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JCI online early table of contents: Feb. 8, 2010
Date:2/8/2010

estinal polyps and colonic tumors compared with parental ApcMin/+ mice. Similar results were obtained in a second mouse model of colorectal adenocarcinoma, providing further confirmation of the probable tumor suppressor role of Rab25 in intestinal epithelial cells.

TITLE: Loss of Rab25 promotes the development of intestinal neoplasia in mice and is associated with human colorectal adenocarcinomas

AUTHOR CONTACT:
James R. Goldenring
Vanderbilt University School of Medicine, Nashville, TN, USA.
Phone: 615.936.3726; Fax: 615.343.1591; Email: jim.goldenring@vanderbilt.edu.

View this article at: http://www.jci.org/articles/view/40728?key=23ce364555ecb5bda924


IMMUNOLOGY: Complete chemokine profile of a cell

Chemokines are a large group of proteins whose predominant function is to direct cell migration. They regulate many physiological and pathophysiological processes, in particular in the immune system. Dirk Homann and colleagues, at University of Colorado Denver, Aurora, have now developed a simple method to efficiently identify all the chemokines produced by a single cell type, something that has not been possible before.

The method developed by Homann and colleagues is a flow cytometrybased assay that uses commercially available chemokine-specific antibodies to efficiently detect within cells 37 of 39 mouse chemokines. Using this technique, the author were able to delineate the complete chemokine profiles of two types of immune cell (NK cells and B cells) in response to major polyclonal stimuli and to assess the chemokine response of immune cells known as DCs to bacterial infection. Importantly, the authors were able to adapt the method to analyze chemokine expression in human cells, leading them to suggest that this method will help researchers underst
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Contact: Karen Honey
press_releases@the-jci.org
215-573-1850
Journal of Clinical Investigation
Source:Eurekalert

Page: 1 2 3 4 5 6

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