Navigation Links
JCI online early table of contents: Feb. 14, 2011
Date:2/14/2011

EDITOR'S PICK: A hunk of a target for treating breast cancer

Among women with breast cancer, approximately 25% have a subtype that is characterized by high levels of expression of the protein HER2. HER2-positive breast cancer tends to be more aggressive than other breast cancer subtypes. Increased molecular understanding of why HER2-positive breast cancer is so aggressive could aid in the development of new therapeutics. By studying mouse models, a team of researchers, led by Lewis Chodosh, at the University of Pennsylvania School of Medicine, Philadelphia, has now identified a key role for the protein Hunk in the formation of tumors driven by overexpression of HER2. As the data also indicate that Hunk is required for HER2-induced tumor cells to maintain their cancerous characteristics, the team suggests that inhibiting Hunk might provide a new approach to treating HER2-positive breast cancer.

TITLE: Hunk is required for HER2/neu-induced mammary tumorigenesis

AUTHOR CONTACT:
Lewis A. Chodosh
University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.
Phone: 215.898.1321; Fax: 215.573.6725; E-mail: chodosh@mail.med.upenn.edu.

View this article at: http://www.jci.org/articles/view/42928?key=0163b99f546167e70104


EDITOR'S PICK: New combination therapy for solid tumors?

Most, if not all, solid tumors contain regions that are not well oxygenated. Tumor cells in these regions, which are known as hypoxic regions, are usually resistant to the death-inducing effects of chemotherapeutics. But now, Caroline Dive and colleagues, at Manchester University, United Kingdom, have identified a compound (ABT-737) that induces human cancer cells exposed to hypoxic conditions in vitro to undergo a form of cell death known as apoptosis. In additi
'/>"/>

Contact: Ushma Neill
press_releases@the-jci.org
734-546-5241
Journal of Clinical Investigation
Source:Eurekalert

Page: 1 2 3 4 5 6 7 8

Related medicine news :

1. TheReliefPlace.com Launches Online Store “The Relief Shop” - What Does this Medical Supply Store Carry and How Can They Help You?
2. Web Content Management Enables Government Transparency, Participation, and Collaboration Online
3. DavisPTnetwork Partners with the New York Physical Therapy Association to Provide Online Continuing Education
4. PERSONALABS Offers Discounted Healthy Heart Online Blood Tests in February
5. Pharmahelper Pleased To Recognize Online Pharmacy Practice Standards Announced By Google Adwords
6. Online Dating Reinvents Itself with the Recent Roll-Out of Teacherhookup.com, a Free Website that Focuses on a Person's Career in Education!
7. EdenHome.com Adds Aventura Organic Clothes to Site and Announces Largest Online Selection of Stylish Organic Clothes for Men, Women and Children
8. Fire Protection Online Resolves Safety Concerns with CO2 Fire Extinguishers
9. JCI online early table of contents: Feb. 15, 2010
10. Fitness Trend Towards Online Personal Training Gets Real-World Weight Loss Results on FitOrbit.com
11. New Online Store Makes Buying Cosmetics a Healthy Choice
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/21/2015)... Somerset, NJ & New York, NY (PRWEB) April ... the leading global provider of advanced delivery technologies ... health products, today announced the launch of ADVASEPT™ ... the safe and efficient delivery of injectable medications. ... syringe, combining a safe, convenient and functional container ...
(Date:4/21/2015)... Spokane, WA (PRWEB) April 21, 2015 ... Medical Practice Edition 2 for otolaryngologists, bringing the ... in the healthcare community. Otolaryngologists can now ... backed by a trusted source in the industry, ... successful integration with leading EHRs. , “Lyft is ...
(Date:4/21/2015)... April 21, 2015 QuickMedical, a ... and supplies, now represents Schiller America's ... ECGs, Stress Tests, and Vital Signs Monitors, among ... Switzerland, is a global leader in the development ... are developed in close cooperation with the world's ...
(Date:4/21/2015)... (PRWEB) April 21, 2015 On April ... Awards” EcoLuxe Lounge at the world famous Avalon Hollywood. ... sustainable product placement in TV and film, the EcoLuxe ... appearances at many awards ceremonies and festivals throughout the ... providers of eco-friendly and socially conscious products and services, ...
(Date:4/21/2015)... The 2015 Market Research Report on ... and in-depth study on the current state of ... a focus on the Chinese situation. , ... research are Cargill, Fbc Industries, Posy Pharmachem, Fuso, ... Lianyungang Mupro Fi, Yixing-Union, Debang Fine Chemical, Shuren ...
Breaking Medicine News(10 mins):Health News:Catalent Announces the Expansion of its Advanced, Aseptic, Glass-Free Injectable Platform with New ADVASEPT™ Lock Delivery Technology 2Health News:Lyft Expands Its Offerings to Include Dragon® Medical Practice Edition 2 for Otolaryngologists. 2Health News:QuickMedical Launches New Product Line: Schiller America 2Health News:QuickMedical Launches New Product Line: Schiller America 3Health News:Hollywood's Santana Dempsey and Choices Recovery South Bend Examine Victory over Personal Struggles 2Health News:Sodium Citrate Industry Global Key Manufacturers Analysis Report 2015-2020 2Health News:Sodium Citrate Industry Global Key Manufacturers Analysis Report 2015-2020 3
... S.D., Dec. 8 LodgeNet Interactive Corporation (Nasdaq: LNET ... hospitality and healthcare businesses, today announced that its Chairman and ... and Communications Conference on Wednesday, December 9, 2009, in New ... its success in proactively managing its business during the evolving ...
... , OAKLAND, Calif., Dec. ... a stress-free and harmonious year. To help people learn to live ... announced that it will dedicate 2010 to teaching people how to ... understanding and integrating one of the Principles, with a year-end intensive ...
... , SOUTH SAN FRANCISCO, Calif., Dec. 8 Anesiva, Inc. ... Anesiva approved the merger with Arcion Therapeutics, Inc. ("Arcion") during ... the merger, Anesiva stockholders also approved a one-for-forty reverse stock ... merger. , Closure of the merger remains contingent ...
... , LONDON, ... providers have gradually changed their perspective regarding the investment in ... solutions to save costs. Market players in the Healthcare IT ... partner with other companies to bring an innovative product to ...
... ... It offers new features for effectively working with Microsoft Office and high performance 64 ... (PRWEB) December ... and a powerful 64-bit capability. To date, InfoZoom has been known as one ...
... ... to announce the opening of a New Baltimore Office. REES believes ... permanent Baltimore presence will help serve our international clients more efficiently and ... Beverly Brandon. Beverly is a long-time resident of Baltimore, Maryland. ...
