunction Are Smokers, NEW YORK, Feb. ... attractiveness, it does the exact opposite when he reaches,the ... recent studies, 60-percent of all men who smoke suffer,from ... more passion. In an effort to dramatically improve upon ...
Cached Medicine News:Health News:Brandeis researcher awarded grant to investigate memory and aging 2Health News:Sundance Channel to Premiere Documentary Autism Every Day on World Autism Awareness Day, April 2nd at 8:00pm et/pt 2Health News:PNAS announces 2007 Cozzarelli Prize recipients 2Health News:A Sneak Peek Into the Special Needs Home of Tomorrow - Renowned Autism Consultant Valerie Herskowitz to Present Latest Findings at 'Autism Through the Lifespan' Conference February 14-17 in Orlando 2Health News:Healthy Coffee International, Inc. Establishes Healthy Coffee USA, Inc. as Its Marketing Arm 2Health News:The Best Way to Stoke Your Valentine's Fire: Don't Light Up 2
(Date:8/29/2014)... Md. , Aug. 29, 2014  United Therapeutics ... the U.S. District Court for the District of ... favor in the company,s case against Sandoz, Inc. regarding ... Peter Sheridan ruled that U.S. Patent No. ... and enjoined Sandoz from marketing its generic product until ...
(Date:8/29/2014)... , Aug. 29, 2014 Diseases largely ... a generation ago are returning. Measles was declared eliminated ... in 2014 as of August 15—the highest incidence in ... public health department declared whooping cough a problem of ... are getting sick and dying from these preventable diseases—in ...
(Date:8/29/2014)... Research and Markets has announced the addition ... report to their offering. Multiple ... in demyelination, axonal transection, and neurodegeneration. The myelin sheath ... immune system, which targets neurons within the central nervous ... which the damage of the myelin sheath causes disruption ...
Breaking Medicine Technology:District Court Decision Received In Remodulin Patent Case 2Vaccines at the Crossroads: Outbreaks On the Rise Across America 2Vaccines at the Crossroads: Outbreaks On the Rise Across America 3Global Multiple Sclerosis Drugs Market 2014-2018: Key Vendors are Bayer, Biogen Idec, Merck Serono, Novartis and Teva Pharmaceutical 2Global Multiple Sclerosis Drugs Market 2014-2018: Key Vendors are Bayer, Biogen Idec, Merck Serono, Novartis and Teva Pharmaceutical 3
... its wide orifice tip, the Finntip Wide ... suspensions and macromolecules like genomic DNA. This ... cell fragmentation. It is excellent for use ... model, the inside diameter of the orifice ...
300 L, Racked, 96 tips/rack Recommended for 250 and 300 L pipettes....
... Application: Pipette tips in a ... Product features of Autoclavable Racks: ... C, Tips supplied in racks with ... Each row of tips is specifically ...
RNase-free Tips...
Medicine Products: