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JCI online early table of contents: Dec. 6, 2010
Date:12/6/2010

f the uterus and before the placenta is established, a structure known as the decidua forms and is key to supporting embryonic development. Defective formation of an effective decidua is thought to be a cause of female infertility. A team of researchers, led by Toru Miyazaki, at the University of Tokyo, Japan, has now determined that the protein DEDD is required for the formation of a functional decidua in mice. The authors therefore suggest that it would be interesting to investigate whether DEDD dysfunction is the cause of infertility in some women.

TITLE: Death effector domaincontaining protein (DEDD) is required for uterine decidualization during early pregnancy in mice

AUTHOR CONTACT:
Toru Miyazaki
Center for Disease Biology and Integrative Medicine, The University of Tokyo, Tokyo, Japan.
Phone: 81.3.5841.1435; Fax: 81.3.5841.1438; E-mail: tm@m.u-tokyo.ac.jp.

View this article at: http://www.jci.org/articles/view/44723?key=1ec7d446ccdf85707aaa


EDITOR'S PICK: How bacteria get from catheter to patient

Patients in hospitals and healthcare facilities can develop infections as a result of contamination of indwelling medical devices such as catheters with bacteria that are normal inhabitants of the skin of the patient or health care personnel. The bacterium Staphylococcus epidermidis is a major cause of such infections. This is in part because of its ability to form biofilms surface-attached agglomerations of microorganisms that are extremely difficult to eradicate on indwelling devices. Michael Otto and colleagues, at the National Institutes of Health, Bethesda, have now identified the bacterial products that enable Staphylococcus epidermidis biofilms to detach from the surface to which they are adhered and cause infection in a mouse model of catheteri
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Contact: Karen Honey
press_releases@the-jci.org
734-546-5242
Journal of Clinical Investigation
Source:Eurekalert

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