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JCI online early table of contents: Feb. 15, 2010
Date:2/15/2010

ice lacking the protein PTP1B only in POMC neurons (POMC-Ptp1b/ mice) had decreased fat content and expended more energy than normal mice. By contrast, mice lacking the protein SHP2 only in POMC neurons (POMC-Shp2/ mice) had increased fat content and expended less energy than normal mice. Underlying these data was the fact that POMC-Ptp1b/ mice were able to control glucose levels in their blood easily, whereas POMC-Shp2/ mice were not. These data indicate that PTP1B and SHP2 have reciprocal roles in POMC-neuron regulation of energy balance, at least in mice.

TITLE: PTP1B and SHP2 in POMC neurons reciprocally regulate energy balance in mice

AUTHOR CONTACT:

Kendra K. Bence
University of Pennsylvania, Philadelphia, PA, USA.
Phone: 215.746.2998; Fax: 215.573.5186; E-mail: kbence@vet.upenn.edu.

View this article at: http://www.jci.org/articles/view/39620?key=165b87c2feba4a3c8de1


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Contact: Karen Honey
press_releases@the-jci.org
215-573-1850
Journal of Clinical Investigation
Source:Eurekalert

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