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JCI online early table of contents: Feb. 7, 2011
Date:2/7/2011

p>TITLE: Subunit 6 of the COP9 signalosome promotes tumorigenesis in mice through stabilization of MDM2 and is upregulated in human cancers

AUTHOR CONTACT:
Mong-Hong Lee
University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA.
Phone: 713.794.1323; Fax: 713.792.6059; E-mail: mhlee@mdanderson.org.

View this article at: http://www.jci.org/articles/view/44111?key=b92d917d33543e347de7


STEM CELLS: Stem cells from different sources are not equivalent

Stem cells are considered by many to be promising candidate sources of cells that can be used as therapies to regenerate and repair diseased tissues. There are currently two types of stem cell considered in this context: human embryonic stem cells (hESCs), which are derived from early embryos, and human induced pluripotent stem cells (hiPSCs), which are derived by reprogramming cells of the body such that they have the ability to generate any cell type. Although hESCs and hiPSCs seem to behave in a functionally similar manner, whether they are equivalent at the single cell level has not been determined. To address this issue, a team of researchers, led by Joseph Wu, at Stanford University School of Medicine, Stanford, used single cell analysis to resolve the gene expression profiles of 362 hiPSCs and hESCs. The team found that hiPSCs exhibited substantially more heterogeneity in gene expression than did hESCs, leading them to suggest that hiPSCs have a less stable pluripotent state than hESCs, information that is important to consider when thinking about using these cells for the purpose of regenerative medicine.

TITLE: Single cell transcriptional profiling reveals heterogeneity of human induced pluripotent stem cells

AUTHOR CONTACT: Joseph C. Wu Stanford University School of Medicine, Stanford, Californi
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Contact: Ushma Neill
press_releases@the-jci.org
734-546-5241
Journal of Clinical Investigation
Source:Eurekalert

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