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JCI online early table of contents: Feb. 7, 2008
Date:2/7/2008

ntenance of blood pressure.

TITLE: A single nucleotide mutation in the mouse renin promoter disrupts blood pressure regulation

AUTHOR CONTACT:
Keiji Tanimoto
University of Tsukuba, Tsukuba, Ibaraki, Japan.
Phone: 81-29-853-6070; Fax: 81-29-853-6070; E-mail: keiji@tara.tsukuba.ac.jp.

View the PDF of this article at: https://www.the-jci.org/article.php?id=33824


ENDOCRINOLOGY: Oxygen deprivation makes the molecule D3 act locally to reduce thyroid hormone levels

The thyroid organ generates hormones that regulate a variety of functions in the body, including energy expenditure. The molecule D3 can inactivate thyroid hormones; however, D3 is typically found in only a few postnatal tissues, although its expression is reactivated in the liver and skeletal muscle of critically ill patients. In a new study, Stephen Huang and his colleagues at the Harvard Institutes of Medicine, Boston, have reported that a state of hypoxia (that is, low oxygen levels) can induce expression of D3 and lead to local inactivation of the thyroid hormone T3.

D3 production was induced following exposure of cultured cells from various species and organs to either hypoxic conditions or chemicals that altered the cellular chemistry to mimic hypoxia. Mechanistically, expression of the gene responsible for the generation of D3 protein was found to be regulated by a protein known as HIF-1. Functionally, inhibition of D3 activity in cultured cells resulted in increased energy expenditure. Finally, the clinical relevance of these data was highlighted by the observation that in a rat model of hypertrophic heart failure a disease that is associated with hypoxia in the heart muscle D3 was induced at the site of hypoxia, causing a localized reduction in T3 levels.

TITLE: Hypoxia-inducible factor induces local thy
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Contact: Karen Honey
press_releases@the-jci.org
215-573-1850
Journal of Clinical Investigation
Source:Eurekalert

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