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JCI online early table of contents: Feb. 16, 2009
Date:2/16/2009

induced by the drug forskolin. By contrast, in the absence of the protein NHERF2, forskolin-stimulated secretion of HCO3 was enhanced, and in the absence of the protein PDZK1, basal levels of secretion of HCO3 were reduced but forskolin-stimulated secretion was normal. The authors therefore conclude that the three proteins differentially modulate CFTR-dependent secretion of HCO3 in the small intestine and suggest that therapeutically targeting these proteins might provide an effective way to modulate CFTR function.

TITLE: Differential roles of NHERF1, NHERF2, and PDZK1 in regulating CFTR-mediated intestinal anion secretion in mice

AUTHOR CONTACT:
Ursula Seidler
Hannover Medical School, Hannover, Germany.
Phone: 49-0-511-532-9427; Fax: 49-0-511-532-8428; E-mail: seidler.ursula@mh-hannover.de.

View the PDF of this article at: https://www.the-jci.org/article.php?id=35541


NEUROBIOLOGY: Antibodies hidden potential to damage nerves unmasked

Damage to nerves in the tissues, a medical condition known as neuropathy, can cause extremely debilitating pain. In some individuals, nerve damage is associated with the presence of specific immune factors: antibodies that recognize molecules known as GM1 gangliosides. Whether these antibodies actually cause disease has been hotly debated. However, Hugh J. Willison and colleagues, at the University of Glasgow, United Kingdom, have now shown that both mouse and human GM1-specific antibodies can damage live mouse nerve cells.

In the study, initial analysis indicated that only some mouse GM1-specific antibodies could bind and damage live mouse nerve cells. However, further experiments revealed that the other antibodies were unable to bind and damage liver mouse cells because the part of GM1 to which they bind was blocked by other ganglioside mo
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Contact: Karen Honey
press_releases@the-jci.org
215-573-1850
Journal of Clinical Investigation
Source:Eurekalert

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