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JCI online early table of contents: Feb. 7, 2011
Date:2/7/2011

trolled activation of immune/inflammatory cells known as macrophages. A team of researchers, led by Karin Scharffetter-Kochanek, at the University of Ulm, Germany, has now defined a specific macrophage population that exists in an unrestrained proinflammatory state in human subjects with chronic venous leg ulcers and a newly established mouse model of the main aspects of the condition. The team therefore suggests that this macrophage population, which is induced by iron, could be targeted to treat chronic inflammatory diseases such as chronic venous leg ulcers.

TITLE: An unrestrained proinflammatory M1 macrophage population induced by iron impairs wound healing in humans and mice

AUTHOR CONTACT:
Karin Scharffetter-Kochanek
University of Ulm, Ulm, Germany.
Phone: 49.731.500.57501; Fax: 49.731.500.57502; E-mail: karin.scharffetter-kochanek@uniklinik-ulm.de.

View this article at: http://www.jci.org/articles/view/44490?key=7b9a8f67d56ff75331db


VIROLOGY: Depletion of immune cells not a correlate of simian AIDS

Progression to AIDS in individuals infected with HIV has classically been associated with loss of immune cells known as CD4+ T cells. However, recent data have indicated that this might not be the best predictor of disease progression. A team of researchers, led by Donald Sodora, at Seattle Biomedical Research Institute, Seattle, has now provided further support for this position by studying SIV (the primate equivalent of HIV) infection of the natural host species sooty mangabeys, which results in high viral replication without clinical signs of simian AIDS. Specifically, they found that acute, SIV-induced CD4+ T cell depletion in sooty mangabeys does not result in immune dysfunction and progression to simian AIDS and that this is because a pop
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Contact: Ushma Neill
press_releases@the-jci.org
734-546-5241
Journal of Clinical Investigation
Source:Eurekalert

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