Navigation Links
JCI online early table of contents: Feb. 1, 2012
Date:2/1/2012

EDITOR'S PICK: A thought-provoking new therapeutic target for brain cancer?

Glioblastoma multiforme (GBM) is the most common of all malignant brain tumors that originate in the brain. Patients with GBM have a poor prognosis because it is a highly aggressive form of cancer that is commonly resistant to current therapies. New therapeutic approaches are therefore much needed. Joanna Phillips, Zena Werb, and colleagues, at the University of California, San Francisco, have now identified a potential new therapeutic target for the treatment of GBM.

A substantial proportion of GBMs show evidence of abnormal activation of signaling pathways triggered by a cell surface protein known as PDGFR-alpha, and this is thought to drive the tumor. PDGFR-alpha triggers activation of signaling pathways when it binds the growth factor PDGF. Phillips, Werb, and colleagues found that the protein SULF2, which is known to regulate the availability of growth factors such as PDGF, was expressed in primary human GBM tumors and cell lines. Moreover, GBMs characterized by abnormal activation of signaling pathways downstream of PDGFR-alpha showed the strongest SULF2 expression. Importantly, knocking down expression of SULF2 in human GBM cell lines decreased the growth of these cells upon transplantation into mice. Phillips, Werb, and colleagues therefore suggest that SULF2 is a candidate therapeutic target for the treatment of GBM and that assessing its levels could identify tumors dependent on growth factors such as PDGF. The latter is important as PDGFR-alpha and other molecules to which growth factors bind are themselves good therapeutic targets.

TITLE: Heparan sulfate sulfatase SULF2 regulates PDGFR-alpha signaling and growth in human and mouse malignant glioma

AUTHOR CONTACT:
Joanna J. Phillips
University of California, San Francisco, San Francisco, California, USA.
Phone: 415.514.4929; Fax: 415.514.9792; E-mail:

Contact: Karen Honey
press_releases@the-jci.org
734-546-5242
Journal of Clinical Investigation
Source:Eurekalert

Page: 1 2 3 4 5

Related medicine news :

