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JCI online early table of contents: Dec. 6, 2010
Date:12/6/2010

zation. Importantly, molecules known as antibodies that target these bacterial products inhibited bacterial spread in the mouse model, leading the authors to suggest that interfering with biofilm detachment mechanisms might provide a new approach to preventing biofilm-associated infections.

TITLE: Staphylococcus epidermidis surfactant peptides promote biofilm maturation and dissemination of biofilm-associated infection in mice

AUTHOR CONTACT:
Michael Otto
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Phone: 301.443.5209; Fax: 301.480.3633; E-mail: motto@niaid.nih.gov.

View this article at: http://www.jci.org/articles/view/42520?key=109e2fdc23f5ff35648c


DERMATOLOGY: Targeting blood vessel growth to treat psoriasis

Psoriasis is a common skin disorder that arises when immune cells become overactive and generate unneeded inflammatory responses in the skin. Dysregulated growth of new blood vessels from pre-existing vessels (a process known as angiogenesis) is one hallmark of psoriasis, which is also characterized by thick silvery scales on affected areas of skin and itchy, dry, red patches. A team of researchers, led by Michael Schn, at Georg August University, Germany, has now found that reducing angiogenesis in xenotransplantation models of psoriasis and in mice with a disease that resembles psoriasis alleviates disease. They therefore suggest that their non-viral gene therapy approach to reducing angiogenesis might provide a new approach to treating psoriasis and, perhaps, other inflammatory skin disorders characterized by dysregulated angiogenesis.

TITLE: Halting angiogenesis by non-viral somatic gene therapy alleviates psoriasis and murine psoriasiform skin lesions

AUTHOR CONTA
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Contact: Karen Honey
press_releases@the-jci.org
734-546-5242
Journal of Clinical Investigation
Source:Eurekalert

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