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JCI online early table of contents: Feb. 16, 2009
Date:2/16/2009

lecules on the nerve cell surface. If the cells were treated to remove the blocking ganglioside molecules the antibodies bound GM1 and damaged the live mouse nerve cells. Similar hidden binding sites on GM1 were identified for human GM1-specific antibodies providing a potential explanation as to why the ability of GM1-specific antibodies to cause neuropathy has been so hotly debated.

TITLE: The neuropathic potential of anti-GM1 autoantibodies is regulated by the local glycolipid environment in mice

AUTHOR CONTACT:
Hugh J. Willison
University of Glasgow, Glasgow, United Kingdom.
Phone: 44-141-330-8384; Fax: 44-141-201-2993; E-mail: h.j.willison@clinmed.gla.ac.uk.

View the PDF of this article at: https://www.the-jci.org/article.php?id=37338


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Contact: Karen Honey
press_releases@the-jci.org
215-573-1850
Journal of Clinical Investigation
Source:Eurekalert

Page: 1 2 3 4

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