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JCI online early table of contents: Feb. 7, 2008
Date:2/7/2008

t cultures of human colonic mucosa led to increased expression of pro-inflammatory factors such as IFN-gamma, which was shown to cause damage to the colonic mucosa. The upregulation of IFN-gamma expression was eliminated if the bacterial product LPS was removed from the explant cultures. As IFN-gamma expression could be restored by the addition of a bacterium that lives naturally in the human colon, the authors suggested that IL-10 has a crucial role in maintaining the integrity of the human colonic mucosa.

TITLE: Mucosal IL-10 and TGF-beta play crucial roles in preventing LPS-driven, IFN-gammamediated epithelial damage in human colon explants

AUTHOR CONTACT:
Anne Jarry
INSERM U539, Nantes, France.
Phone: 33-2-40-41-28-30: 33-2-40-41-28-37; E-mail: ajarry@univ-nantes.fr.

View the PDF of this article at: https://www.the-jci.org/article.php?id=32140


NEPHROLOGY: The CNRE region of the renin gene cant handle the blood pressure

The kidney protein renin has a crucial role in maintaining blood pressure. Transcription of the renin gene involves the decoding of its gene sequence to generate the protein. Keiji Tanomoto and colleagues at the University of Tsukuba, Japan, investigated the role of two portions of the renin gene known as RP-2 and CNRE in transcription of the renin gene and regulation of blood pressure. It was found that RP-2, but not CNRE, was essential for transcription of the renin gene and thereby expression of the renin protein in the kidneys of mice. Furthermore, the low blood pressure of renin-deficient mice was not restored to normal by a renin gene lacking the RP-2 region, but it was restored to normal by a renin gene lacking the CNRE region. The authors therefore concluded that RP-2, but not CNRE, is vital for the regulation of transcription of the renin gene and thereby the mai
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Contact: Karen Honey
press_releases@the-jci.org
215-573-1850
Journal of Clinical Investigation
Source:Eurekalert

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