Navigation Links
JCI online early table of contents: Feb. 15, 2010
Date:2/15/2010

itro analysis of human neuroblastoma cell lines indicated that both decreasing NT-3 expression and culturing in the presence of an antibody that blocked NT-3 binding to TrkC triggered the cells to undergo apoptosis. More importantly, blocking the NT-3/TrkC interaction inhibited tumor growth and metastasis in both a chick and a mouse xenograft model of neuroblastoma. The authors therefore suggest that disrupting the NT-3/TrkC interaction might provide a new approach to treating neuroblastoma, a form of cancer for which treatment options are currently limited.

TITLE: Neurotrophin-3 production promotes human neuroblastoma cell survival by inhibiting TrkC-induced apoptosis

AUTHOR CONTACT:

Patrick Mehlen
CNRS UMR5238, Universit de Lyon, Lyon, France.
Phone: 33.4.78.78.28.70; Fax: 33.4.78.78.28.87; E-mail: mehlen@lyon.fnclcc.fr.

View this article at: http://www.jci.org/articles/view/41013?key=7f26b0d679e4415a781a

DEVELOPMENT: Deciphering the role of the protein RET in development

Several diseases and developmental defects, including Hirschsprung disease and congenital anomalies of kidneys or urinary tract (CAKUT) syndrome, are caused by mutations in the RET gene. It is not clear, however, how RET gene mutations lead to such a range of diseases, which can occur in isolation or combination. Insight into this issue has now been provided by Sanjay Jain and colleagues, at Washington University School of Medicine, St. Louis, through their analysis of ten strains of RET mutant mice. Specifically, it was determined that different RET-stimulated signaling pathways control the development of the genitourinary system and the enteric and autonomic nervous systems. This conclusion suggests that an individual's disease symptoms are determined by which signaling pathways are disrupted by the RET gene mutation
'/>"/>

Contact: Karen Honey
press_releases@the-jci.org
215-573-1850
Journal of Clinical Investigation
Source:Eurekalert

Page: 1 2 3 4 5 6

Related medicine news :

1. HIV denialists spread misinformation online -- consequences could be deadly; and more
2. Consequences of online HIV denial; and more
3. Online Epidemic Gives Clues to Bird Flu Spread
4. MedHelp to Add Top Stanford Surgeons and Specialized Forums to Online Health Community
5. Online Celebrity Shoe Charity Auction for Womens Heart Health Opens Bidding
6. Syndicom to Launch Online Community for DePuy Spine
7. Elder Caregiving Site ShirleyBOARD.com Wins WebAward for Outstanding Online Community
8. Peer-Reviewed, Online Database Showcases Local, County and State Pandemic Planning
9. CIGNA Behavioral Health Offers Members Online Provider Profiles
10. Dynamic Energy Systems Goes Online and On-Demand
11. North Shore-LIJ Health System Begins Online Posting of Hospital Infection Rates, Other Performance Information
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/19/2014)... The elegant bamboo floorings from BambooIndustry.com are ... in an environmentally conscious way with the company’s floorings. ... have an aluminum oxide finish to help resist wear ... areas. , Recently, the company has released its new ... These fresh items are specially made for global customers. ...
(Date:8/19/2014)... As moms and dads prepare their children ... to the normal routine of dropping their little ones off ... MSc, RD encourages them to use the opportunity to ... , Yarker explains, “Kids have small tummies, short attention ... them junk food handouts, use snack time as another daily ...
(Date:8/19/2014)... 2014 BambooIndustry.com, a well-known bamboo product manufacturer ... deckings recently. The company is excited to reveal the ... special offer for all clients. Now, every customer can get ... will last until August 30. , The company’s deckings ... the world for supreme durability. They are perfect for a ...
(Date:8/19/2014)... Dentistry in Houston, Texas, is pleased to announce it is ... or with old fillings that need replacing, will benefit from ... restore teeth. , From now on any cavities will be ... completely amalgam free. Even though amalgam fillings have been deemed ... and children over the age of six, they do contain ...
(Date:8/19/2014)... Il (PRWEB) August 20, 2014 For ... allopathic medical world that chiropractic adjustments are dangerous and ... and this is why they do not recommend chiropractic ... more educated medical doctors do refer to chiropractors because ... However a statement regarding new research has popped up ...
Breaking Medicine News(10 mins):Health News:BambooIndustry.com Announces Up To 30% Discount On Its New Click Strand Woven Bamboo Floorings 2Health News:Child Nutritionist Kristen Yarker Wants Parents to Rethink Kids’ Snacks This Fall 2Health News:Child Nutritionist Kristen Yarker Wants Parents to Rethink Kids’ Snacks This Fall 3Health News:Promotional Bamboo Deckings from Well-known Online Supplier BambooIndustry.com 2Health News:Midtown Dentistry Announces It Is Now an Amalgam-Free Office 2Health News:Is It True That the Chiropractor Can Cause a Stroke? Dr. Harbison of AlignLife Wood River Speaks Up 2Health News:Is It True That the Chiropractor Can Cause a Stroke? Dr. Harbison of AlignLife Wood River Speaks Up 3Health News:Is It True That the Chiropractor Can Cause a Stroke? Dr. Harbison of AlignLife Wood River Speaks Up 4
... Shannon Malloy, critically injured in a car accident, skull separating ... call her recovery a miracle. ,A car ... her spine, although her skin, spinal cord and other internal ... internal decapitation, and it left her with no control over ...
... treatments. Since it is a very painful process, continuous attempts ... for the patient. ,Now researchers say that LHRH ... stop the production of a female hormone that encourages some ... action, often mimicking the action of a naturally occurring substance. ...
... and performance of other activities but as it turns out, ... ,This is the finding of a team of ... of Alberta. ,As a part study that was ... Canada, the researchers studied 24 patients, two-thirds of whom showed ...
... Moderate drinking may lower the risk of a type of ... ,The researchers at Brigham and Women's Hospital in ... of one alcoholic beverage a day were about 30 percent ... reduced risk they found in people who drank beer, wine ...
... towards making addition of folic acid to flour or bread mandatory ... disabilities. ,After lengthy public consultations the Food Standards ... its recommendations next month after it decides whether folic acid should ... ministers accept the FSA's proposals, it will be the first time ...
... a recent report, says that health specialists were able to ... the 2005 Bali bombings, thanks to improved procedures and services ... at the Royal Darwin Hospital who treated many of the ... health nurses. ,Says Anthony Guscott from Top End ...
Cached Medicine News:Health News:30-year-old Woman Survives 'internal Decapitation' 2Health News:A Fresh Alternative to Painful Chemotherapy Developed in UK 2Health News:Chronic Pain can Impair Memory and Concentration 2Health News:UK too Will Insist on Folic Acid in Bread 2Health News:UK too Will Insist on Folic Acid in Bread 3Health News:Bali Bombings Helped Improve Trauma Care 2Health News:Bali Bombings Helped Improve Trauma Care 3
(Date:8/19/2014)... , Aug. 19, 2014   Lincor Inc. ... patient experience technology to New Jersey ... five-year agreement, CarePoint Health will deploy Lincor,s PatientLINC ... Center, Christ Hospital and Hoboken University Medical Center. ... range of software solutions to help hospitals reach ...
(Date:8/19/2014)... Ala. , Aug. 19, 2014  The Alabama Supreme ... that patients can sue drug makers who mislead doctors into ... harmful side‑effects.  The case is Weeks v. Wyeth, and the ... makers in that same case last year. Heninger Garrison Davis ... represent the patient in the case, Danny Weeks . ...
(Date:8/19/2014)... Aug. 19, 2014 Talyst, a market leader ... at the 2014 NPPA Summer Conference in ... showcasing its 340B software products and services.   ... solutions, supplying over 400 customers with a variety of ... solutions including its latest solution, AutoSplit® Contract Pharmacy and ...
Breaking Medicine Technology:Lincor Announces Agreement With CarePoint Health For State-Of-The-Art Patient Engagement Technology 2Heninger Garrison Davis Clients To Get Their Day in Court Against Brand Drug Companies 2Heninger Garrison Davis Clients To Get Their Day in Court Against Brand Drug Companies 3Heninger Garrison Davis Clients To Get Their Day in Court Against Brand Drug Companies 4Talyst Exhibits at the NPPA Summer Conference 2
Streck-CD3500 Hemoglobin/Lyse is a lytic reagent for the quantitative determination of hemoglobin on the Abbott CELL-DYN® 3500 and 3700. The shelf life is two years from the date of manufacture....
Streck-Diluent III Plus is a balanced electrolyte solution manufactured specifically for use as a diluent for blood cell counting and sizing on the Abbott CELL-DYN® 3000, 3500 and 3700. The shelf...
Streck-Diluent IIIA is a balanced electrolyte solution manufactured specifically for use as a diluent for blood cell counting and sizing on the Abbott CELL-DYN® 1700. The shelf life is one year f...
Streck-Detergent IIIA is a balanced electrolyte solution for use as a rinsing and hemoglobin blanking diluent. It is manufactured specifically for use on the Abbott CELL-DYN® 1700 and 1800. The s...
Medicine Products: