Navigation Links
JCI online early table of contents: Feb. 7, 2008
Date:2/7/2008

o activate mouse iNKT cells for longer periods of time and to target them to tumors.

In the study, mice were given a series of injections of alpha-GalCer bound to a soluble form of a protein known as CD1d (alpha-GalCer/sCD1d). This led to sustained iNKT cell activation as well as activation of other immune cell types important for antitumor immunity NK cells and DCs. Furthermore, when a form of the alpha-GalCer/sCD1d fused to a molecule (known as a scFv antibody fragment) that targeted the protein HER2 was administered to mice injected with tumor cells expressing HER2 two days earlier, the growth and metastasis of the tumor cells was inhibited. This antitumor activity was associated with the accumulation of iNKT cells, NK cells, and DCs at the site of the tumor. The authors therefore suggested that targeting iNKT cells to tumors could provide a new approach to treating many forms of cancer.

TITLE: Sustained activation and tumor targeting of NKT cells using a CD1danti-HER2scFv fusion protein induces antitumor effects in mice

AUTHOR CONTACT:
Alena Donda
University of Lausanne, Epalinges, Switzerland.
Phone: 41-21-692-5737; Fax: 41-21-692-5705; E-mail: alena.donda@unil.ch.

View the PDF of this article at: https://www.the-jci.org/article.php?id=33249


ONCOLOGY: Antitumor immune responses are boosted by TLR9-activated pDCs

The immune response mounted toward tumors is often very weak when compared with that mounted against invading viruses. It has been suggested that this difference is because the tumor microenvironment does not provide signals that activate immune cells known as pDCs through their Toll-like receptors (TLRs). Consistent with this, Patrick Hwu and colleagues were able to induce a potent tumor-specific CD8+ T cell immune response in mice bearing two tumors by injecting TLR9-act
'/>"/>

Contact: Karen Honey
press_releases@the-jci.org
215-573-1850
Journal of Clinical Investigation
Source:Eurekalert

Page: 1 2 3 4 5 6 7 8

Related medicine news :