Cached Medicine News:Health News:LodgeNet Interactive to Participate in UBS' 37th Annual Global Media and Communications Conference 2Health News:LodgeNet Interactive to Participate in UBS' 37th Annual Global Media and Communications Conference 3Health News:LodgeNet Interactive to Participate in UBS' 37th Annual Global Media and Communications Conference 4Health News:LodgeNet Interactive to Participate in UBS' 37th Annual Global Media and Communications Conference 5Health News:The Breema Center Presents a Yearlong Campaign to Transform Stress into Harmony in 2010 and Beyond 2Health News:Anesiva Stockholders Approved Merger With Arcion Therapeutics but Merger Remains Contingent on Other Closing Conditions 2Health News:Anesiva Stockholders Approved Merger With Arcion Therapeutics but Merger Remains Contingent on Other Closing Conditions 3Health News:Frost & Sullivan to Hold Web Conference on Integrated Hospital Pharmacy Information Systems - How to Maneuver towards Growth Potential 2Health News:InfoZoom Launches V6.4 of its Industry Leading In-Memory Data Analysis Software 2Health News:InfoZoom Launches V6.4 of its Industry Leading In-Memory Data Analysis Software 3Health News:REES Announces New Baltimore Office 2
(Date:4/21/2015)... -- Inmark,s acquisition of Saf-T-Pak last week positioned Inmark ... Division 6.2.  For over 25 years, Saf-T-Pak has ... on IATA, ICAO, US DOT, Transport Canada, RID/ADR ... were particularly interested in Saf-T-Pak,s proprietary Learning Management ... programs," said David Oyler , Inmark President ...
(Date:4/21/2015)... April 21, 2015 Global cap ... World demand for caps and closures will exceed $55 billion ... exceed two trillion annually. Beverages will continue to account for ... and a number of smaller markets are expected to register ... Although the most developed markets -- the US, ...
(Date:4/21/2015)... 2015 The global dermatology diagnostic devices market ... from 2014 to 2019. North America ... shares in the global dermatology diagnostic devices market. The ... mainly attributed to a wide range of factors, such ... dermatologists, and technological advancements made in the field of ...
Breaking Medicine Technology:Inmark's Acquisition Of Saf-T-Pak Results In Expansion Of Its Dangerous Goods Training Portfolio 2World Caps & Closures Market 2World Caps & Closures Market 3Dermatology Diagnostic Devices Market by Product, by End-User - Global Forecast to 2019 2Dermatology Diagnostic Devices Market by Product, by End-User - Global Forecast to 2019 3
... and NEW YORK, July 14, 2011 ... company leveraging its proprietary drug-delivery platforms to develop treatments ... announced that its lead product for oral mucositis, ... benefit network.  Reimbursement coverage for MuGard is now available ...
... BLUE BELL, Pa., July 14, 2011 Inovio Pharmaceuticals, ... in the development of therapeutic and preventive vaccines against ... cell and antibody responses were generated in its Phase ... for the prevention of avian H5N1 influenza delivered using ...
Cached Medicine Technology:Access Pharmaceuticals MuGard Added to CVS Caremark's Pharmacy Benefit Network 2Access Pharmaceuticals MuGard Added to CVS Caremark's Pharmacy Benefit Network 3Inovio Pharmaceuticals Demonstrates Positive Immune Responses in Phase I Clinical Trial of SynCon™ H5N1 Influenza Vaccine and Launches Multi-Subtype Influenza Vaccine Phase I 2Inovio Pharmaceuticals Demonstrates Positive Immune Responses in Phase I Clinical Trial of SynCon™ H5N1 Influenza Vaccine and Launches Multi-Subtype Influenza Vaccine Phase I 3Inovio Pharmaceuticals Demonstrates Positive Immune Responses in Phase I Clinical Trial of SynCon™ H5N1 Influenza Vaccine and Launches Multi-Subtype Influenza Vaccine Phase I 4Inovio Pharmaceuticals Demonstrates Positive Immune Responses in Phase I Clinical Trial of SynCon™ H5N1 Influenza Vaccine and Launches Multi-Subtype Influenza Vaccine Phase I 5Inovio Pharmaceuticals Demonstrates Positive Immune Responses in Phase I Clinical Trial of SynCon™ H5N1 Influenza Vaccine and Launches Multi-Subtype Influenza Vaccine Phase I 6Inovio Pharmaceuticals Demonstrates Positive Immune Responses in Phase I Clinical Trial of SynCon™ H5N1 Influenza Vaccine and Launches Multi-Subtype Influenza Vaccine Phase I 7Inovio Pharmaceuticals Demonstrates Positive Immune Responses in Phase I Clinical Trial of SynCon™ H5N1 Influenza Vaccine and Launches Multi-Subtype Influenza Vaccine Phase I 8Inovio Pharmaceuticals Demonstrates Positive Immune Responses in Phase I Clinical Trial of SynCon™ H5N1 Influenza Vaccine and Launches Multi-Subtype Influenza Vaccine Phase I 9
Inquire...
The autoclavable, aluminum needle box is designed to store loaded needles and help protect personnel from exposure. Each shield consists of an aluminum box with faceplate to match the grid pattern th...
... Brachytherapy loaders allow for efficient, easy ... Connectors to your customized plans at ... Bard loaders is the flexibility to ... in the QuickLoad™ Loader allows for ...
... designed to help you achieve one important ... procedure. All needles are engineered for exceptional ... for smooth entry and exit. A broad ... an ideal match with procedural needs and ...
Medicine Products: