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JCI online early table of contents: Feb. 7, 2008
Date:2/7/2008

o activate mouse iNKT cells for longer periods of time and to target them to tumors.

In the study, mice were given a series of injections of alpha-GalCer bound to a soluble form of a protein known as CD1d (alpha-GalCer/sCD1d). This led to sustained iNKT cell activation as well as activation of other immune cell types important for antitumor immunity NK cells and DCs. Furthermore, when a form of the alpha-GalCer/sCD1d fused to a molecule (known as a scFv antibody fragment) that targeted the protein HER2 was administered to mice injected with tumor cells expressing HER2 two days earlier, the growth and metastasis of the tumor cells was inhibited. This antitumor activity was associated with the accumulation of iNKT cells, NK cells, and DCs at the site of the tumor. The authors therefore suggested that targeting iNKT cells to tumors could provide a new approach to treating many forms of cancer.

TITLE: Sustained activation and tumor targeting of NKT cells using a CD1danti-HER2scFv fusion protein induces antitumor effects in mice

AUTHOR CONTACT:
Alena Donda
University of Lausanne, Epalinges, Switzerland.
Phone: 41-21-692-5737; Fax: 41-21-692-5705; E-mail: alena.donda@unil.ch.

View the PDF of this article at: https://www.the-jci.org/article.php?id=33249


ONCOLOGY: Antitumor immune responses are boosted by TLR9-activated pDCs

The immune response mounted toward tumors is often very weak when compared with that mounted against invading viruses. It has been suggested that this difference is because the tumor microenvironment does not provide signals that activate immune cells known as pDCs through their Toll-like receptors (TLRs). Consistent with this, Patrick Hwu and colleagues were able to induce a potent tumor-specific CD8+ T cell immune response in mice bearing two tumors by injecting TLR9-act
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Contact: Karen Honey
press_releases@the-jci.org
215-573-1850
Journal of Clinical Investigation
Source:Eurekalert

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