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JCI online early table of contents: Feb. 1, 2012
Date:2/1/2012

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View this article at: http://www.jci.org/articles/view/45817?key=3f332821bf27bc9a78d3


VIROLOGY: Finally, experimental transformation of a primary cell into a tumor cell by the cancer-causing virus KSHV

Kaposi sarcoma herpesvirus (KSHV) is the causative agent of several cancers that arise most commonly in individuals with HIV/AIDS. Developing therapeutic approaches to treat individuals with these cancers is hampered by a lack of understanding of the mechanisms by which KSHV transforms normal cells into cancerous cells. This is poorly understood in part because researchers have been unable to experimentally infect a primary cell with KSHV and turn it into a cancer cell. However, Shou-Jiang Gao and colleagues, at the University of Texas Health Science Center at San Antonio, San Antonio, have now done just that.

Gao and colleagues found that KSHV efficiently infects primary rat embryonic metanephric mesenchymal precursor cells and transforms them into cells that form tumors when injected into mice. They hope to use this model to study the molecular mechanisms by which KSHV transforms normal cells into cancerous cells, although they caution that additional analysis would be required to determine whether mechanisms uncovered using transformed rat cells are relevant to human cancers caused by KSHV.

TITLE: Direct and efficient cellular transformation of primary rat mesenchymal precursor cells by KSHV

AUTHOR CONTACT:
Shou-Jiang Gao
University of Southern California, Keck School of Medicine, Los Angeles, California, USA.
Phone: 323.442.8028; Fax: 323.442.1721; E-mail: shoujiag@usc.edu.


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Contact: Karen Honey
press_releases@the-jci.org
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Journal of Clinical Investigation
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