1. HIV denialists spread misinformation online -- consequences could be deadly; and more
2. Consequences of online HIV denial; and more
3. Online Epidemic Gives Clues to Bird Flu Spread
4. MedHelp to Add Top Stanford Surgeons and Specialized Forums to Online Health Community
5. Online Celebrity Shoe Charity Auction for Womens Heart Health Opens Bidding
6. Syndicom to Launch Online Community for DePuy Spine
7. Elder Caregiving Site ShirleyBOARD.com Wins WebAward for Outstanding Online Community
8. Peer-Reviewed, Online Database Showcases Local, County and State Pandemic Planning
9. CIGNA Behavioral Health Offers Members Online Provider Profiles
10. Dynamic Energy Systems Goes Online and On-Demand
11. North Shore-LIJ Health System Begins Online Posting of Hospital Infection Rates, Other Performance Information
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/27/2015)... March 27, 2015 According to a ... ), the plate and screw market in Europe is ... generic plate and screw segment. Price decreases are being ... representing almost 50% of the total European trauma device ... the total market value, year after year. , ...
(Date:3/27/2015)... San Francisco, CA (PRWEB) March 27, 2015 ... Day) Recovery Yoga for functional fitness athletes. This new ... creates a specific protocol for post-workout cool down. This ... mobility, promote breath control and mental focus. , ... said: “I started practicing yoga long before I started ...
(Date:3/27/2015)... Naples, FL and London, UK (PRWEB) March 27, 2015 ... solution, announced today that it has appointed Sean Fitzgerald, ... the role of Chief Operating Officer and Interim Chief ... Vice President of leading education technology innovator, EverFi, backed ... Eric Schmidt, and Twitter founder Evan Williams. Prior to ...
(Date:3/27/2015)... California’s ongoing worst ever drought, and the ... United States Northeast, are both manifestations of the same ... creating changes in the atmosphere’s “energy balance,” according to ... researcher, speaking on the Sharon Kleyne Hour™ Power of ... warmer and dryer global climate but also greater and ...
(Date:3/27/2015)... Trail mix is the perfect, healthy snack for ... and during the game! It’s portable, lightweight and provides a ... introduce a new line of specialty trail mixes that satisfy ... selections packed with nutritious, 100% all natural ingredients. , These ... add protein and fiber to your diet and boost energy. ...
Breaking Medicine News(10 mins):Health News:Titanium Trauma Treatment Devices in Europe Becoming More Affordable, Decreasing Market Value: Group Purchasing Further Eroding Selling Prices 2Health News:Titanium Trauma Treatment Devices in Europe Becoming More Affordable, Decreasing Market Value: Group Purchasing Further Eroding Selling Prices 3Health News:Endure Yoga Introduces WOD Recovery Yoga 2Health News:GenSight Appoints Former Technology Executive as Chief Operating Officer 2Health News:California Drought, Boston Blizzards Both Attributed to Global Climate Change Reports Climatologist to Fresh Water Advocate 2Health News:California Drought, Boston Blizzards Both Attributed to Global Climate Change Reports Climatologist to Fresh Water Advocate 3Health News:Aurora Product, Inc. Introduces New Line of Specialty Trail Mixes 2
... developments bring social and economic benefits to the ... to predict and manage. With rapid advances in ... are increasingly exposed to EMFs at an earlier ... and exposure to extremely low frequency (ELF) magnetic ...
... United Kingdom Trade and Investment’s (UKTI) is looking for ... Confederation of Indian Industry, CII had meetings with UKTI ... Health care providers. , ,David Hawkins of UKTI ... as Apollo Hospitals, KG Hospital and Trivitron Medical systems ...
... and health is well recognized, however, it is frequently ... dietary component and a specific health endpoint. This is ... most of them reach humans through the food chain. ... the occurrence of various chemical contaminants of notable concern ...
... Polytechnique Federale de Lausanne) and the CHUV (Lausanne University ... follicle belong to the true multipotent stem cell category ... for hair growth and follicle replacement. , ,The ... online publication of the October 3 issue of Proceedings ...
... disease is an irreversible neurodegenerative disorder with no known ... was known at that time, we have come a ... disease is characterized by symptoms of memory loss, confusion, ... skills. , ,Mild cognitive impairment (MCI) is a ...
... World Health Organization (WHO), shows that 36 million deaths occurs ... stroke, cancer and diabetes and serious measures has to be ... The main factors which are responsible for the cause of ... eating more food rich in fats and sugars, doing less ...
Cached Medicine News:Health News:Hazards of Electromagnetic Fields for children 2Health News:Athletes Are More Prone To Environmental Pollutants Due To Choice Of Diet 2Health News:PET Scanning can help in early detection of Alzheimer’s diseas 2
(Date:3/27/2015)... March 27, 2015 BioCorRx, Inc. ( ... Ana, California is a healthcare solutions organization, which ... estimated at $22 billion in the U.S. alone. The Company ... FDA-approved Naltrexone in a specially compounded form for outpatient surgical ... and New Zealand ) to ...
(Date:3/27/2015)... 2015 Across the global healthcare landscape, the ... clinical development, market education, and regulatory compliance. As emerging ... function is expected to increase in prominence and follow ... According to research by benchmarking firm, Best Practices, LLC, ... to Medical Affairs. Among companies in India ...
(Date:3/27/2015)...  The quality function within the medical device sector ... standards at every stage of the product life cycle. ... have the challenge of balancing quality and safety with ... effectively balance these priorities risk funding and staffing for ... regulatory scrutiny. For the third consecutive year, ...
Breaking Medicine Technology:Small Cap IR Correction -- BioCorRx Inc. Positions Itself Through Strategic Partnerships To Gain Market Share Of The $22 Billion Substance Abuse Treatment Market In The U.S. 2Medical Affairs Capabilities Expanding in Emerging Marketplaces 2New Medical Device Quality Study Finds Regulatory Environment is Boosting Quality Spending, Especially for Large Companies 2
Supplied sterile in peel-open packages. Intended for one-time use....
... and exchange in endourological procedures. The increased ... allows utilization of an extra heavy duty ... very flexible tip. The proximal end of ... coiled wire guide manufactured by Cook®. Supplied ...
Supplied sterile in peel-open packages. Intended for one-time use....
Supplied sterile in peel-open packages. Intended for one-time use....
Medicine Products: