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JCI online early table of contents: Feb. 1, 2012
Date:2/1/2012

View this article at: http://www.jci.org/articles/view/58530?key=b593e40b17636db485f1


ONCOLOGY: Taking on features of cancer cells

The protein p27Kip1 has a role in suppressing tumor development and progression. It does so by inhibiting the activity of protein complexes that promote cell proliferation (cyclincyclin-dependent kinase complexes). In contrast, mutant forms of p27Kip1 that cannot inhibit cyclincyclin-dependent kinase complexes promote tumor development in mice. Now, a team of researchers led by Arnaud Besson, at INSERM UMR1037, France, has identified a mechanism by which mutant forms of p27Kip1 that cannot inhibit cyclincyclin-dependent kinase complexes promote cells to take on features of cancer cells. Future studies will determine whether normal p27Kip1 protein can regulate the same mechanism if mislocalized, as it often is in human tumors.

TITLE: p27Kip1 controls cytokinesis via the regulation of citron kinase activation

AUTHOR CONTACT:
Arnaud Besson
INSERM UMR1037, Cancer Research Center of Toulouse, Toulouse, France.
Phone: 33.561556435; Fax: 33.561558109; E-mail: arnaud.besson@inserm.fr.

View this article at: http://www.jci.org/articles/view/60376?key=2721832273bd35b1e9f0


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Contact: Karen Honey
press_releases@the-jci.org
734-546-5242
Journal of Clinical Investigation
Source:Eurekalert

Page: 1 2 3 4 5

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