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JCI online early table of contents: Feb. 1, 2012
Date:2/1/2012

ll liposarcoma

AUTHOR CONTACT:
Igor Matushansky
Columbia University, New York, New York, USA.
Phone: 212.851.4556; Fax: 212.851.4784; E-mail: im17@columbia.edu.

View this article at: http://www.jci.org/articles/view/60015?key=ace2cdfd6a47aee95dac


TUMOR IMMUNOLOGY: Access denied: dense matrix blocks immune cell path to cancer cells

An individual's immune system does respond to a tumor. However, in individuals diagnosed with cancer, the antitumor response was obviously inadequate to clear the tumor. It is hoped that understanding how tumors escape the antitumor immune response will identify candidate therapeutic approaches, with the rationale being that if the escape mechanism can be blunted then an individual's immune system will be able to destroy the tumor. In this context, a team of researchers led by Emmanuel Donnadieu, at Institut Cochin, France, has determined that in human lung tumors, immune cells known as T cells are rarely found in the clusters of cancer cells. Rather, they accumulate in the stromal region of the tumors (that is, the tissue that surrounds and supports the cancer cells). Moreover, Donnadieu and colleagues found that the T cells could not enter the cancer cell regions because a dense matrix that the T cells could not penetrate surrounded these regions. Treating human lung tumor slices with matrix-degrading compounds increased the ability of T cells to enter the cancer cell clusters. Donnadieu and colleagues hope that future studies will increase understanding of the mechanisms by which the dense matrix is generated and thereby identify potential new therapeutic approaches.

TITLE: Matrix architecture defines the preferential localization and migration of T cells into the stroma of human lung tumors

AUTHOR CONTACT:
Emmanuel Donnadieu '/>"/>

Contact: Karen Honey
press_releases@the-jci.org
734-546-5242
Journal of Clinical Investigation
Source:Eurekalert

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