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JCI online early table of contents: Jan. 10 2008
Date:1/10/2008

levels of CO2 in arterial blood are associated with poor outcome. New data generated in rats, by Jacob Sznajder and colleagues at Northwestern University, Feinberg School of Medicine, Chicago, have provided new insight into the mechanisms by which elevated levels of CO2 in the blood impair the function of the cells lining the lungs (alveolar epithelial cells [AECs]) increased levels of CO2 in the blood induced an increase in Ca2+ concentration and CaMKK-beta activity inside AECs, leading to rapid activation of the protein AMPK. This, in turn, caused activation of PKC-theta and thereby decreased the abundance of the protein Na,K-ATPase at the surface of AECs, impairing the ability of these cells to remove fluid from the lungs and resulting in difficulty breathing.

AUTHOR CONTACT:
Jacob I. Sznajder
Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA.
Phone: (312) 908-7737; Fax: (312) 908-4650; E-mail: j-sznajder@northwestern.edu.

Marla Paul
Northwestern University, Chicago, Illinois, USA.
Phone: (312) 503-8928; E-mail: marla-paul@northwestern.edu

View the PDF of this article at: https://www.the-jci.org/article.php?id=29723


IMMUNOLOGY: Pathogens have a say in the identity of the immune cells recruited to the site of infection

New data, generated by Deborah Fowell and Shoshana Katzman from the University of Rochester, has indicated that in a mouse model of infection of the connective tissues underlying the skin (the dermis) the pathogen at the infection site can modulate the type of pathogen-aggressive immune cell known as an effector T cell that accumulates.

In the study, it was observed that at the site of dermal infection with the parasite Leishmania major, soluble molecules (known as chemokines) that attra
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Contact: Karen Honey
press_releases@the-jci.org
215-573-1850
Journal of Clinical Investigation
Source:Eurekalert

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