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JCI online early table of contents: Feb. 14, 2011
Date:2/14/2011

EDITOR'S PICK: A hunk of a target for treating breast cancer

Among women with breast cancer, approximately 25% have a subtype that is characterized by high levels of expression of the protein HER2. HER2-positive breast cancer tends to be more aggressive than other breast cancer subtypes. Increased molecular understanding of why HER2-positive breast cancer is so aggressive could aid in the development of new therapeutics. By studying mouse models, a team of researchers, led by Lewis Chodosh, at the University of Pennsylvania School of Medicine, Philadelphia, has now identified a key role for the protein Hunk in the formation of tumors driven by overexpression of HER2. As the data also indicate that Hunk is required for HER2-induced tumor cells to maintain their cancerous characteristics, the team suggests that inhibiting Hunk might provide a new approach to treating HER2-positive breast cancer.

TITLE: Hunk is required for HER2/neu-induced mammary tumorigenesis

AUTHOR CONTACT:
Lewis A. Chodosh
University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.
Phone: 215.898.1321; Fax: 215.573.6725; E-mail: chodosh@mail.med.upenn.edu.

View this article at: http://www.jci.org/articles/view/42928?key=0163b99f546167e70104

EDITOR'S PICK: New combination therapy for solid tumors?

Most, if not all, solid tumors contain regions that are not well oxygenated. Tumor cells in these regions, which are known as hypoxic regions, are usually resistant to the death-inducing effects of chemotherapeutics. But now, Caroline Dive and colleagues, at Manchester University, United Kingdom, have identified a compound (ABT-737) that induces human cancer cells exposed to hypoxic conditions in vitro to undergo a form of cell death known as apoptosis. In additi
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Contact: Ushma Neill
press_releases@the-jci.org
734-546-5241
Journal of Clinical Investigation
Source:Eurekalert

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