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JCI online early table of contents: Dec. 6, 2010
Date:12/6/2010

CT:
Michael P. Schn
Georg August University, Gttingen, Germany.
Phone: 49.551.39.6401; Fax: 49.551.39.6841;
E-mail: michael.schoen@med.uni-goettingen.de.

View this article at: http://www.jci.org/articles/view/41295?key=9fdf418e69584eec49cc


VIROLOGY: How hepatitis C virus uses the cells it infects to its own advantage

The current therapy to treat individuals infected with hepatitis C virus (HCV) works in only about half of those treated. Therefore, many individuals remain chronically infected with HCV, something that often leads to liver failure and liver cancer. Research using human liver cell lines, performed by Po-Yuan Ke and Steve Chen, at Academia Sinica, Taiwan, has identified new ways in which HCV coopts normal cellular processes in the cells that it infects to enhance its reproduction and to evade certain aspects of the antiviral immune response. These data not only provide new insight into the ways in which interactions between HCV and the cells it infects can benefit the virus, but also provide potential new avenues of research for the development of novel therapeutic approaches to clearing HCV infection.

TITLE: Activation of the unfolded protein response and autophagy after hepatitis C virus infection suppresses innate antiviral immunity in vitro

AUTHOR CONTACT:
Steve S.-L. Chen
Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
Phone: 886.2.2652.3933; Fax: 886.2.2652.3073; E-mail: schen@ibms.sinica.edu.tw.

View this article at: http://www.jci.org/articles/view/41474?key=b8efc145f04abae00e4e


PULMONARY: Pinpointing a role for the molecule TGF-beta in lung scarr
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Contact: Karen Honey
press_releases@the-jci.org
734-546-5242
Journal of Clinical Investigation
Source:Eurekalert

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