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JCI online early table of contents: Feb. 15, 2010
Date:2/15/2010

that the individual carries.

TITLE: Organotypic specificity of key RET adaptor-docking sites in the pathogenesis of neurocristopathies and renal malformations in mice

AUTHOR CONTACT:

Sanjay Jain
Washington University School of Medicine, St. Louis, MO, USA.
Phone: 314.454.8728; Fax: 314.454.7735; E-mail: sjain22@wustl.edu.

View this article at: http://www.jci.org/articles/view/41619?key=badb101cbe87ee404e42

VASCULAR BIOLOGY: Inflammation contributes to blood vessel disease in neurofibromatosis type 1

Neurofibromatosis type 1 (NF1) is an inherited tumor disorder caused by mutations in the NF1 gene. Individuals with NF1 have any one of a number of clinical symptoms, including learning difficulties, eye problems, and epilepsy. They also often develop blood vessel disease that can result in blood vessels becoming blocked, although how this symptom of NF1 develops has not been determined. But now, by studying mice that model NF1 and humans with NF1, David Ingram Jr and colleagues, at Indiana University School of Medicine, Indianapolis, have generated genetic and cellular evidence that chronic inflammation contributes to the development of blood vessel disease in patients with NF1. The authors therefore suggest that future studies should focus on harnessing this information to develop potential new avenues for therapeutic and diagnostic purposes.

TITLE: Genetic and cellular evidence of vascular inflammation in neurofibromin-deficient mice and humans

AUTHOR CONTACT:

David A. Ingram Jr.
Indiana University School of Medicine, Indianapolis, IN, USA.
Phone: 317.278.8245; Fax: 317.274.8679; E-mail: http://www.jci.o
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Contact: Karen Honey
press_releases@the-jci.org
215-573-1850
Journal of Clinical Investigation
Source:Eurekalert

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