1. JCI online early table of contents: Jan. 17, 2012
2. JCI online early table of contents: Jan. 9, 2012
3. Simple online tool to aid GPs in early ovarian cancer diagnosis
4. JCI online early table of contents: Dec. 27, 2011
5. JCI online early table of contents: Dec. 19, 2011
6. Online guide helps health organizations adopt electronic health records
7. JCI online early table of contents: Dec. 12, 2011
8. JCI online early table of contents: Nov. 21, 2011
9. Bullying Moves From Online to Text-Messaging: Study
10. JCI online early table of contents: Nov. 14, 2011
11. JCI online early table of contents: Nov. 7, 2011
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/1/2014)... sound may be bad for your waistline. TV viewers ... an excerpt from a Hollywood action film than those ... blamed for helping Americans to gain weight because it ... has been on the medium and not the message. ... people to eat more, including reading, listening to the ...
(Date:9/1/2014)... Sept. 1, 2014 (HealthDay News) -- You may be able ... unhealthy ones, new research suggests. The study included eight ... designed weight-loss program meant to change how people react to ... of five overweight and obese people who weren,t in the ... start of the study and again six months later. The ...
(Date:9/1/2014)... An operating theatre or operating room ... surgical operations. An operating room comprises a myriad of ... room lights, imaging displays as well as integration systems ... Market Research, a U.S.-based market research firm, the operating ... billion by 2019. , According to this report, ...
(Date:9/1/2014)... HealthDay Reporter FRIDAY, Aug. 29, ... to two American aid workers successfully cured a group of ... report. The drug, ZMapp, prompted recovery in all 18 ... medication until five days after infection. ZMapp even cured ... even hours away from death, said study senior author Gary ...
(Date:9/1/2014)... D.C. (PRWEB) September 01, 2014 The ... pleased to announce that Dawn Bazarko, DNP, MPH, RN, ... Fellows of the American Academy of Nursing. They will ... MBA, RN-BC, CCM, FACHE, whose induction we reported last ... October 18, 2014, during the 2014 American Academy of ...
Breaking Medicine News(10 mins):Health News:Research letter: Viewers ate more while watching Hollywood action flick on TV 2Health News:Train Your Brain to Choose Fruit Salad Over French Fries 2Health News:Operating Room Equipment Market Study 2019 by Transparency Market Research 2Health News:Operating Room Equipment Market Study 2019 by Transparency Market Research 3Health News:Monkey Trial Supports Ebola Drug That May Have Helped 2 Stricken Americans 2Health News:Monkey Trial Supports Ebola Drug That May Have Helped 2 Stricken Americans 3Health News:Two Additional NAHN Members to be Inducted as Fellows of the American Academy of Nursing 2Health News:Two Additional NAHN Members to be Inducted as Fellows of the American Academy of Nursing 3Health News:Two Additional NAHN Members to be Inducted as Fellows of the American Academy of Nursing 4
... News) -- Sleep problems and fatigue are common among ... memory, researchers say. The finding was based on ... the Childhood Cancer Survivor Study, an investigation of long-term ... were treated between 1970 and 1986. More than ...
... pregnancy is associated with an increased risk of miscarriage, premature ... about how much alcohol, if any, it is safe for ... Central,s open access journal BMC Pregnancy and Childbirth ... early pregnancy and showed the effect this had on their ...
... sinus tissue removed during surgery at University of Wisconsin Hospital ... to grow a recently discovered species of human rhinovirus (HRV), ... , The researchers found that the virus, which is ... children, has reproductive properties that differ from those of other ...
... Warning labels on junk food would be more effective than ... purchases, a new University of Alberta study has found. A ... that while price alone wouldn,t deter people from reaching for ... heed a label that warned of high fat content and ...
... service was launched today to help primary care providers ... Physician Clinical Support System for Primary Care (PCSS-P), offers ... into regular patient care. PCSS-P is a project ... of the National Institutes of Health, and the American ...
... 8 (HealthDay News) -- Unemployment can be deadly, especially for ... analyzed 40 years of data from 20 million people in ... risk of premature death by 63 percent. The quality of ... risk, the study authors noted. They also found ...
Cached Medicine News:Health News:Sleep Problems May Linger After Childhood Cancer 2Health News:Drinking during pregnancy increases risk of premature birth 2Health News:Insights gained from growing cold-causing virus on sinus tissue 2Health News:Warning labels better than a fat tax, University of Alberta study shows 2Health News:New warm line helps clinicians tackle patients' substance abuse 2Health News:Unemployment Plays Role in Early Deaths, Research Shows 2
(Date:8/29/2014)... , Aug. 29, 2014   Vittamed Corporation , a ... announced today that T. (Teo) Forcht Dagi , ... company,s Board of Directors. " Teo Forcht ... in neurosurgery, medical innovation and venture capital," said Remis ... delighted to add his clinical, strategic, and entrepreneurial expertise to ...
(Date:8/29/2014)... , Aug. 29, 2014 Research and ... "Global Multiple Sclerosis Drugs Market 2014-2018" report to ... chronic, inflammatory medical condition that results in demyelination, axonal ... of an abnormal response by the immune system, which ... is a potentially debilitating disease in which the damage ...
(Date:8/29/2014)... August 29, 2014 Pixcelldata, the ... software has announced a major new deal with Dutch ... renowned pathology expert, Dr. Marius Nap . ... 26th European Congress of Pathology which is taking placing ... Arena, London where Pixcelldata will ...
Breaking Medicine Technology:Vittamed Adds Prominent Neurosurgeon and Venture Capitalist T. Forcht Dagi to Board of Directors 2Global Multiple Sclerosis Drugs Market 2014-2018: Key Vendors are Bayer, Biogen Idec, Merck Serono, Novartis and Teva Pharmaceutical 2Global Multiple Sclerosis Drugs Market 2014-2018: Key Vendors are Bayer, Biogen Idec, Merck Serono, Novartis and Teva Pharmaceutical 3Pixcelldata Announces New Deal with Dutch Tele-Pathology Specialists eX-Path Ahead of ECP 2014 2
... April 14, 2011 Reportlinker.com announces that a new ... Neuropathy Therapy Area Pipeline Report ... Area Pipeline Report contains detailed information on the neuropathy ... status of neuropathy drugs by company and by stage ...
... 14, 2011 Reportlinker.com announces that a new ... Juvenile Rheumatoid Arthritis (JRA) Therapeutics ... http://www.reportlinker.com/p0479828/Juvenile-Rheumatoid-Arthritis-JRA-Therapeutics---Pipeline-Assessment-and-Market-Forecasts-to-2017.html ... and Market Forecasts to 2017 ...
Cached Medicine Technology:Reportlinker Adds Neuropathy Therapy Area Pipeline Report 2Reportlinker Adds Neuropathy Therapy Area Pipeline Report 3Reportlinker Adds Juvenile Rheumatoid Arthritis (JRA) Therapeutics - Pipeline Assessment and Market Forecasts to 2017 2Reportlinker Adds Juvenile Rheumatoid Arthritis (JRA) Therapeutics - Pipeline Assessment and Market Forecasts to 2017 3Reportlinker Adds Juvenile Rheumatoid Arthritis (JRA) Therapeutics - Pipeline Assessment and Market Forecasts to 2017 4Reportlinker Adds Juvenile Rheumatoid Arthritis (JRA) Therapeutics - Pipeline Assessment and Market Forecasts to 2017 5Reportlinker Adds Juvenile Rheumatoid Arthritis (JRA) Therapeutics - Pipeline Assessment and Market Forecasts to 2017 6Reportlinker Adds Juvenile Rheumatoid Arthritis (JRA) Therapeutics - Pipeline Assessment and Market Forecasts to 2017 7Reportlinker Adds Juvenile Rheumatoid Arthritis (JRA) Therapeutics - Pipeline Assessment and Market Forecasts to 2017 8
... Injection molded chambers are seamless eliminating the possibility ... The Primo tanks have temperature resistant gel trays ... pour you gels. For added user friendliness, the ... UV fluorescent rule. The Primo Gel Systems ...
... up and safe to use, the Gel XL ... and running agarose gels. The unit is compact, ... power supply eliminates a tangled mess of leads ... Designed for safety and convenience, the power supply ...
... 33 Mini Submarine Unit for nucleic acid analysis in ... for very fast separations of DNA restriction fragments in ... heat-sink. Fill the base with coolant and seal. Precool ... the unit in a freezer or by immersing it ...
... 2000 apparatus and ready-to-use gels are the ... of nucleic acids by submerged gel electrophoresis. ... system, offering full compatibility and optimal performance, ... SEA 2000 and a unique staining tray, ...
Medicine Products: