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JCI online early table of contents: Feb. 7, 2011
Date:2/7/2011

fluid and bicarbonate (HCO3) secretion from the body. Such secretion occurs in organs such as the kidney and pancreas as well as the gastrointestinal tract. It is regulated by the epithelial cells that line the secretion ducts. Numerous diseases, including cystic fibrosis, involve aberrant epithelial cell regulation of fluid and bicarbonate secretion. A team of researchers, led by Shmuel Muallem, at the National Institutes of Health, Bethesda, has now provided new insight into the molecular mechanisms that control pancreatic ductal secretion of fluid and bicarbonate in mice. Specifically, the team found that WNK proteins act through the protein SPAK to suppress ductal fluid secretion, whereas the proteins IRBIT and PP1 promote ductal fluid secretion and reverse the effect of the WNKs and SPAK. These data have implications for understanding conditions associated with aberrant epithelial cell regulation of fluid and bicarbonate secretion, including cystic fibrosis and high blood pressure.

TITLE: IRBIT governs epithelial secretion in mice by antagonizing the WNK/SPAK kinase pathway

AUTHOR CONTACT:
Shmuel Muallem
National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA.
Phone: 301.402.0262; Fax: 301.402.1228; E-mail: shmuel.muallem@nih.gov.

View this article at: http://www.jci.org/articles/view/43475?key=f181ef655be6a828e695


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Contact: Ushma Neill
press_releases@the-jci.org
734-546-5241
Journal of Clinical Investigation
Source:Eurekalert

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